DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIID and grid1

DIOPT Version :9

Sequence 1:	NP_651982.1	Gene:	GluRIID / 44483	FlyBaseID:	FBgn0028422	Length:	902	Species:	Drosophila melanogaster
Sequence 2:	NP_001096470.1	Gene:	grid1 / 100125089	XenbaseID:	XB-GENE-990290	Length:	1009	Species:	Xenopus tropicalis

Alignment Length:	865	Identity:	213/865 - (24%)
Similarity:	403/865 - (46%)	Gaps:	102/865 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 IRLGLITDDATDRIRQTFEHAIS--VVNNELGVPLVGETEQVAY-------GNSVQAFAQLCRLM 89
            |.:|.|.::...:..:.|:.|:|  .:|::     :.::|::.|       .|..||..:.|.||
Frog    24 IHIGAIFEENAVKDDEVFQLAVSDLSLNDD-----ILQSEKITYSIKFIEANNPFQAVQEACDLM 83

  Fly    90 QSGVGAVFGPAARHTASHLLNACDSKDIPFIYPHLSWGSNPD---GFNLHPSPED---------- 141
            ..|:.|:.......:|:.|.:..|:..||.|:...:.|.:|.   .||  ||||.
Frog    84 TQGILALVTSTGCASANALQSLTDAMHIPHIFVQRNSGGSPRTVCQFN--PSPEGEEYTLAARPP 146

  Fly   142 --IANALYDIVNQFEWSRFIFCYESAEYLKILDHLMTRYGIKGPVIKVMRYDLNLNGNYKSVLRR 204
              :.:.:..:|.:..|.:||..|:|...::.|...:.:....|..:.:.:.|.|::..:.::...
Frog   147 VRLNDVMLKLVTELRWQKFIVFYDSDYDIRGLQGFLDQASRLGLDVSLQKVDRNISRVFATLFTS 211

  Fly   205 IRKSE-----DS--RIVVVGSTTGVAELLRQAQQVGIMNEDYTYIIGNLNLHTFDLEEYKYSE-A 261
            ::..|     |:  |.:::.|..|....:.:|.:..:.::|..::..|..::..::.|..:|. .
Frog   212 MKTEELNRYRDTLRRAILLLSPRGAQSFISEAVETNLASKDSHWVYVNEEINDAEIVELVHSALG 276

  Fly   262 NITGIRMFSPDQEE--VRDLMEKLHQELGESEPVNSGSTFITMEMALTYDAVRVIA-------ET 317
            .||.||...|..::  :|.:...........:|.......:.:.....||:|.::|       |.
Frog   277 RITVIRQIFPSLKDNNIRCVRNNHRIASLPCDPQEGYLQMLQVSNLYLYDSVLMLANAFHRKLED 341

  Fly   318 TKHLPYQPQMLNCSERHDNVQPDGSTFRNYMRSL--EIKEKTITGRI----YFEGNVRKGFTFDV 376
            .|.  :....|||..:.......|       ||:  .||:..|||..    :.|........|::
Frog   342 RKW--HSMASLNCMRKSTKPWNGG-------RSMLDTIKKGRITGLTGIMEFKEAGANPHVQFEI 397

  Fly   377 IEL---QTSG--LVKVGTWEEGKDFEFQRPPQAVNFNDIDDGSLVNKTFIVLISVATKPYASLVE 436
            :..   :|.|  :.::.||:..|.|......:.:| ||:...:|      .:::|..:|:..:.|
Frog   398 LGTSYSETFGKDVRRLATWDSMKGFNGSLQEKPLN-NDLQGLTL------KVVTVLEEPFVMVAE 455

  Fly   437 SIDTLIGN-NQFQGYGVDLIKELADKLGFNFTFRDGGNDYGSFNKTTNSTSGMLKEIVEGRADLA 500
            :|   :|. .:::|:.::::.||:::|||.:......:.......:..|.:||:.|::..|||:|
Frog   456 NI---LGQPKRYKGFSIEILDELSNRLGFKYEIYQAPDGKYGHQLSNGSWNGMIGELINKRADIA 517

  Fly   501 ITDLTITSEREEVIDFSIPFMNLGIAILYVKPQKAPPALFSFMDPFSSEVWLYLGIAYLGVSLCF 565
            |:.:|||.|||.|:||:..:::..:.||..||::. ..:||...||...||..:......|.:..
Frog   518 ISAITITPERENVVDFTKRYLDYSVGILIKKPEER-INIFSLFAPFDFAVWACIAAVIPVVGVLI 581

  Fly   566 FIIGRLSPIEWDNPYPCIEEPEELENQFTINNSLWFTTGALLQQGSEIAPKALSTRTISAIWWFF 630
            |::.|:..:...|     ..........|:::::|...||.:|||.|.|..:::.|.:...||.|
Frog   582 FVLNRIQAVRAQN-----SSQTSQSTSSTLHSAIWIVYGAFVQQGGESAANSVAMRIVMGSWWLF 641

  Fly   631 TLIMVSSYTANLAAFLTIENPTSPINSVKDLADNKDDVQYGAKRTGSTRNFFSTSEEPIYIKMNE 695
            |||:.||||||||||||:....:||.:.:||| .:.|:.||..:..|...:|.:......::...
Frog   642 TLIVCSSYTANLAAFLTVSRMDNPIRTFQDLA-KQVDLPYGTVKDSSVYEYFKSKGTNTLVQDRT 705

  Fly   696 YL--------NAHPEMLMENNQQGVDKVKSGTKYAFLMESTSIEFN--TVRECNLTKVGDPLDEK 750
            :.        |...:..:.:..:|:.|.|.| .||||.:.|.:|:.  |..||::...|:.:..|
Frog   706 FAELWRTIGKNNGSDNCVSSPSEGIRKAKRG-NYAFLWDVTVVEYAALTDDECSVAVTGNTISSK 769

  Fly   751 GYGIAMVKNWPYRDKFNKALLELQEQGVLARLKNKWWNEVGAGVCSAKSDDDGPSE---LGVDNL 812
            |||||:....||||.|::.:||.|:.|.|..||.|||...|.  |...|.::..::   |.:.:.
Frog   770 GYGIALQHGSPYRDIFSQRILEFQDSGRLDVLKEKWWPRTGR--CDLNSHNNAQNDGKALKLHSF 832

  Fly   813 SGIYVVLVIGSIISIIISIL 832
            :|::.:|.||.:::.:::.|
Frog   833 AGVFCILAIGLLLACLVAAL 852

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIID	NP_651982.1	PBP1_iGluR_Kainate	35..397	CDD:107377	81/413 (20%)
		ANF_receptor	46..380	CDD:279440	74/383 (19%)
		PBP2_iGluR_Kainate	417..788	CDD:270432	116/381 (30%)
		Lig_chan	549..819	CDD:278489	85/282 (30%)
grid1	NP_001096470.1	PBP1_iGluR_delta_1	25..424	CDD:107387	82/414 (20%)
		ANF_receptor	39..400	CDD:279440	74/376 (20%)
		PBP2_iGluR_delta_1	437..807	CDD:270448	117/386 (30%)
		Lig_chan	565..842	CDD:278489	86/285 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000