DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ear and Yeats2

DIOPT Version :9

Sequence 1:	NP_001262595.1	Gene:	ear / 44451	FlyBaseID:	FBgn0026441	Length:	945	Species:	Drosophila melanogaster
Sequence 2:	NP_001139402.1	Gene:	Yeats2 / 208146	MGIID:	2447762	Length:	1407	Species:	Mus musculus

Alignment Length:	973	Identity:	198/973 - (20%)
Similarity:	300/973 - (30%)	Gaps:	366/973 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VKVQFEIGHTSKL--RSKKTPHPQAFTHDWEIYVQGVNK-ADISAFVEKVVFVLHESFPKPKRV- 63
            ||....:|:.||.  ..|:..:.|: ||.|.:||:|..: ..|:.||:||.|.||.|: ||..:
Mouse   207 VKKTIVVGNVSKYIPPDKREENDQS-THKWMVYVRGSRREPSINHFVKKVWFFLHPSY-KPNDLV 269

  Fly    64 -VKEPPYAIQESGYAGFLLPVEIYFRNRDEPKRIVYQYDLVLQSTGPPQHHVEVKTHIFEAPSEE 127
             |:|||:.:...|:..|.:.|:::|:: .:.|||...::|.|..|..
Mouse   270 EVREPPFHLTRRGWGEFPVRVQVHFKD-SQNKRIDIIHNLKLDRTYT------------------ 315

  Fly   128 FRTKLMRGGGVPVFGANIGAGSLARTLSPSVGSGETAHSNEMSGVKAKGVPGTISMNSDLNTGKK 192
                     |:...||                  ||....|:                     .:
Mouse   316 ---------GLQTLGA------------------ETVVDVEL---------------------HR 332

  Fly   193 HKSRSEDP--GKSNAFSALFGPPITKT---SVTANNMAQVPVSKHSPEAKSAAVGGKGVFHEGRE 252
            | |..||.  .:|:.......||.|.|   :|.|:.:||      |||..:||..|:| |.|..|
Mouse   333 H-SLGEDSVYPQSSESDVCDAPPPTLTLPAAVKASAVAQ------SPEPAAAAPVGEG-FPETTE 389

  Fly   253 KASKDRDKSSGGDKPREKDKKDRHGRDKDRKSSKSGDGKHERDKEKSKKDKSRDKEREREQGSGN 317
                                .:||.......||.      ||...|
Mouse   390 --------------------AERHSTFYSLPSSL------ERTPTK------------------- 409

  Fly   318 TTSANALTVAT-------SVGTAGGLVKHTASPKPGKPNEMGAP----------SPKKTANDSAA 365
            .|:|..:|.::       .:.::..:|..:..|.|..|.:...|          ||..|.:.|
Mouse   410 VTTAQKVTFSSHGNSAFQPIASSCKIVPQSQVPNPESPGKSFQPITMSCKIVSGSPISTPSPS-- 472

  Fly   366 GAVAPTSRSKERDEHKSVKSESKDKERSSSKKSKKDKKDKDKQRDESKDKRMPKDERPGQ---SD 427
                |..|:.     .|.....|....||...:.....||                 |||   :.
Mouse   473 ----PLPRTP-----TSTPVHLKQGTASSGVSNPHVIVDK-----------------PGQVIGAS 511

  Fly   428 SPASGNLQSAHLQQQSQVA-STGKATPTSVGSNSSSSMVSNIGKQKEE---------ATGKHSEK 482
            :|::|: .::.|...||.: .||...|...||:..:|.|    ||:|.         ..|.|
Mouse   512 TPSTGS-PTSKLPVASQASQGTGSPIPKIHGSSFLTSTV----KQEESLFASMPPLCPIGSH--- 568

  Fly   483 AAESKGDKSTSNGNATDTKKSHKHKKKEKSKDKEKERNDRDKDKDKERDKDKLKEREKDKQHV-- 545
             .:.:..|:.:.|....||..                               :|:...:..||
Mouse   569 -PKVQSPKAVTGGLGAFTKVI-------------------------------IKQEPGEAPHVST 601

  Fly   546 TGSEKSS--------------TVDPSPKLEGASPATEGG---APDK---TPVSASASSGSKKEKH 590
            ||:...|              .|.|..::..|...|...   ||.|   .||.::..|..|:...
Mouse   602 TGAASQSAFPQYVTVKGGHMIAVSPQKQVISAGEGTTQSPKIAPSKVVGVPVGSALPSTVKQAVA 666

  Fly   591 KKSKEKSSGKDEKRQREAV-DKQADTKHTGKSQQSQSGQSKTPSNLDLSDMDSAQSAPDLAATNA 654
            ..|.:....|......:|| .||..|:...|:..|..|.:..           ||....|..|..
Mouse   667 ISSGQILVAKASSSVTKAVGPKQVVTQGVAKAIVSGGGGTIV-----------AQPVQTLTKTQV 720

  Fly   655 LAA---------AAAATLQHSDSSNSSFPDLPARSSSQQKPTKGNTGSGKETKSTVKEHKGKSKQ 710
            .||         :..||||...::.::..:||. .:.....|.....|||.....:.:.......
Mouse   721 TAAGPQKSGSQGSVMATLQLPATNLANLANLPP-GTKLYLTTNSKNPSGKGKLLLIPQGAILRAT 784

  Fly   711 NDKTLEKNTDKTEKPDKTPDPKVDKSEKSEKEDKKRNRRSSQSSNSGSGAGVTGAFIEPPVKASK 775
            |:..|:..:...                          ..|.||.:|.|:|..|
Mouse   785 NNANLQSGSAAA--------------------------GGSGSSGAGGGSGGGG----------- 812

  Fly   776 KEQGKAAGEKSKSPSLRPPRETNSTGTGGG-------------TPNAGAGFLAPPSSSPSNNHSA 827
               |..||   .:||        ::|.|||             ||. |...:..|  ||......
Mouse   813 ---GSGAG---GTPS--------TSGPGGGPQHLTYTSYILKQTPQ-GTFLVGQP--SPQTPGKQ 860

  Fly   828 AVAASLNNNNNNNNNNTNSNSSHSPGEMT----------------TPGQ---LQLPTEYLSEL 871
            ...||:      .......:||.:.|:.|                |.||   |:||...|..:
Mouse   861 LTTASV------VQGTLGVSSSSAQGQQTLKVISGQKTTLFTQAATAGQASLLKLPDNTLKSV 917

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ear	NP_001262595.1	YEATS	27..107	CDD:281374	30/82 (37%)
Yeats2	NP_001139402.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	116..196
		YEATS_YEATS2_like	209..332	CDD:341126	42/191 (22%)
		Histone H3K27cr binding. /evidence=ECO:0000250\|UniProtKB:Q9ULM3	260..262		1/1 (100%)
		Histone H3K27cr binding. /evidence=ECO:0000250\|UniProtKB:Q9ULM3	283..285		0/1 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	462..540		23/106 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	791..833		16/92 (17%)
		PRK07003	<887..>1123	CDD:235906	7/31 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5033
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1482359at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820