DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIID and gria1

DIOPT Version :9

Sequence 1:	NP_651982.1	Gene:	GluRIID / 44483	FlyBaseID:	FBgn0028422	Length:	902	Species:	Drosophila melanogaster
Sequence 2:	XP_004912781.1	Gene:	gria1 / 100127569	XenbaseID:	XB-GENE-995621	Length:	903	Species:	Xenopus tropicalis

Alignment Length:	853	Identity:	292/853 - (34%)
Similarity:	470/853 - (55%)	Gaps:	69/853 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 IRLGLITDDATDRIRQTFEHAISVVNNELGVP--LVGETEQVAYGNSVQAFAQLCRLMQSGVGAV 96
            |::|.:..:...:....|..|:|    :|..|  |:.:.:.|...:|.:.....|.....||.|:
Frog    25 IQIGGLFPNQQSQEHAAFRFALS----QLSEPPKLLPQIDIVNISDSFEMTYTFCSQFSKGVYAI 85

  Fly    97 FGPAARHTASHLLNACDSKDIPFIYPHLSWGSNPDGFNLHPSPEDIANALYDIVNQFEWSRFIFC 161
            ||...|.|.:.|.:.|.:..:.||.|.....:: :.|.|...|| :.:||..::..::|.:|::.
Frog    86 FGFYDRKTVNMLTSFCGALHVCFITPSFPVATS-NQFVLQLRPE-LQDALISVIEYYKWKKFVYI 148

  Fly   162 YESAEYLKILDHLMTRYGIKGPVIKVMRYDLNLNGNYKSVLRRIRKSEDSRIVVVGSTTGVAELL 226
            |::...|.:|..::.....|...:..:.........|:.:.:.:.||:|.:||:...:..:..:|
Frog   149 YDADRGLSVLQKVLDTAAEKNWQVTAVNILTTTEEGYRLLFQDLDKSKDRQIVIDCESERLNAIL 213

  Fly   227 RQAQQVGIMNE----DYTYIIGNLNLHTFDLEEYKYSEANITGIRMFSPDQEEVRDLMEKLHQEL 287
               .||.:..|    .|.||:.||.....|::::|.:.||:||.::.:.....|..:|::.....
Frog   214 ---TQVVVKLEKNIIGYHYILANLGFMDIDMQKFKEAGANVTGFQLVNYTDTMVSRIMQQWKNYD 275

  Fly   288 GESEP-VNSGSTFITMEMALTYDAVRVIAETTKHLPYQPQMLNCSERHDNVQPDGSTFRN----- 346
            |..:| |:......|  .|||||.|||:||..:.|  :.|.::.|.|.:    .|....|
Frog   276 GREQPRVDWKKPKYT--SALTYDGVRVMAEAFQSL--RKQRIDISRRGN----AGDCLANPAVPW 332

  Fly   347 -----YMRSL-EIKEKTITGRIYF-EGNVRKGFTFDVIELQTSGLVKVGTW-EEGKDFEFQRPPQ 403
                 ..|:| :::.:.::|.:.| |...|..:|..|:||:..|:..:..| |:.|........|
Frog   333 GQGIDIQRALQQVRLEGLSGNVQFNEKGRRTNYTLHVLELKHEGIRHIAHWNEDDKLIPLATDAQ 397

  Fly   404 AVNFNDIDDGSLVNKTFIVLISVATKPYASLVESIDTLIGNNQFQGYGVDLIKELADKLGFNFTF 468
            |.|    |...:.|:|:|| .::...||..|.::.|.|.||::|:||.|:|..|:|..:||.:..
Frog   398 AGN----DTIGVQNRTYIV-TTILEAPYVMLKKNADQLEGNDRFEGYCVELAAEIAKHVGFKYKL 457

  Fly   469 ---RDGGNDYGSFNKTTNSTSGMLKEIVEGRADLAITDLTITSEREEVIDFSIPFMNLGIAILYV 530
               :||  .||:.:....:.:||:.|:|.||||||:..||||..||||||||.|||:|||:|:..
Frog   458 EIVKDG--KYGARDSDMKAWNGMVGELVYGRADLAVAPLTITLVREEVIDFSKPFMSLGISIMIK 520

  Fly   531 KPQKAPPALFSFMDPFSSEVWLYLGIAYLGVSLCFFIIGRLSPIEWDNPYPCIEEPEE------- 588
            ||||:.|.:|||:||.:.|:|:.:..||:|||:..|::.|.||.||.|     ||.||
Frog   521 KPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHN-----EEFEEGKEQPTT 580

  Fly   589 -LENQFTINNSLWFTTGALLQQGSEIAPKALSTRTISAIWWFFTLIMVSSYTANLAAFLTIENPT 652
             ..|:|.|.|||||:.||.:|||.:|:|::||.|.:..:|||||||::||||||||||||:|...
Frog   581 DQSNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMV 645

  Fly   653 SPINSVKDLADNKDDVQYGAKRTGSTRNFFSTSEEPIYIKMNEYL-NAHPEMLMENNQQGVDKV- 715
            |||.|..||| .:.::.||...:|||:.||..|:..::.||..|: :|.|.:.::..::|:::|
Frog   646 SPIESADDLA-KQTEIAYGTLDSGSTKEFFKRSKIAVFEKMWTYMRSAEPSVFVKTTEEGMNRVR 709

  Fly   716 KSGTKYAFLMESTSIEFNTVRE-CNLTKVGDPLDEKGYGIAMVKNWPYRDKFNKALLELQEQGVL 779
            ||..|||:|:|||..|:...|: |:..|||..||.||||||..|..|.|...|.|:|:|.|||||
Frog   710 KSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSPLRGAVNLAVLKLSEQGVL 774

  Fly   780 ARLKNKWWNEVGAGVCSAK--SDDDGPSELGVDNLSGIYVVLVIGSIISIIISILCWCYFVYKKA 842
            .:||:|||.:  .|.|.:|  ...|..|.|.:.|::|::.:|:.|..::::::::.:||....::
Frog   775 DKLKSKWWYD--KGECGSKDSGSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIEFCYKSRSES 837

  Fly   843 KNYEVPFC 850
            |..: .||
Frog   838 KKMK-GFC 844

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIID	NP_651982.1	PBP1_iGluR_Kainate	35..397	CDD:107377	91/381 (24%)
		ANF_receptor	46..380	CDD:279440	85/352 (24%)
		PBP2_iGluR_Kainate	417..788	CDD:270432	180/384 (47%)
		Lig_chan	549..819	CDD:278489	126/282 (45%)
gria1	XP_004912781.1	PBP1_iGluR_AMPA_GluR1	26..393	CDD:380613	91/383 (24%)
gria1	XP_004912781.1	PBP2_iGluR_AMPA_GluR1	407..788	CDD:270447	182/391 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000