Protein Alignment GluRIID and grin2b

DIOPT Version :9

• Sequence 1: NP_651982.1
• Gene: GluRIID / 44483
• FlyBaseID: FBgn0028422
• Length: 902
• Species: Drosophila melanogaster
• Sequence 2: XP_017948700.2
• Gene: grin2b / 100490580
• XenbaseID: XB-GENE-949327
• Length: 1449
• Species: Xenopus tropicalis
• Alignment Length: 933
• Identity: 212/933 - (22%)
• Similarity: 392/933 - (42%)
• Gaps: 199/933 - (21%)

  Fly     4 CW--ISLIILSLSRVQAQFYGGNAYEASSGQSIRLGLITDDATDRI-------RQTFEHAISVVN 59
            |:  ||||||        ||.| .| |....::.:.:|....||.:       :..|.|
 Frog     8 CYLKISLIIL--------FYMG-CY-AQKHPNMDIAVILVGTTDEVAIKDVHEKDDFHH------ 56

  Fly    60 NELGVPLVGETEQVAYGNS--VQAFAQLCRLM--QSGVGAVFGPAARHTASHLLNACDSKDIPFI 120
                :|:......|....|  .....::|.||  :...|.|||......|  :....|...:..:
 Frog    57 ----LPVTPRVALVTMNESDPKSIITRICDLMSDKKVQGVVFGDDTDQEA--IAQILDFISVQTL 115

  Fly   121 YPHLS--WGSN---PDG------FNLHPSPEDIANALYDIVNQFEWSRFIFC--------YESAE 166
            .|.|.  .||:   .|.      |...||.|..|:.:.:|:.:::|  :||.        |:..|
 Frog   116 TPILGIHGGSSMIMADKEEASMFFQFGPSIEQQASVMLNIMEEYDW--YIFSIVTTYFPGYQDFE 178

  Fly   167 YLKILDHLMTRYGIKGPVIKVMRYDLNLNGNYKSVLRRIRKSEDSRIVVVGSTTGVAELLRQAQQ 231
            . |:...:...: :...:.:|:..|::|:.|...:..:::|.:...|::..:......:...|..
 Frog   179 N-KVRSTIENSF-VGWELEEVIHLDMSLDDNDSKIQNQLKKLQSPVILLYCTKEEATYIFEVAHS 241

  Fly   232 VGIMNEDYTYIIGNLNLHTFDLEEYKYSEANITGIRMFSPDQ------EEVRD----------LM 280
            ||:....||:|:.:|.....|....::.    ||:...|.|:      ..|||          .|
 Frog   242 VGLTGYGYTWIVPSLVAGDTDTVPAEFP----TGLISVSYDEWDYDLPARVRDGIAIITTAASTM 302

  Fly   281 EKLHQELGESEPVNSGSTFITMEMALTYDAVRVIAETTKHLPYQPQMLNCSERHDNVQPD----- 340
            ...|..:.:|:     |:...::.:..|:| .::.....::.::.:.|:.||....:.|.
 Frog   303 LSEHNSIPQSK-----SSCYNIQESRVYEA-HMLKRYLINVTFEGRNLSFSEDGYQMHPKLVIIL 361

  Fly   341 GSTFRNYMRSLEIKEKTITGRIYFEGNVRKGFTFDVIELQTSGLVKVGTWEEGKDFEFQRPPQAV 405
            .:..|.:.|..:.|::::..:.|         .:.|.||..:.       ||.||
 Frog   362 LNQQRKWERVGKYKDRSLKMKYY---------VWPVFELYPNS-------EEHKD---------- 400

  Fly   406 NFNDIDDGSLVNKTFIVLISVATKPYASLVESIDTLIG---------------NNQFQ------- 448
                         ..:.::::...|:. :||.:|.|.|               .|:.:
 Frog   401 -------------EHLSIVTLEEAPFV-IVEDVDPLSGTCMRNTVPCRKQIRTENRTEEGGNYIK 451

  Fly   449 ----GYGVDLIKELADKLGFNFTFRDGGNDYGSFNKTTNST-SGMLKEIVEGRADLAITDLTITS 508
                |:.:|::|::|..:.|.:......|  |...|..|.| :||:.|:|..||.:|:..|||..
 Frog   452 RCCKGFCIDILKKIAKTVKFTYDLYLVTN--GKHGKKINGTWNGMIGEVVTKRAYMAVGSLTINE 514

  Fly   509 EREEVIDFSIPFMNLGIAILYVKPQKAPPALFSFMDPFSSEVWLYLGIAYLGVS-LCFFIIGRLS 572
            ||.||:|||:||:..||::: |.......:..:|::|||::||:.:.:..|.|| :..|:....|
 Frog   515 ERSEVVDFSVPFIETGISVM-VSRSNGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFS 578

  Fly   573 PIEWDNPYPCIEEPEELEN-QFTINNSLWFTTGALLQQGSEIA-PKALSTRTISAIWWFFTLIMV 635
            |:.::.   |:.:..|... .|||..::|...|.:......:. ||..:::.:.::|.||.:|.:
 Frog   579 PVGYNR---CLADGREPGGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFL 640

  Fly   636 SSYTANLAAFLTIENPTSPINSVKDLADNK----DD----VQYGAKRTGST-RNFFSTSEEPIYI 691
            :|||||||||:..|   ..::.|..|:|.|    :|    .::|....||| ||.
 Frog   641 ASYTANLAAFMIQE---EYVDQVSGLSDKKFQRPNDFSPAFRFGTVPNGSTERNI---------- 692

  Fly   692 KMNEYLNAHPEMLMENN---QQGVDKVKSGTKYAFLMESTSIEFNTVRE--CNLTKVGD--PLDE 749
             .|.||..|..|:..|.   |..:..:|:|...||:.::..:.:...|:  |.|..:|.  ....
 Frog   693 -RNNYLEMHSYMVKFNQRSVQDALLSLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFAT 756

  Fly   750 KGYGIAMVKNWPYRDKFNKALLELQEQGVLARLKNKWWNEVGAGVCSAKSDDDGPSELGVDNLSG 814
            .|||||:.|:..::.:.:.|:|:|...|.:..|:..|.    .|:|..:.::...|:|.:||::|
 Frog   757 TGYGIAIQKDSGWKRQVDLAILQLFGDGEMEELEALWL----TGICHNEKNEVMSSQLDIDNMAG 817

  Fly   815 IYVVLVIGSIISIIISILCWCYF 837
            ::.:|.....:|:|..|:...:|
 Frog   818 VFYMLAAAMALSLITFIMEHLFF 840

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIID	NP_651982.1	PBP1_iGluR_Kainate	35..397	CDD:107377	76/412 (18%)
		ANF_receptor	46..380	CDD:279440	68/384 (18%)
		PBP2_iGluR_Kainate	417..788	CDD:270432	112/416 (27%)
		Lig_chan	549..819	CDD:278489	76/288 (26%)
grin2b	XP_017948700.2	PBP1_iGluR_NMDA_NR2	28..383	CDD:380601	68/380 (18%)
		PBP2_iGluR_NMDA_Nr2	400..800	CDD:270436	115/447 (26%)
		NMDAR2_C	837..1449	CDD:402274	1/4 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910