Protein Alignment ear and MLLT1

DIOPT Version :9

• Sequence 1: NP_001262595.1
• Gene: ear / 44451
• FlyBaseID: FBgn0026441
• Length: 945
• Species: Drosophila melanogaster
• Sequence 2: XP_011526323.1
• Gene: MLLT1 / 4298
• HGNCID: 7134
• Length: 600
• Species: Homo sapiens
• Alignment Length: 926
• Identity: 226/926 - (24%)
• Similarity: 326/926 - (35%)
• Gaps: 380/926 - (41%)

  Fly     3 VKVQFEIGHTSKLRSKKTPHPQAFTHDWEIYVQGVNKADISAFVEKVVFVLHESFPKPKRVVKEP 67
            |:|:.|:||.::||.|  |..:.|||||.::|:|..:.||..|||||||.||:|||||:||.|||
Human    48 VQVRLELGHRAQLRKK--PTTEGFTHDWMVFVRGPEQCDIQHFVEKVVFWLHDSFPKPRRVCKEP 110

  Fly    68 PYAIQESGYAGFLLPVEIYFRNRDEPKRIVYQYDLVLQSTG-PPQHHVEVKTHIFEAPSEEFRTK 131
            ||.::|||||||::|:|::|:|::||:::.:.|||.|...| ||.:|:..:...|..|:.|||.|
Human   111 PYKVEESGYAGFIMPIEVHFKNKEEPRKVCFTYDLFLNLEGNPPVNHLRCEKLTFNNPTTEFRYK 175

  Fly   132 LMRGGGVPVFGANIGAGSLARTLSPSVGSGETAHSNEMSGVKAKGVPGTISMNSDLNTGKKHKSR 196
            |:|.|||.|...  ||.:::|. ||..
Human   176 LLRAGGVMVMPE--GADTVSRP-SPDY-------------------------------------- 199

  Fly   197 SEDPGKSNAFSALFGPPITKTSVTANNMAQVPVSKHSPEAKSAAVGGKGVFHEGREKASKDRDK- 260
                            |:..|         :|:|..|...|:....|           |||.:|
Human   200 ----------------PMLPT---------IPLSAFSDPKKTKPSHG-----------SKDANKE 228

  Fly   261 SSGGDKPREKDKKDRHGRDKDRKSSKSGDGKHERDKEKSKKDKSRDKEREREQGSGNTTSANALT 325
            ||...||.:..|:.|....|| ..|||...:.||::.||.||.|      |:.|.|..
Human   229 SSKTSKPHKVTKEHRERPRKD-SESKSSSKELEREQAKSSKDTS------RKLGEGRL------- 279

  Fly   326 VATSVGTAGGLVKHTASPKPGKPNEMGAPSPKKTANDSAAGAVAPTSRSKERDEHKSVKSESKDK 390
                                  |.|..||.||       |....|....||            .|
Human   280 ----------------------PKEEKAPPPK-------AAFKEPKMALKE------------TK 303

  Fly   391 ERSSSKKSKKDKKDKDKQRDESKDKRMPKDERPGQSDSPASGNLQSAHLQQQSQVASTGKATPTS 455
            ..|:|.|...........|..||        ||..:|||
Human   304 LESTSPKGGPPPPPPPPPRASSK--------RPATADSP-------------------------- 334

  Fly   456 VGSNSSSSMVSNIGKQKEEATGKHSEKAAESKGDKSTSNGNATDTKKSHKHKKKEKSKDKEKERN 520
                                                         |.|.|.:||..||
Human   335 ---------------------------------------------KPSAKKQKKSSSK------- 347

  Fly   521 DRDKDKDKERDKDKLKEREKDKQHVTGSEKSSTVDPSPKLEGASPATEGGAPDKTPVSASASSGS 585
                                      ||.                    .||..:|.::|:||.|
Human   348 --------------------------GSR--------------------SAPGTSPRTSSSSSFS 366

  Fly   586 KKEKHKKSKEKSSGKDEKRQREAVDKQADTKHTGKSQQSQSGQSKTPSNLDLSDMDSAQSAPDLA 650
            .|   |.:|:|||.:.||.:.|:..::|.     |:.:.:...|:..::.   ..:||||:|..:
Human   367 DK---KPAKDKSSTRGEKVKAESEPREAK-----KALEVEESNSEDEASF---KSESAQSSPSNS 420

  Fly   651 ATNALAAAAAATLQHSDSSNSSFPDLPARSSSQQKPTKGNTGSGKETKSTVKEHKGKSKQNDKTL 715
            :::            ||||:.|  |.....:..|.|          .:|.|::.
Human   421 SSS------------SDSSSDS--DFEPSQNHSQGP----------LRSMVEDL----------- 450

  Fly   716 EKNTDKTEKPDKTPDPKVDKSEKSEKEDKKRNRRSSQSSNSGSGAGVTGAFIEPPVKASKKEQGK 780
                               :||:|:::|         ||:....||.|....:..:..|..|...
Human   451 -------------------QSEESDEDD---------SSSGEEAAGKTNPGRDSRLSFSDSESDN 487

  Fly   781 AAGEKSKSPSLRPPRETNSTGTGGGTPNAGAGFLAPPSSSPSNNHSAAVAASLNNNNNNNNNNTN 845
            :|  .|..||..||                     ||...|..|...             :...:
Human   488 SA--DSSLPSREPP---------------------PPQKPPPPNSKV-------------SGRRS 516

  Fly   846 SNSSHSPGEMTTPGQLQLPTEYLSELQELHHKIMTLQDNEELQHVVEMIAATGCYEITHKTFDFD 910
            ..|...|.::...|...  ..|..||.|||.::|.|::...||.:|.:|..||.:.:|:.|||||
Human   517 PESCSKPEKILKKGTYD--KAYTDELVELHRRLMALRERNVLQQIVNLIEETGHFNVTNTTFDFD 579

  Fly   911 LCKLDRGTVQRLQEFL 926
            |..||..||::||..|
Human   580 LFSLDETTVRKLQSCL 595

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ear	NP_001262595.1	YEATS	27..107	CDD:281374	46/79 (58%)
MLLT1	XP_011526323.1	YEATS	70..150	CDD:281374	46/79 (58%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152547
Domainoid	1	1.000	117	1.000	Domainoid score	I5919
eggNOG	1	0.900	-	-		E1_COG5033
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	188	1.000	Inparanoid score	I3921
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003550
OrthoInspector	1	1.000	-	-		otm42157
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23195
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5409
SonicParanoid	1	1.000	-	-		X2426
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.880