DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIID and grik3

DIOPT Version :9

Sequence 1:	NP_651982.1	Gene:	GluRIID / 44483	FlyBaseID:	FBgn0028422	Length:	902	Species:	Drosophila melanogaster
Sequence 2:	XP_031752773.1	Gene:	grik3 / 100498426	XenbaseID:	XB-GENE-6050069	Length:	919	Species:	Xenopus tropicalis

Alignment Length:	919	Identity:	327/919 - (35%)
Similarity:	514/919 - (55%)	Gaps:	98/919 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 IRLGLI-------TDDATDRIRQTFEHAISVVN-NELGVP---LVGETEQVAYGNSVQAFAQLCR 87
            ||:|.|       |........|.|..:.|::| |...:|   |..:.:::...:|.:|..:.|.
Frog    36 IRIGGIFEHLEGPTGQLVSAEEQAFRFSASIINRNRTLLPNTTLTYDIQRINLYDSFEANRKACD 100

  Fly    88 LMQSGVGAVFGPAARHTASHLLNACDSKDIPFIYPHLSWGSNP----DGF--NLHPSPEDIANAL 146
            .:..||.|:|||:...:::.:.:.|::.::|.|  .:.|..:|    |.|  ||:|....:::|:
Frog   101 QLALGVVAIFGPSHSSSSNAVQSICNALEVPHI--QVRWKHHPLDNRDSFYVNLYPDYASLSHAI 163

  Fly   147 YDIVNQFEWSRFIFCYESAEYLKILDHLMTRYGIKGPVIKVMRYDLNL--------NGNYKSVLR 203
            .|:|...:|......|:.:..|..|..|     |..|.    ||::.|        :.:.:.:|:
Frog   164 LDLVQFLKWRSATVVYDDSTGLIRLQEL-----IMAPA----RYNIRLKIRQLPPESEDARPLLK 219

  Fly   204 RIRKSEDSRIVVVGSTTGVAELLRQAQQVGIMNEDYTYIIGNLNLHTFDLEEYKYSEANITGIRM 268
            .:::..:.||:...|.|..|::||||..:|:|.|.|.||...|:|:..|||.|:||..|:||.|:
Frog   220 EMKRGREFRIIFDCSHTMAAQILRQAMAMGMMTEYYHYIFTTLDLYALDLEPYRYSGVNLTGFRI 284

  Fly   269 FSPDQEEVRDLMEKLHQELGESEP-VNSG--STFITMEMALTYDAVRVIAETTKHLPYQ--PQM- 327
            .:.|...|..:::|...|..::.| ..||  ...:|.:.|||||||.:::     :.||  |||
Frog   285 LNVDNPYVSSIVDKWSMERHQATPKPESGLLDGIMTTDAALTYDAVHIVS-----VCYQRAPQMT 344

  Fly   328 ---LNCSERHDNVQPDGSTFRNYMRSLEIKEKTITGRIYFE--GNVRKGFTFDVIELQTSGLVKV 387
               |.| .|| .....||.|.|:::  |.:.:.:||||.|.  ..:|..|..|:|.|:..||.||
Frog   345 VNSLQC-HRH-KAWRFGSRFMNFIK--EAQWEGLTGRIVFNKTSGLRTDFDLDIISLKEDGLEKV 405

  Fly   388 GTWEEGKDFEFQRPPQAVNFNDIDDG-------SLVNKTFIVLISVATKPYASLVESIDTLIGNN 445
            |||         .|...:|..:...|       ||.|:|.|| .:|..:||.....|...|.|.:
Frog   406 GTW---------NPSDGLNITETARGRGPNISESLTNRTLIV-TTVLEEPYVMFKRSDTPLFGKD 460

  Fly   446 QFQGYGVDLIKELADKLGFNFTFR---DGGNDYGSFNKTTNSTSGMLKEIVEGRADLAITDLTIT 507
            :|:|:.:||:|::|:.|||::..|   |.  .|||.:: ....:|::||:::.:||||:..||||
Frog   461 RFEGFCIDLLKKIAEILGFDYDIRLVEDA--KYGSQDE-KGQWNGLVKELIDHKADLAVAPLTIT 522

  Fly   508 SEREEVIDFSIPFMNLGIAILYVKPQKAPPALFSFMDPFSSEVWLYLGIAYLGVSLCFFIIGRLS 572
            ..||:|||||.|||.|||:|||.|.....|::|||::|.|.::|:|:.:||||||...|:|.|.|
Frog   523 HVREKVIDFSKPFMTLGISILYRKANGTAPSVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFS 587

  Fly   573 PIEWDNPYPCIEEPEELENQFTINNSLWFTTGALLQQGSEIAPKALSTRTISAIWWFFTLIMVSS 637
            |.||.:.:||....:.:||.||:.||.||..|||:|||||:.|||||||.|..||||||||::||
Frog   588 PYEWYDAHPCNPGTDVVENNFTLLNSFWFAVGALMQQGSELMPKALSTRIIGGIWWFFTLIIISS 652

  Fly   638 YTANLAAFLTIENPTSPINSVKDLADNKDDVQYGAKRTGSTRNFFSTSEEPIYIKMNEYLNAHPE 702
            ||||||||||:|...|.|:|..||| .:..::|||...|:|.|||..|....:.||..::::.|.
Frog   653 YTANLAAFLTVERMESAIDSADDLA-KQTKIEYGAVVDGATMNFFKKSHISTFEKMWAFMSSRPS 716

  Fly   703 MLMENNQQGVDKVKSGTKYAFLMESTSIEFNTVRECNLTKVGDPLDEKGYGIAMVKNWPYRDKFN 767
            .|:::|::|:.:|.| ..||.|||||:||:.|.|.||||::|..:|.|||||......||||:.:
Frog   717 ALVKSNEEGIQRVLS-ADYALLMESTAIEYITQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDRIS 780

  Fly   768 KALLELQEQGVLARLKNKWWNEVGAGVCSAKSDDDGPSELGVDNLSGIYVVLVIGSIISIIISIL 832
            .|:|:|||...:.::|.:||.   :|.|..:.:.:. |.||:.|:.||::||..|.|:|:::::.
Frog   781 IAILQLQEADEIHKMKERWWR---SGGCPEEKNKEA-SALGIQNMGGIFIVLAGGLILSVVVAMA 841

  Fly   833 CWCYFVYKKAKNYEVPFCDALAEEFRIVI----RFSENERPLKSAQSIYSRSRNSSQSIESLKTD 893
            .:.|.:.|.|:..:..||..:|:|.|:.:    |.....:|....:         |.::.::.|.
Frog   842 EFVYKLRKTAEREQRSFCSTMADEIRLSLTCQRRVKHKPQPPVMVK---------SDAVINMHTF 897

  Fly   894 SEENMPVED 902
            ::..:|.:|
Frog   898 NDRRLPGKD 906

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIID	NP_651982.1	PBP1_iGluR_Kainate	35..397	CDD:107377	117/397 (29%)
		ANF_receptor	46..380	CDD:279440	105/362 (29%)
		PBP2_iGluR_Kainate	417..788	CDD:270432	176/373 (47%)
		Lig_chan	549..819	CDD:278489	127/269 (47%)
grik3	XP_031752773.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.930