DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ear and YEATS2

DIOPT Version :9

Sequence 1:	NP_001262595.1	Gene:	ear / 44451	FlyBaseID:	FBgn0026441	Length:	945	Species:	Drosophila melanogaster
Sequence 2:	NP_001338299.1	Gene:	YEATS2 / 55689	HGNCID:	25489	Length:	1423	Species:	Homo sapiens

Alignment Length:	1139	Identity:	226/1139 - (19%)
Similarity:	361/1139 - (31%)	Gaps:	329/1139 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VKVQFEIGHTSKL--RSKKTPHPQAFTHDWEIYVQGVNK-ADISAFVEKVVFVLHESFPKPKRV- 63
            ||....:|:.||.  ..|:..:.|: ||.|.:||:|..: ..|:.||:||.|.||.|: ||..:
Human   206 VKKTIVVGNVSKYIPPDKREENDQS-THKWMVYVRGSRREPSINHFVKKVWFFLHPSY-KPNDLV 268

  Fly    64 -VKEPPYAIQESGYAGFLLPVEIYFRNRDEPKRIVYQYDLVLQSTGPPQHHVEVKTHIFEAPSEE 127
             |:|||:.:...|:..|.:.|:::|:: .:.|||...::|.|..|
Human   269 EVREPPFHLTRRGWGEFPVRVQVHFKD-SQNKRIDIIHNLKLDRT-------------------- 312

  Fly   128 FRTKLMRGGGVPVFGANIGAGSLAR-TLSPSVGSGETAHSNEMSGVKAKGVPGTISMNSDLNTGK 191
             .|.|...|...|....:...||.. .:.|.  |.|:..|:....:... :|..:..:|.:.  :
Human   313 -YTGLQTLGAETVVDVELHRHSLGEDCIYPQ--SSESDISDAPPSLPLT-IPAPVKASSPIK--Q 371

  Fly   192 KHKSRSEDPGKSNAFSALFGPPITKTSV-TANNMAQVPVSKHSPEAKSAAVGGKGVFHEGREKAS 255
            .|:                  |:..||| .|...|.....:|:|            |:.......
Human   372 SHE------------------PVPDTSVEKAGFPASTEAERHTP------------FYALPSSLE 406

  Fly   256 KDRDKSSGGDKPREKDKKDRHGRD-------------KDRKSSKSGDGKHERDKEKSKKDKSRDK 307
            :...|.:    ..:|.....||..             :.:..:....||..:....|.|..|
Human   407 RTPTKMT----TSQKVTFCSHGNSAFQPIASSCKIVPQSQVPNPESPGKSFQPITMSCKIVS--- 464

  Fly   308 EREREQGSGNTT--------SANALTVATSVGTAGGLVKH---TASPKPGK------PNEMGAPS 355
                  ||..:|        :..:..|....||||.::.:   ....:||:      |: .|:|:
Human   465 ------GSPISTPSPSPLPRTPTSTPVHVKQGTAGSVINNPYVIMDKQPGQVIGATTPS-TGSPT 522

  Fly   356 PK-KTANDSAAGAVAP----------TSRSKERD-------------EHKSVKS----------- 385
            .| .||:..:.|..:|          ||..|:.|             .|..|:|
Human   523 NKISTASQVSQGTGSPVPKIHGSSFVTSTVKQEDSLFASMPPLCPIGSHPKVQSPKPITGGLGAF 587

  Fly   386 -----ESKDKERSSSKKSKKDKKDKDKQRDESKDKRMPKDERPGQSDSPASGNLQSAHLQQQSQV 445
                 :.:..|......:....:....|....|...|.......|..:|..|..|||.:|....|
Human   588 TKVIIKQEPGEAPHVPATGAASQSPLPQYVTVKGGHMIAVSPQKQVITPGEGIAQSAKVQPSKVV 652

  Fly   446 -ASTGKATPTSVG------------SNSSSSMVSNIGKQKEEATGKHSEKAAESKG--------- 488
             ...|.|.|::|.            :.:|||:...:|.::....|  ..||..|.|
Human   653 GVPVGSALPSTVKQAVAISGGQILVAKASSSVSKAVGPKQVVTQG--VAKAIVSGGGGTIVAQPV 715

  Fly   489 -------------DKSTSNGN--------ATDTKKSHKHKKKEKSKDKEKERNDRDKDKDKERDK 532
                         .||.|.|:        ||:...........|.......:|...|.|.....:
Human   716 QTLTKAQVTAAGPQKSGSQGSVMATLQLPATNLANLANLPPGTKLYLTTNSKNPSGKGKLLLIPQ 780

  Fly   533 DKLKEREKDKQHVTGSEKSSTVDPSPKLEGASPATEGGAPDKTPVSASASSGSKKEKHKKSKEKS 597
            ..:.....:....:||..|..       .||.....||....:......|:|..........:.:
Human   781 GAILRATNNANLQSGSAASGG-------SGAGGGGGGGGGGGSGSGGGGSTGGGGGTAGGGTQST 838

  Fly   598 SGKDEKRQR----EAVDKQA--DTKHTGKSQQSQSGQSKTPSNLDLSDM----DSAQSAPDLAA- 651
            :|.....|.    ..:.||.  .|...|:.....||:..|..::....:    .|||....|..
Human   839 AGPGGISQHLTYTSYILKQTPQGTFLVGQPSPQTSGKQLTTGSVVQGTLGVSTSSAQGQQTLKVI 903

  Fly   652 --------TNALAAAAAATLQHSDSSNSSFP-----------------------DLPARSSSQQK 685
                    |.|.....|:.::.|||:..:.|                       ..||.:.|...
Human   904 SGQKTTLFTQAAHGGQASLMKISDSTLKTVPATSQLSKPGTTMLRVAGGVITTATSPAVALSANG 968

  Fly   686 PTKGNTGSGKETKSTVKEHKGKSKQNDKTLEK---NTDKTEKPD--------KTPDP-------- 731
            |.:.:.|....:.|||......|.|....:.:   .|.|...|.        .||:|
Human   969 PAQQSEGMAPVSSSTVSSVTKTSGQQQVCVSQATVGTCKAATPTVVSATSLVPTPNPISGKATVS 1033

  Fly   732 ---KVDKSEKSEKEDKKR--NRRSSQSSNSGSGAGVTGAFIEPPVKASKKEQGKAAGEKSKSPSL 791
               |:..|:.|.::....  ::....|.|:..|...    |..||  :|..|..:.   ||.|::
Human  1034 GLLKIHSSQSSPQQAVLTIPSQLKPLSVNTSGGVQT----ILMPV--NKVVQSFST---SKPPAI 1089

  Fly   792 RPPRETNSTGTGGGTPNAGAGFLAPPSSSPSNNHSAAVAASLNNNNNNNNNNTNSNSSHSPGE-- 854
            .|        ....||       ..|||:|     ||||..             .....:||.
Human  1090 LP--------VAAPTP-------VVPSSAP-----AAVAKV-------------KTEPETPGPSC 1121

  Fly   855 MTTPGQLQLPTEYLSELQELHHKIMTLQDNEELQHVV----EMIAA----TGCY--EITHKTFDF 909
            ::..||..:.||..|||.....||..|:..::|...|    .:|.|    ..|:  :...:.:.:
Human  1122 LSQEGQTAVKTEESSELGNYVIKIDHLETIQQLLTAVVKKIPLITAKSEDASCFSAKSVEQYYGW 1186

  Fly   910 DLCKLDRGTVQR-------LQEFLATSVSXHSLT 936
            ::.|......||       |||.|..:...|.||
Human  1187 NIGKRRAAEWQRAMTMRKVLQEILEKNPRFHHLT 1220

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ear	NP_001262595.1	YEATS	27..107	CDD:281374	30/82 (37%)
YEATS2	NP_001338299.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	117..198
		YEATS	231..310	CDD:308783	29/80 (36%)
		Histone H3K27cr binding. /evidence=ECO:0000269\|PubMed:27103431, ECO:0007744\|PDB:5IQL	259..261		1/1 (100%)
		Histone H3K27cr binding. /evidence=ECO:0000269\|PubMed:27103431, ECO:0007744\|PDB:5IQL	282..284		0/1 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	466..487		3/20 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	514..541		8/27 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	795..843		10/54 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5033
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1482359at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820