Protein Alignment GluRIID and Grik4

DIOPT Version :10

• Sequence 1: NP_651982.1
• Gene: GluRIID / 44483
• FlyBaseID: FBgn0028422
• Length: 902
• Species: Drosophila melanogaster
• Sequence 2: NP_780690.2
• Gene: Grik4 / 110637
• MGIID: 95817
• Length: 956
• Species: Mus musculus
• Alignment Length: 874
• Identity: 291/874 - (33%)
• Similarity: 464/874 - (53%)
• Gaps: 63/874 - (7%)

  Fly    28 ASSGQSIRLGLITDDAT-----DRIRQTF-EHAISVVNNELGVPLVGETE--QVAYGNSVQAFAQ 84
            |.|..|:|:..|.||..     :|:..|. ::.|:.....||...| |.:  ::...:..:....
Mouse    19 ACSPHSLRIAAILDDPMECSRGERLSITLAKNRINRAPERLGKAKV-EVDIFELLRDSEYETAET 82

  Fly    85 LCRLMQSGVGAVFGPAARHTASHLL-NACDSKDIPFIYPHLSWGSNPDGF-----------NLHP 137
            :|:::..||.||.||::...:|.:: |.|..|::    ||....  |:.|           ||||
Mouse    83 MCQILPKGVVAVLGPSSSPASSSIISNICGEKEV----PHFKVA--PEEFVRFQLQRFTTLNLHP 141

  Fly   138 SPEDIANALYDIVNQFEWSRFIFCYESAEYLKILDHLMTRYGIKGPVIKVMRYDLNLNGNYKSVL 202
            |..||:.|:..|:|.|..:........||.|..|:.|:.::.|....:.|...|...:..  .:|
Mouse   142 SNTDISVAVAGILNFFNCTTACLICAKAECLLNLEKLLRQFLISKDTLSVRMLDDTRDPT--PLL 204

  Fly   203 RRIRKSEDSRIVVVGSTTGVAELLRQAQQVGIMNEDYTYIIGNLNLHTFDLEEYKYSEANITGIR 267
            :.||..:.:.|::..:.:....:|.:|.::|:::..||||..||......::.......||.|..
Mouse   205 KEIRDDKTATIIIHANASMSHTILLKAAELGMVSAYYTYIFTNLEFSLQRMDSLVDDRVNILGFS 269

  Fly   268 MFSPDQEEVRDLMEKLHQELGES---EPVNSGSTFITMEMALTYDAVRVIAETTKHLPYQPQM-- 327
            :|:......::..:.|:|...|:   .|.    |...:..||.:|||..:....:.|....::
Mouse   270 IFNQSHAFFQEFSQSLNQSWQENCDHVPF----TGPALSSALLFDAVYAVVTAVQELNRSQEIGV 330

  Fly   328 --LNCSERHDNVQPDGSTFRNYMRSLEIKEKTITGRIYFEG-NVRKGFTFDVIELQTSGLVKVGT 389
              |:|...  .:...|::..||:|.:|:  :.:||.|.|.. ..|..:...:::...:|..::|.
Mouse   331 KPLSCGSA--QIWQHGTSLMNYLRMVEL--EGLTGHIEFNSKGQRSNYALKILQFTRNGFQQIGQ 391

  Fly   390 WEEGKDFEFQRPPQAVNFNDIDDGSLVNKTFIVLISVATKPYASLVESIDTLIGNNQFQGYGVDL 454
            |...:.........|.|.:|    ||.|.| :|:.::...||..|..:...:.||::::|:.||:
Mouse   392 WHVAEGLSMDSRLYASNISD----SLFNTT-LVVTTILENPYLMLKGNHQEMEGNDRYEGFCVDM 451

  Fly   455 IKELADKLGFNFTFRDGGNDYGSFNKTTNSTSGMLKEIVEGRADLAITDLTITSEREEVIDFSIP 519
            :||||:.|.||:..|..|:......:...:.:||:.|::..:||||:..||||:|||:|||||.|
Mouse   452 LKELAEILRFNYKIRLVGDGVYGVPEANGTWTGMVGELIARKADLAVAGLTITAEREKVIDFSKP 516

  Fly   520 FMNLGIAILYVKPQKAPPALFSFMDPFSSEVWLYLGIAYLGVSLCFFIIGRLSPIEWDNPYPCIE 584
            ||.|||:|||.......|..|||:||||..|||::.:|||.||...|::.||:|.||.:|:||.:
Mouse   517 FMTLGISILYRVHMGRRPGYFSFLDPFSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYSPHPCAQ 581

  Fly   585 -EPEELENQFTINNSLWFTTGALLQQGSEIAPKALSTRTISAIWWFFTLIMVSSYTANLAAFLTI 648
             ....|.||:::.|||||..|..:||||.|||:|||||.:|.:||.||||::||||||||||||:
Mouse   582 GRCNLLVNQYSLGNSLWFPVGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTV 646

  Fly   649 ENPTSPINSVKDLADNKDDVQYGAKRTGSTRNFFSTSEEPIYIKMNEYL-NAHPEMLMENNQQGV 712
            :....||.||.|||| :..::||....||:..||..|....|.:|..|: :..|.:.:::.::|:
Mouse   647 QRMEVPIESVDDLAD-QTAIEYGTIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVFVKSTEEGI 710

  Fly   713 DKVKSGTKYAFLMESTSIEFNTVRECNLTKVGDPLDEKGYGIAMVKNWPYRDKFNKALLELQEQG 777
            .:|.: :.||||:|||..|:...|.||||::|..||.|||||.|.....:||:|:.|:|:|||..
Mouse   711 ARVLN-SNYAFLLESTMNEYYRQRNCNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAILQLQENN 774

  Fly   778 VLARLKNKWWNEVGAGVCSAKSDDDGPSELGVDNLSGIYVVLVIGSIISIIISIL--CWCYFVYK 840
            .|..||.|||.   .|.| .|.:|.....||::|:.||:|||:.|.|::|.:::|  .|   ..:
Mouse   775 RLEILKRKWWE---GGKC-PKEEDHRAKGLGMENIGGIFVVLICGLIVAIFMAMLEFLW---TLR 832

  Fly   841 KAKNYEVPFCDALAEEFRIVIRFSENERP 869
            .::..||..|..:..|.|.:|...:|..|
Mouse   833 HSEASEVSVCQEMVTELRNIILCQDNIHP 861

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIID	NP_651982.1	PBP1_iGluR_Kainate	35..400	CDD:380605	88/392 (22%)
		PBP2_iGluR_Kainate	417..788	CDD:270432	169/372 (45%)
		Lig_chan	547..819	CDD:459656	125/273 (46%)
Grik4	NP_780690.2	Periplasmic_Binding_Protein_type1	24..402	CDD:471960	89/394 (23%)
		PBP2_iGluR_kainate_KA1	415..785	CDD:270442	169/372 (45%)
		QRL_CxxC_CxxC	863..927	CDD:469521
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	931..956