DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ear and mllt3

DIOPT Version :9

Sequence 1:	NP_001262595.1	Gene:	ear / 44451	FlyBaseID:	FBgn0026441	Length:	945	Species:	Drosophila melanogaster
Sequence 2:	XP_012818507.1	Gene:	mllt3 / 549668	XenbaseID:	XB-GENE-6257679	Length:	578	Species:	Xenopus tropicalis

Alignment Length:	952	Identity:	223/952 - (23%)
Similarity:	330/952 - (34%)	Gaps:	403/952 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 AVKVQFEIGHTSKLRSKKTPHPQAFTHDWEIYVQGVNKADISAFVEKVVFVLHESFPKPKRVVKE 66
            ||:|:.|:||.:::|.|  |..:.|||||.::|:|...::|..|||||||.||||||:||||.|:
Frog     3 AVQVKLELGHRAQVRKK--PTLEGFTHDWMVFVRGPEHSNIQHFVEKVVFHLHESFPRPKRVCKD 65

  Fly    67 PPYAIQESGYAGFLLPVEIYFRNRDEPKRIVYQYDLVLQSTG-PPQHHVEVKTHIFEAPSEEFRT 130
            |||.::|||||||:||:|:||:|::|||::.:.|||.|...| ||.:|:..:...|..|:||||.
Frog    66 PPYKVEESGYAGFILPIEVYFKNKEEPKKVRFDYDLFLHLEGHPPVNHLRCEKLTFNNPTEEFRR 130

  Fly   131 KLMRGGGVPVFGANIGAGSLARTLSPSVGSGETAHSNEMSGVKAKGVPGTISMNSDLNTGKKHKS 195
            ||::.||:.|    ...||       |..||.:.|           :|.....:...:..||.||
Frog   131 KLLKAGGIMV----TSEGS-------SFSSGTSLH-----------LPSLPCNSLSFSDVKKSKS 173

  Fly   196 R--SEDPGKSNAFSALFGPPITKTSVTANNMA-QVPVSKHSPEAKSAAVGGKGVFHEGREKASKD 257
            .  |:||.|               .|:.||.: .:.:||....:|           |.:||:||
Frog   174 SHGSKDPNK---------------LVSINNSSNSISLSKPHKSSK-----------EHKEKSSK- 211

  Fly   258 RDKSSGGDKPREKDKKDRHGRDKDRKSSKSGDGKHERDKEKSKKDKSRDKEREREQGSGNTTSAN 322
                                                    .||:.:|..||..||....:..|:.
Frog   212 ----------------------------------------YSKEHRSAFKEPSREHNKSSKESSK 236

  Fly   323 ALTVATSVGTAGGLVKHTASPKPGKPNEMGAPSPKKTANDSAAGAVAPTSRSKE-RDEHKSVKSE 386
                               .||..||.:.....||....:       |...||| |.|:.::.:.
Frog   237 -------------------KPKENKPLKEEKIVPKMAFKE-------PKPMSKEPRCENNNILTV 275

  Fly   387 SKDKERSSSKKSKKDKKDKDKQRDESKDKRMPKDERPGQSDSPASGNLQSAHLQQQSQVASTGKA 451
            |...::.....||                      ||             .||..:...|...|.
Frog   276 STGHQQEKKLSSK----------------------RP-------------PHLDSEDPFARKRKK 305

  Fly   452 TPTSVGSNSSSSMVSNIGKQKEEATGKHSEKAAESKGDKSTSNGNATDTKKSHKHKKKEKSKDKE 516
                  |||.||:                         ||.||.:......|.|...::||..|
Frog   306 ------SNSESSV-------------------------KSFSNSSLLILSSSDKKPLRDKSVHK- 338

  Fly   517 KERNDRDKDKDKERDKDKLKEREKDKQHVTGSEKSSTVDP--SPKLEGASPATEGGAPDKTPVSA 579
                         ..|.|::....||:.::.......|||  :...:..|..:|.|.|  :|.|:
Frog   339 -------------IGKVKIESEVMDKKKLSLPPFEDIVDPNDTDMEDNMSSKSESGQP--SPASS 388

  Fly   580 SASSGSK----KEKHKKS-------------KEKSSGKDEKRQREAVDKQADTKHTGKSQQSQSG 627
            |:||.|.    ...|::.             |:..|..:|....:|.|..::    |:......|
Frog   389 SSSSSSSLAPPPHNHRQGFFVSCPGSLRSIVKDLHSDDNEDESDDAEDNDSE----GERTIYMHG 449

  Fly   628 QSKTPSNLDLSDMDSAQSAPDLAATNALAAAAAATLQHSDSSNSSFPDLPARSSSQQKPTKGNTG 692
            .|:                             |..:..||.|||       .|||...|.:
Frog   450 GSR-----------------------------ARRISLSDGSNS-------ESSSVSSPLR---- 474

  Fly   693 SGKETKSTVKEHKGKSKQNDKTLEKNTDKTEKPDKTPDPKVDKSEKSEKEDKKRNRRSSQSSNSG 757
              .|..:.:|.:      |::.||
Frog   475 --NEPPTLLKTN------NNQILE----------------------------------------- 490

  Fly   758 SGAGVTGAFIEPPVKASKKEQGKAAGEKSKSPSLRPPRETNSTGTGGGTPNAGAGFLAPPSSSPS 822
                     ::.|:|.||.|:....|:..|:
Frog   491 ---------VKSPIKQSKSEKQIKNGDCDKA---------------------------------- 512

  Fly   823 NNHSAAVAASLNNNNNNNNNNTNSNSSHSPGEMTTPGQLQLPTEYLSELQELHHKIMTLQDNEEL 887
                                                        ||.||.|||.::|||::...|
Frog   513 --------------------------------------------YLDELVELHRRLMTLRERHVL 533

  Fly   888 QHVVEMIAATGCYEITHKTFDFDLCKLDRGTVQRLQEFLATS 929
            |.:|.:|..||.:.||:.|||||||.||:.||::||.:|.|:
Frog   534 QQIVNLIEETGHFHITNTTFDFDLCSLDKTTVRKLQSYLETT 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ear	NP_001262595.1	YEATS	27..107	CDD:281374	48/79 (61%)
mllt3	XP_012818507.1	YEATS_AF-9_like	6..134	CDD:341125	68/129 (53%)
mllt3	XP_012818507.1	AHD	513..573	CDD:375335	31/59 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	118	1.000	Domainoid score	I5784
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	185	1.000	Inparanoid score	I3812
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003550
OrthoInspector	1	1.000	-	-		otm49384
Panther	1	1.100	-	-	LDO	PTHR23195
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2426
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.060