DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ear and MLLT3

DIOPT Version :9

Sequence 1:NP_001262595.1 Gene:ear / 44451 FlyBaseID:FBgn0026441 Length:945 Species:Drosophila melanogaster
Sequence 2:NP_004520.2 Gene:MLLT3 / 4300 HGNCID:7136 Length:568 Species:Homo sapiens


Alignment Length:933 Identity:214/933 - (22%)
Similarity:322/933 - (34%) Gaps:378/933 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 AVKVQFEIGHTSKLRSKKTPHPQAFTHDWEIYVQGVNKADISAFVEKVVFVLHESFPKPKRVVKE 66
            ||:|:.|:||.:::|.|  |..:.|||||.::|:|...::|..|||||||.||||||:||||.|:
Human     6 AVQVKLELGHRAQVRKK--PTVEGFTHDWMVFVRGPEHSNIQHFVEKVVFHLHESFPRPKRVCKD 68

  Fly    67 PPYAIQESGYAGFLLPVEIYFRNRDEPKRIVYQYDLVLQSTG-PPQHHVEVKTHIFEAPSEEFRT 130
            |||.::|||||||:||:|:||:|::||:::.:.|||.|...| ||.:|:..:...|..|:|:||.
Human    69 PPYKVEESGYAGFILPIEVYFKNKEEPRKVRFDYDLFLHLEGHPPVNHLRCEKLTFNNPTEDFRR 133

  Fly   131 KLMRGGGVPVFGANIGAGSLARTLSPSVGSGETAHSNEMSGVKAKGVPGTISMNSDLNTGKKHKS 195
            ||::.||.|           .|::..|..|..::.|:..|         :.|.:|..::.....|
Human   134 KLLKAGGDP-----------NRSIHTSSSSSSSSSSSSSS---------SSSSSSSSSSSSSSSS 178

  Fly   196 RSEDPGKSNAFSALFGPPITKTSVTANNMAQVPVSKHSPEAKSAAVGGKGVFHEGREKASKDRDK 260
            .|.....|::.|..|..|                  |.            :..|.:||.|||   
Human   179 SSSSSSSSSSSSTSFSKP------------------HK------------LMKEHKEKPSKD--- 210

  Fly   261 SSGGDKPREKDKKDRHGRDKDRKSSKSGDGKHERDKEKSKKDKSRDKEREREQGSGNTTSANALT 325
                                                                             
Human   211 ----------------------------------------------------------------- 210

  Fly   326 VATSVGTAGGLVKHTASPKPGKPNEMGAPSPKKTANDSAAGAVAPTSRSKERDEHKSV-KSESKD 389
                                                          ||     ||||. |..|:|
Human   211 ----------------------------------------------SR-----EHKSAFKEPSRD 224

  Fly   390 KERSSSKKSKKDKKDKDKQRDESKDKRMPKDERPGQSDSPASGNLQSAHLQQQSQVASTGKATPT 454
            ..:||.:.|||.|::|..:.::...|...|:.:|...:.....||.:....|..:..|  |..|.
Human   225 HNKSSKESSKKPKENKPLKEEKIVPKMAFKEPKPMSKEPKPDSNLLTITSGQDKKAPS--KRPPI 287

  Fly   455 SVGSNSSSSMVSNIGKQKEEATGKHSEKAAESKGDKSTSNGNATDTKKSHKHKKKEKSKDKEKER 519
            |               ..||.:.|..:|::.....||.|:........|                
Human   288 S---------------DSEELSAKKRKKSSSEALFKSFSSAPPLILTCS---------------- 321

  Fly   520 NDRDKDKDKERDKDKLKEREKDKQHVTGSEKSSTVDPSPKLEGASPATEGGAPDKTPVSASASSG 584
                .||.:.:||..:|..:...:..|..:|.||:.|...:..         |:.:.|..:.||.
Human   322 ----ADKKQIKDKSHVKMGKVKIESETSEKKKSTLPPFDDIVD---------PNDSDVEENISSK 373

  Fly   585 SKKEKHKKSKEKSSGKDEKRQREAVDKQADTKHTGKSQQSQSGQSKTPSNLDLSDMDSAQSAPDL 649
            |                                                       ||.|.:|  
Human   374 S-------------------------------------------------------DSEQPSP-- 381

  Fly   650 AATNALAAAAAATLQHSDSSNSSFPDLPARSSSQQKPTKGNTGSGKETKSTVKE-HKGKSKQNDK 713
                         ...|.||:|||.....|   ||.|          .:|.:|: |...:::...
Human   382 -------------ASSSSSSSSSFTPSQTR---QQGP----------LRSIMKDLHSDDNEEESD 420

  Fly   714 TLEKNTDKTEKPDKTPDPKVDKSEKSEKEDKKRNRRSSQS--SNSGSGAGVTGAFIEPPVKASKK 776
            .:|.|.:.:|            .|:.......|:||.|.|  |:|.|.:..:....|||      
Human   421 EVEDNDNDSE------------MERPVNRGGSRSRRVSLSDGSDSESSSASSPLHHEPP------ 467

  Fly   777 EQGKAAGEKSKSPSLRPPRETNSTGTGGGTPNAGAGFLAPPSSSPSNNHSAAVAASLNNNNNNNN 841
                                                   ||....:||....|.:.:        
Human   468 ---------------------------------------PPLLKTNNNQILEVKSPI-------- 485

  Fly   842 NNTNSNSSHSPGEMTTPGQLQLPTEYLSELQELHHKIMTLQDNEELQHVVEMIAATGCYEITHKT 906
            ..:.|:.....||        ....||.||.|||.::|||::...||.:|.:|..||.:.||:.|
Human   486 KQSKSDKQIKNGE--------CDKAYLDELVELHRRLMTLRERHILQQIVNLIEETGHFHITNTT 542

  Fly   907 FDFDLCKLDRGTVQRLQEFLATS 929
            ||||||.||:.||::||.:|.||
Human   543 FDFDLCSLDKTTVRKLQSYLETS 565

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
earNP_001262595.1 YEATS 27..107 CDD:281374 47/79 (59%)
MLLT3NP_004520.2 YEATS_AF-9_like 9..137 CDD:341125 66/129 (51%)
Inhibitor XL-07i binding. /evidence=ECO:0000269|PubMed:30374167, ECO:0007744|PDB:5YYF 56..58 1/1 (100%)
Histone H3K9cr binding. /evidence=ECO:0000269|PubMed:27105114, ECO:0000269|PubMed:30385749, ECO:0007744|PDB:5HJB, ECO:0007744|PDB:5HJD, ECO:0007744|PDB:6MIL, ECO:0007744|PDB:6MIM 78..80 1/1 (100%)
Inhibitor XL-07i binding. /evidence=ECO:0000269|PubMed:30374167, ECO:0007744|PDB:5YYF 106..109 1/2 (50%)
Histone H3K9cr binding. /evidence=ECO:0000269|PubMed:27105114, ECO:0000269|PubMed:30385749, ECO:0007744|PDB:5HJB, ECO:0007744|PDB:5HJD, ECO:0007744|PDB:6MIL, ECO:0007744|PDB:6MIM 106..108 1/1 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 137..475 106/692 (15%)
Nuclear localization signal. /evidence=ECO:0000255 295..300 1/4 (25%)
AHD 503..563 CDD:375335 31/59 (53%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165152546
Domainoid 1 1.000 117 1.000 Domainoid score I5919
eggNOG 1 0.900 - - E1_COG5033
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 188 1.000 Inparanoid score I3921
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0003550
OrthoInspector 1 1.000 - - otm42157
orthoMCL 1 0.900 - - OOG6_108782
Panther 1 1.100 - - LDO PTHR23195
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X2426
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1110.750

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