DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ear and FYV8

DIOPT Version :9

Sequence 1:	NP_001262595.1	Gene:	ear / 44451	FlyBaseID:	FBgn0026441	Length:	945	Species:	Drosophila melanogaster
Sequence 2:	NP_011712.1	Gene:	FYV8 / 853110	SGDID:	S000003428	Length:	817	Species:	Saccharomyces cerevisiae

Alignment Length:	818	Identity:	166/818 - (20%)
Similarity:	296/818 - (36%)	Gaps:	195/818 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   250 GREK------ASKDRDKSSGGDKPREKDKKDRHGRDKDRKSSKSGDGKHERDKEKSK------KD 302
            ||:|      ||:.....:|.|...|.|           .||:.|....|..|:|..      |.
Yeast     7 GRKKSYRWVSASQASYDGAGWDSSDEYD-----------YSSEDGTKGSEIHKQKISNLPSLPKL 60

  Fly   303 KSRDKEREREQGSGNTTSANALTVATS--------VG-TAGGLVKHTASPKPGKPNEMGAPSPKK 358
            ...|...|.::.:|....:|...|:.|        || .:.|:.|..||      .|......||
Yeast    61 NYTDVNGEHDENTGENKDSNDNNVSKSDISPSDKEVGYLSDGVPKLMAS------RESVELQAKK 119

  Fly   359 TANDSAAGAVAPTSRSKERDEHKS------VKSESKDK--ERSSSKKSKKDKKDKDKQRD-ESKD 414
            ::..|.:..::.|:..|...|:|.      ..:|..|.  |:.|.:.:.:.::..|.:|| :|.|
Yeast   120 SSEHSKSDYLSSTASLKSPSENKKSPHTNRAVNEDLDNLIEQISREMTPEIRQTSDFRRDSDSCD 184

  Fly   415 K---RMPKDERPGQSDSPASGNLQSAHL--QQQSQVASTGKATPTSVGSNSSSSMVSNIGKQKEE 474
            :   ..|..|....|.||...:.:|..|  ...:..|.|...|||..| |...|...::.:||::
Yeast   185 EIQNEAPLGEAVPSSSSPVEEDEKSHSLGVSMDTNEADTTFNTPTRNG-NEHLSSDGDVSEQKDD 248

  Fly   475 ATGKHSEKA-----AESKGDKSTSNGNATDTKKSHKHKKKEKSKDKE--KERNDRDKDKDKERDK 532
            .. |.||:.     ..::.:::....:..:.:.|...:|||||::|.  :.||.....:||....
Yeast   249 EF-KVSERGYLADILPAEKEENLQQEDDGEVESSGALEKKEKSEEKTSIRNRNSTSSGQDKVAKP 312

  Fly   533 DKLKEREK------------DKQHVTGSE----------------KSSTVDPSPKLEGASPATEG 569
            ..:....|            |.||.:.||                :||..|....:...|...:.
Yeast   313 KPVANETKTSDNGYRNSFFNDYQHSSDSEEDDNNEGNSGSSDDDNRSSVSDKHADINRQSKQLDT 377

  Fly   570 GAPDKTPVSASASSGSKKEKHKKSKEKSSGKDEKRQREAV-DKQADT------------------ 615
            ...|....:.|....:.:.:.:.:::..|.:|:....|:: |:..||
Yeast   378 TDDDALSYTESIKYSTNETEEEDNEDNESIEDKNEDNESIEDENEDTDSYKFSNREKGSILLTSD 442

  Fly   616 ---KHTGKSQQSQSGQSKTPSNLDLSDMDSAQSAPDLAATNALAAAAAATLQHSDSSNSSFPDLP 677
               :..|.|..|..|..|.|.:...|.|.......|    :||......|:::::.|||.
Yeast   443 EEEEEKGMSSDSDEGSLKAPKSGYFSKMIGNDDKGD----SALQPNQIDTIENTNLSNSG----- 498

  Fly   678 ARSSSQQKPTKGNTGSGKETKSTVKEHKGKSKQNDKTLEKNT--DKTEKPDKTPDPKVDKSEKSE 740
                   ...:.:.||.:|      :|..:    ||.||:::  |.|:.....||.:..:|...:
Yeast   499 -------SELENSDGSDEE------DHINE----DKVLEESSVKDSTDVDSWKPDSEALRSGFVQ 546

  Fly   741 KEDKKRNRRSSQSSNSGSGAGVTGAFIEPPVKASKKEQGK---AAGEKSKSPSLRPPRETNSTGT 802
            ....|:........::|....:|.|.::|.|.::..|...   |...|.:...|...|:|.:...
Yeast   547 DTANKKAPPGYVIDSNGKLVDLTPASMKPRVVSTYSEMESTWDAFPSKGEDDDLETIRDTKTIYD 611

  Fly   803 GGGTPNAGAGFLAPPSSSPSNNHSAAVAASLNNNN----NNNNNNT------------NSNSSHS 851
            .....|. .|.:...|:.|.....|....:..|:|    |:|:|||            :.|.:.|
Yeast   612 NNTIYNV-PGLIGNQSNLPPLPMDAQEQLNAGNDNSTTDNDNSNNTANDLAARSASFKSENRTVS 675

  Fly   852 PGEMTTPGQLQLPTEYLSELQELH-------HKIMTLQDNEELQHV--VEMIAATGCYEITHKTF 907
            .||||:..:..  ||.:::|.:.:       :|::    |.:..|.  :|.:          :.:
Yeast   676 QGEMTSVHEPS--TEEMAKLGQQNNLPKLDMNKLL----NSKTSHAGKIEQL----------RNY 724

  Fly   908 DFDLCKLDRG-----------TVQRLQEFLATSVSXHS 934
            ..:|.:.|.|           :..:.::|:|.....||
Yeast   725 KRELDEYDTGIQTWINYTLKSSSNKDKDFIAEEYKQHS 762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ear	NP_001262595.1	YEATS	27..107	CDD:281374
FYV8	NP_011712.1	MSCRAMM_ClfA	<197..529	CDD:411231	71/359 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000