DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIID and grik4

DIOPT Version :9

Sequence 1:	NP_651982.1	Gene:	GluRIID / 44483	FlyBaseID:	FBgn0028422	Length:	902	Species:	Drosophila melanogaster
Sequence 2:	XP_031761990.1	Gene:	grik4 / 100490768	XenbaseID:	XB-GENE-1011875	Length:	962	Species:	Xenopus tropicalis

Alignment Length:	903	Identity:	299/903 - (33%)
Similarity:	473/903 - (52%)	Gaps:	76/903 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 EASSGQSIRLGLITDDATDRIRQTFEHAISVVNNELG--------VPLVGETEQVAYGNSVQAFA 83
            :::...|:|:..|.||..:..|.. ..:|::..|.:.        ..|..:..::...:..:...
Frog    17 KSAGSPSLRIAAILDDPMECSRGE-RLSITLAKNRINRAPERQGKARLEVDIFELLKDSEYETAE 80

  Fly    84 QLCRLMQSGVGAVFGPAARHTASHLL-NACDSKDIP-----------FIYPHLSWGSNPDGFNLH 136
            .:|:::..||..|.||:...::|.:: |.|..|::|           |.|...:      ..|||
Frog    81 TMCQILPKGVLGVLGPSYSPSSSSIISNICGEKEVPHIKVSTEEFLRFQYQRFT------TLNLH 139

  Fly   137 PSPEDIANALYDIVNQFEWSRFIFCYESAEYLKILDHLMTRYGIKGPVIKVMRYDLNLNGNYKSV 201
            ||..||:.|:..::..|..:........||.|..|:.|:.::.|....:.|...|...:..  .:
Frog   140 PSNTDISAAVATLLRFFNSTTACLICAKAECLLNLEKLLRQFLISKDCLSVRMLDDTWDPT--PL 202

  Fly   202 LRRIRKSEDSRIVVVGSTTGVAELLRQAQQVGIMNEDYTYIIGNLNLHTFDLEEYKY---SEANI 263
            |:.||..:.|.|:|..:.:....:|.:|.::|::...||||..||.   |.|:.::.   ...||
Frog   203 LKEIRDDKTSTIIVHANASMSHTILMKAAELGMVTAYYTYIFTNLE---FVLQRFESPLDDRVNI 264

  Fly   264 TGIRMFSPDQEEVRDLMEKLHQELGESEPVNSGSTFITMEMALTYDAVRVIAETTKHLPYQPQM- 327
            .|..||:......::....| |:..|....:|..|...:..||.:|||..|....:.|....::
Frog   265 LGFSMFNQSHSYFKEFAHTL-QQSWEENCDHSPFTGPALSAALLFDAVYGIVSAVQELNRSQEIG 328

  Fly   328 ---LNCSERHDNVQPDGSTFRNYMRSLEIKEKTITGRIYFEG-NVRKGFTFDVIELQTSGLVKVG 388
               |:|..  ..:...|::..||:|.:|:  :.:||.:.|.. ..|..:...:::...:|..::|
Frog   329 VKPLSCGS--SQIWQHGTSLMNYLRMVEL--EGLTGHVEFNSKGQRSNYDMKIMQYTKTGFQEIG 389

  Fly   389 TWEEGKDFEFQRPPQAVNFNDIDDGSLVNKTFIV---LISVATKPYASLVESIDTLIGNNQFQGY 450
            .|.........:...:.|.:|    :|||||.||   |..:...||..|..:...|.||::::|:
Frog   390 QWHVTNGLNMDKRYFSPNASD----TLVNKTLIVTTILFFLQENPYLMLKANHQELEGNDRYEGF 450

  Fly   451 GVDLIKELADKLGFNFTFR---DGGNDYGSFNKTTNSTSGMLKEIVEGRADLAITDLTITSEREE 512
            .||::||||..|.||:..|   ||.......|.|   .:||:.|::..:||||:..||||:|||:
Frog   451 CVDMLKELAAILRFNYKIRLVADGVYGVPELNGT---WTGMVGELISRKADLAVAGLTITAEREK 512

  Fly   513 VIDFSIPFMNLGIAILYVKPQKAPPALFSFMDPFSSEVWLYLGIAYLGVSLCFFIIGRLSPIEWD 577
            |||||.|||.|||:|||.......|..|||:||||..|||::.:|||.||...|::.||:|.||.
Frog   513 VIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPGVWLFMLLAYLAVSCVLFLVARLTPYEWY 577

  Fly   578 NPYPCIE-EPEELENQFTINNSLWFTTGALLQQGSEIAPKALSTRTISAIWWFFTLIMVSSYTAN 641
            :|:||.: ....|.||:::.|||||..|..:||||.|||:|||||.:|.:||.||||::||||||
Frog   578 SPHPCAQGRCNLLVNQYSLGNSLWFPVGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYTAN 642

  Fly   642 LAAFLTIENPTSPINSVKDLADNKDDVQYGAKRTGSTRNFFSTSEEPIYIKMNEYLNA-HPEMLM 705
            ||||||::....||.||.|||| :..::||....||:..||..|....|.:|..|::: .|.:.:
Frog   643 LAAFLTVQRMDVPIESVDDLAD-QTTIEYGTIHGGSSMTFFQNSRYQTYQRMWNYMHSKQPSVFV 706

  Fly   706 ENNQQGVDKVKSGTKYAFLMESTSIEFNTVRECNLTKVGDPLDEKGYGIAMVKNWPYRDKFNKAL 770
            ::.::|:.:|.: :.||||:|||..|:...|.||||:||..||.|||||.|.....:||:|:.|:
Frog   707 KSTEEGIARVLN-SNYAFLLESTMNEYYRQRNCNLTQVGGLLDTKGYGIGMPVGSAFRDEFDLAI 770

  Fly   771 LELQEQGVLARLKNKWWNEVGAGVCSAKSDDDGPSELGVDNLSGIYVVLVIGSIISIIISILCWC 835
            |:|||...|..||.|||:   .|.| .|.:|.....||::|:.||:|||:.|.|::|:|::|.:.
Frog   771 LQLQENNCLEDLKRKWWD---GGKC-PKEEDHRAKGLGMENIGGIFVVLICGLIVAILIAMLEFL 831

  Fly   836 YFVYKKAKNYEVPFCDALAEEFRIVIRFSENERPLKSAQSIY---------SRSRNSS 884
            :.| :.|::.||..|..:|.|...:|...::..|.:....:.         .|.||:|
Frog   832 WTV-RNAEDSEVSVCQEMASELSSIILCKDSFLPRRRRGGVIRGRPITQDDRRGRNTS 888

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIID	NP_651982.1	PBP1_iGluR_Kainate	35..397	CDD:107377	86/389 (22%)
		ANF_receptor	46..380	CDD:279440	79/361 (22%)
		PBP2_iGluR_Kainate	417..788	CDD:270432	177/378 (47%)
		Lig_chan	549..819	CDD:278489	125/271 (46%)
grik4	XP_031761990.1	Periplasmic_Binding_Protein_type1	23..400	CDD:415822	87/393 (22%)
grik4	XP_031761990.1	PBP2_iGluR_kainate_KA1	414..788	CDD:270442	177/378 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.020