DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIID and gria3

DIOPT Version :9

Sequence 1:	NP_651982.1	Gene:	GluRIID / 44483	FlyBaseID:	FBgn0028422	Length:	902	Species:	Drosophila melanogaster
Sequence 2:	NP_001106494.1	Gene:	gria3 / 100127683	XenbaseID:	XB-GENE-1010483	Length:	887	Species:	Xenopus tropicalis

Alignment Length:	856	Identity:	284/856 - (33%)
Similarity:	456/856 - (53%)	Gaps:	81/856 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 SIRLGLITDDATDRIRQTFEHAISVVNNELGVPLVGETEQVAYGNSVQAFAQLCRLMQSGVGAVF 97
            :::|.....:.|:|..|.|.|                .:.:...||.......|.....||.|:|
Frog    48 AVQLHNTNQNNTERPFQLFHH----------------VDHLDSSNSFSVTNAFCSQFSRGVYAIF 96

  Fly    98 GPAARHTASHLLNACDSKDIPFIYPHLSWGSNPD-GFNLHPSPEDIANALYDIVNQFEWSRFIFC 161
            |...:.:.:.|.:.|.:....||.|  |:.::.| .|.:...| .:..|:..::|:::|.:|::.
Frog    97 GFYDQMSMNTLTSFCGALHTSFITP--SFPTDADVQFVIQMRP-PLKGAILTLLNEYDWQKFVYL 158

  Fly   162 YESAEYLKILDHLMTRYGIKGPVIKVMRYDLNLNGN------YKSVLRRIRKSEDSRIVVVGSTT 220
            |::.....||..:|     :..|....:......||      :|.::..:.:.::.|.|:.....
Frog   159 YDTERGFSILQAIM-----EAAVQNNWQVTARSVGNIKDVQEFKRIIEEMDRRQEKRFVIDCEVE 218

  Fly   221 GVAELLRQAQQVGIMNEDYTYIIGNLNLHTFDLEEYKYSEANITGIRMFSPDQEEVRDLMEKLHQ 285
            .:..:|.|...:|.....|.|::.||....|.||...:..||:||.::.:.:...|:..::: ..
Frog   219 RINTILEQVVILGKHTRGYHYMLANLGFTGFTLERVMHGGANVTGFQIVNNENPIVQQFLQR-WV 282

  Fly   286 ELGESEPVNSGSTFITMEMALTYDAVRVIAETTKHLPYQPQMLNCSERHD------NVQPDGSTF 344
            .|.|.|...:.:|.:....|||:|||.||||..::|  :.|.::.|.|..      |.....|..
Frog   283 RLDEREFPEARNTPLKYTSALTHDAVLVIAEAFRYL--RRQRVDVSRRGSAGDCLANPAVPWSQG 345

  Fly   345 RNYMRSLE-IKEKTITGRIYFEGNVRK-GFTFDVIELQTSGLVKVGTWEEGKDFEFQRPPQAVNF 407
            .:..|:|: ::.:.:||.|.|:...|: .:|.||.|:..:...|||.|.|.:.|......|..|
Frog   346 IDIERALKMVQVQGMTGNIQFDTYGRRTNYTIDVYEMTATKPRKVGHWNEYERFVPAPDQQPTN- 409

  Fly   408 NDIDDGSLVNKTFIVLISVATKPYASLVESIDTLIGNNQFQGYGVDLIKELADKLGFNFTF---R 469
               :..|:.||| |::.::...||....::.:.|.||::::||.|||..|:|..:|..:..   .
Frog   410 ---ESSSVENKT-IIVTTILENPYVMKKKNHELLDGNDKYEGYCVDLASEIAKHVGIKYKLSIVE 470

  Fly   470 DGGNDYGSFNKTTNSTSGMLKEIVEGRADLAITDLTITSEREEVIDFSIPFMNLGIAILYVKPQK 534
            ||  .||:.:..|...:||:.|:|.||||:|:..||||..||||||||.|||:|||:|:..||||
Frog   471 DG--KYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQK 533

  Fly   535 APPALFSFMDPFSSEVWLYLGIAYLGVSLCFFIIGRLSPIEWD--------NPYPCIEEPEELEN 591
            :.|.:|||:||.:.|:|:.:..||:|||:..|::.|.||.||.        :|    :.|.:..|
Frog   534 SKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDTDEARDP----QNPPDPPN 594

  Fly   592 QFTINNSLWFTTGALLQQGSEIAPKALSTRTISAIWWFFTLIMVSSYTANLAAFLTIENPTSPIN 656
            :|.|.|||||:.||.:|||.:|:|::||.|.:..:|||||||::||||||||||||:|...|||.
Frog   595 EFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIE 659

  Fly   657 SVKDLADNKDDVQYGAKRTGSTRNFFSTSEEPIYIKMNEYL-NAHPEMLMENNQQGVDKV-KSGT 719
            |.:||| .:.::.||...:|||:.||..|:..:|.||..|: :|.|.:..:....||.:| ||..
Frog   660 SAEDLA-KQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTDDGVARVRKSKG 723

  Fly   720 KYAFLMESTSIEFNTVRE-CNLTKVGDPLDEKGYGIAMVKNWPYRDKFNKALLELQEQGVLARLK 783
            |:|||:|||..|:...|: |:..|||..||.||||:|..|........|.|:|:|.|||:|.:||
Frog   724 KFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALGTPVNLAVLKLSEQGILDKLK 788

  Fly   784 NKWWNEVGAGVCSAK--SDDDGPSELGVDNLSGIYVVLVIGSIISIIISILCWCY---------F 837
            ||||.:  .|.|.||  ...|..|.|.:.|::|::.:||.|..::::::::.:||         .
Frog   789 NKWWYD--KGECGAKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIEFCYKSRAESKRMK 851

  Fly   838 VYKKAKNYEVP 848
            :.|.|:|::.|
Frog   852 LTKNAQNFKPP 862

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIID	NP_651982.1	PBP1_iGluR_Kainate	35..397	CDD:107377	88/376 (23%)
		ANF_receptor	46..380	CDD:279440	81/348 (23%)
		PBP2_iGluR_Kainate	417..788	CDD:270432	173/384 (45%)
		Lig_chan	549..819	CDD:278489	123/282 (44%)
gria3	NP_001106494.1	Periplasmic_Binding_Protein_Type_1	29..400	CDD:324556	88/378 (23%)
gria3	NP_001106494.1	PBP2_iGluR_AMPA	416..798	CDD:270433	175/391 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.100