DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GluRIID and LOC110438919

DIOPT Version :9

Sequence 1:	NP_651982.1	Gene:	GluRIID / 44483	FlyBaseID:	FBgn0028422	Length:	902	Species:	Drosophila melanogaster
Sequence 2:	XP_021328141.1	Gene:	LOC110438919 / 110438919	-ID:	-	Length:	1417	Species:	Danio rerio

Alignment Length:	798	Identity:	192/798 - (24%)
Similarity:	343/798 - (42%)	Gaps:	167/798 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 FNLHPSPEDIANALYDIVNQFEWSRFIFCYESAEYLKILDHL-MTRYGIKGPVI-----KVMRYD 191
            |...||.|..|:.:.:|:.:::|  :||...:..|....|.: ..|..|:...:     :|:..|
Zfish     3 FQFGPSIEQQASVMLNIMEEYDW--YIFSIVTTYYPGYQDFVTKIRSTIENSFVGWELEEVLLLD 65

  Fly   192 LNL-NGNYKSVLRRIRKSEDSRIVVVGSTTGVAELLRQ-AQQVGIMNEDYTYIIGNLNLHTFDLE 254
            ::: :|:.|  ::.:.|...|.::::.||...|.::.| |..||:....||:|:.:|.....|..
Zfish    66 MSVDDGDAK--IQNLLKKLQSPVILLYSTKEEANIIFQVAHSVGLTGYGYTWIVPSLVAGDADHI 128

  Fly   255 EYKYSEANITGIRMFSPDQEEVRDLMEKLHQELGESEPVNSGSTFITMEMALTYDAVRVIAETTK 319
            ..::.    ||:...|.|:           .:.|....|..|.            ||...|.:|.
Zfish   129 PAEFP----TGMISVSYDE-----------WDYGLEARVRDGV------------AVIATATSTM 166

  Fly   320 HLPYQPQMLNCSERHDNVQPDGSTFRNYMRSLEIKEKTITG----------RIYFEGNVRKGFTF 374
            .:...|..|..||.|.  .||             |:..:||          .:.|||. ...|:.
Zfish   167 MMDRGPHTLLKSECHG--APD-------------KKSPMTGNNNEVLRYLMNVTFEGR-NLSFSE 215

  Fly   375 DVIELQTSGLV----------KVGTWEEGK---------DFEFQRPPQAVNFNDIDDGSLVNKTF 420
            |..::....::          :||.||.|.         .||....|:|..    ||       .
Zfish   216 DGYQMHPKLVIILLDKERQWDRVGKWENGSLSMKYHVWPRFELYSGPEARE----DD-------H 269

  Fly   421 IVLISVATKPYASLVESIDTLIGN---------------NQFQ-----------GYGVDLIKELA 459
            :.::::...|:. :||.:|.|.|.               ||.|           |:.:|::|::|
Zfish   270 LSIVTLEEAPFV-IVEDVDPLSGTCMRNTVPCRKQLKALNQTQDSAVYIKRCCKGFCIDILKKIA 333

  Fly   460 DKLGFNFTFRDGGNDYGSFNKTTNST-SGMLKEIVEGRADLAITDLTITSEREEVIDFSIPFMNL 523
            ..:.|.:......|  |...|..|.| :||:.|:|...|.:|:..|||..||.||||||:||:..
Zfish   334 KNVKFTYDLYLVTN--GKHGKKINGTWNGMVGEVVLKNAHMAVGSLTINEERSEVIDFSVPFIET 396

  Fly   524 GIAILYVKPQKAPPALFSFMDPFSSEVWLYLGIAYLGVS-LCFFIIGRLSPIEWDNPYPCIEEPE 587
            ||::: |.......:..:|::|||::||:.:.:..|.|| :..||....||:.::.   |:.:..
Zfish   397 GISVM-VSRSNGTVSPSAFLEPFSADVWIMMFVMLLLVSAIAVFIFEYFSPVGYNR---CLADGR 457

  Fly   588 ELEN-QFTINNSLWFTTGALLQQGSEIA-PKALSTRTISAIWWFFTLIMVSSYTANLAAFLTIEN 650
            |... .|||..::|...|.:......:. |:..:::.:.::|.||.:|.::|||||||||:..|.
Zfish   458 EAGGPSFTIGKAIWLLWGLVFNNSVPVQNPRGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEE 522

  Fly   651 PTSPINSVKDLA-DNKDD----VQYGAKRTGST-RNFFSTSEEPIYIKMNEYLNAHPEML---ME 706
            ....::.:.|.. .|.:|    .::|....||| ||.           .|.|.:.|..|:   ..
Zfish   523 YVDQVSGLSDKKFQNPNDFSPPFRFGTVPNGSTERNI-----------RNNYRDMHSYMVKFHQR 576

  Fly   707 NNQQGVDKVKSGTKYAFLMESTSIEFNTVRE--CNLTKVGD--PLDEKGYGIAMVKNWPYRDKFN 767
            |..:.::.:|:|...||:.::..:.:...|:  |.|..:|.  .....|||||:.|:..::.:.:
Zfish   577 NVVEALESLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQKDSGWKRQVD 641

  Fly   768 KALLELQEQGVLARLKNKWWNEVGAGVCSAKSDDDGPSELGVDNLSGIYVVLVIGSIISIIISIL 832
            .|:|:|...|.:..|:..|.    .|:|..:.::...|:|.|||::|::.:|.....:|:|.
Zfish   642 LAILQLFGDGEMEELEALWL----TGICHHEKNEVMSSQLDVDNMAGVFYMLGAAMALSLIT--- 699

  Fly   833 CWCYFVYKKAKNYEVPFC 850
                |:.:....:.:.||
Zfish   700 ----FIAEHVFYWHMRFC 713

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIID	NP_651982.1	PBP1_iGluR_Kainate	35..397	CDD:107377	62/300 (21%)
		ANF_receptor	46..380	CDD:279440	57/264 (22%)
		PBP2_iGluR_Kainate	417..788	CDD:270432	110/413 (27%)
		Lig_chan	549..819	CDD:278489	73/285 (26%)
LOC110438919	XP_021328141.1	PBP1_iGluR_NMDA_NR2	<1..255	CDD:107373	62/298 (21%)
		PBP2_iGluR_NMDA_Nr2	267..667	CDD:270436	114/428 (27%)
		DUF4013	<389..478	CDD:315788	27/92 (29%)
		NMDAR2_C	704..1417	CDD:313729	2/10 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591269
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740