DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GluRIID and LOC100149482

DIOPT Version :9

Sequence 1:	NP_651982.1	Gene:	GluRIID / 44483	FlyBaseID:	FBgn0028422	Length:	902	Species:	Drosophila melanogaster
Sequence 2:	XP_009290417.1	Gene:	LOC100149482 / 100149482	-ID:	-	Length:	1959	Species:	Danio rerio

Alignment Length:	888	Identity:	201/888 - (22%)
Similarity:	373/888 - (42%)	Gaps:	212/888 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 GLITDD------ATDRIRQTFEHAISVVNNELGVPLVGETEQVAYGNSVQAFAQLCRLMQSGVGA 95
            ||:.:|      ||..:....|    .|:.:.|:|:|          :|...|.|.|:.|.. |:
Zfish   121 GLVYEDERPLPLATGPLAPMLE----FVSAQTGLPIV----------AVGGGAALGRVPQES-GS 170

  Fly    96 VFGPAARHTASHLLNACDSKDIPFIYPHLSWGSNPDGFNLHPSPEDIANALYDIVNQFEWSRFIF 160
            :|...:..||..|                                   ..:::::.:::|:.|..
Zfish   171 IFLQFSSSTALQL-----------------------------------EVIFEVLEEYDWTAFSV 200

  Fly   161 C------YESAEYLKILDHLMTRYGI---KGPVIKVMRYDLNLNGNYKSV-LRRIRKSEDSRIVV 215
            .      |:  ::|.:::.|.....|   |..::.     |||..:...| .:|:.|..::::.:
Zfish   201 VSTRHHGYQ--DFLSVVEGLTDGSFIGWEKKSIVM-----LNLTDDPGGVRTQRLLKENEAQVRL 258

  Fly   216 VGSTTGVAELLRQAQQVGIMNEDYTYIIGNLNL-HTFDLEEYKYSEANITGI--RMFSPDQEEVR 277
            :..:.      .:|:||.:.    .:..|.... |.:.......||..:||:  |:|:...:..|
Zfish   259 LYCSQ------EEAEQVFLA----AWAAGQAGASHIWFAVGPALSELGLTGLPKRLFAVRPQGWR 313

  Fly   278 DLMEKLHQELGESEPVNSGSTFITMEMALTYDAVRVI----AETTKHLPYQPQMLNCSERHDNVQ 338
            |            ||....:..:::   ||:.||.:.    |....|.     :.||       |
Zfish   314 D------------EPRRRIARGVSI---LTHGAVALRKDYGATGGPHF-----VTNC-------Q 351

  Fly   339 PDGS-TFRNYMRSLEIKEKTITGRIYF---EGNVRKGFTFDVIELQT-SGLVKVGTWEEG----- 393
            .||: |.|...|.......|:.||.|.   ||.:...| .|||.... ||...||.||.|
Zfish   352 TDGNRTQRIRGRMRYFSNITLGGRDYSFSNEGYLANPF-LDVISYTPGSGWEDVGWWENGVLRLR 415

  Fly   394 -----KDFEFQRPPQAVNFNDIDDGSLVNKTFIVLISVATKPYASLVESIDTLIG---------- 443
                 :...|.:||        ||..     .:.::::..:|:. :||..|...|
Zfish   416 YPAWSRYGPFLQPP--------DDAQ-----HLRVVTLEERPFV-IVELADAASGTCIRDSVPCR 466

  Fly   444 ---------------NNQFQGYGVDLIKELADKLGFNFTFRDGGNDYGSFNKTTNST-SGMLKEI 492
                           ....:|:.:|::|.||..:||.:......|  |...|..:.. :||:.|:
Zfish   467 RPLNASALQEGVAPVKQCCKGFCIDILKRLARIVGFTYDLYLVTN--GKHGKKIDGVWNGMVGEV 529

  Fly   493 VEGRADLAITDLTITSEREEVIDFSIPFMNLGIAILYVKPQKAPPALFSFMDPFSSEVWLYLGIA 557
            |..|||:||..|||..||.||:|||:||:..||::: |.......:..:|::|:|..||:.:.:.
Zfish   530 VYKRADMAIGSLTINEERSEVVDFSVPFVETGISVM-VSRSNGTVSPSAFLEPYSPAVWVMMFVM 593

  Fly   558 YLG-VSLCFFIIGRLSPIEWDNPYPCIEEPEEL-ENQFTINNSLWFTTGALLQQGSEIA-PKALS 619
            .|. |::..||....||:.::.   .::..::. .::|||..|:|.....:......:. ||..:
Zfish   594 CLTVVAVTVFIFEFFSPVGYNR---SLQSGKKAGGSKFTIGKSIWLLWALVFNNSVPVENPKGTT 655

  Fly   620 TRTISAIWWFFTLIMVSSYTANLAAFLTIENPTSPINSVKDLADNK--------DDVQYGAKRTG 676
            ::.:..:|.||.:|.::|||||||||:..|   ..|::|..|:|.|        ..:::|....|
Zfish   656 SKIMVLVWAFFAVIFLASYTANLAAFMIQE---EYIDTVSGLSDKKFQHPTEQYPPLKFGTVPNG 717

  Fly   677 ST-RNFFSTSEEPIYIKMNEYLNAHPEMLMENNQQGVDKVKSGTKYAFLMESTSIEFNTVRE--C 738
            || :|..|.     |..|::|:..:.:..:|:   .:..:|:|...||:.::..:.:...::  |
Zfish   718 STEKNIRSN-----YPDMHQYMVKYNQKSVED---AISHLKTGKLDAFIYDAAVLNYMARKDEGC 774

  Fly   739 NLTKVGD--PLDEKGYGIAMVKNWPYRDKFNKALLELQEQGVLARLKNKWWNEVGAGVCSAKSDD 801
            .:..:|.  .....|||||::||..::...:.|||:|.....:..|:..|.    :|:|.....:
Zfish   775 KVMTIGSGKVFATTGYGIALIKNSRWKRPLDLALLQLVGDDEIEMLERLWL----SGICHNDKIE 835

  Fly   802 DGPSELGVDNLSGIYVVLVIGSIISIIISILCWCYFVYKKAKN 844
            ...|:|.:||::|::.:|::...:|::  :..|.:.||.:.::
Zfish   836 VMSSKLDIDNMAGVFYMLLVAMGLSLL--VFAWEHLVYWRLRH 876

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIID	NP_651982.1	PBP1_iGluR_Kainate	35..397	CDD:107377	79/397 (20%)
		ANF_receptor	46..380	CDD:279440	67/354 (19%)
		PBP2_iGluR_Kainate	417..788	CDD:270432	105/412 (25%)
		Lig_chan	549..819	CDD:278489	70/285 (25%)
LOC100149482	XP_009290417.1	PBP1_iGluR_NMDA_NR2	44..421	CDD:107373	79/394 (20%)
		PBP2_iGluR_NMDA_Nr2	433..831	CDD:270436	107/424 (25%)
		HisJ	<487..>570	CDD:223904	34/85 (40%)
		Lig_chan	585..857	CDD:278489	71/289 (25%)
		NMDAR2_C	868..>900	CDD:287527	2/9 (22%)
		FAM76	<1763..>1856	CDD:292665
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591296
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740