Protein Alignment ear and Mllt3

DIOPT Version :10

• Sequence 1: NP_001262595.1
• Gene: ear / 44451
• FlyBaseID: FBgn0026441
• Length: 945
• Species: Drosophila melanogaster
• Sequence 2: NP_446170.2
• Gene: Mllt3 / 114510
• RGDID: 620940
• Length: 569
• Species: Rattus norvegicus
• Alignment Length: 933
• Identity: 217/933 - (23%)
• Similarity: 323/933 - (34%)
• Gaps: 377/933 - (40%)

  Fly     2 AVKVQFEIGHTSKLRSKKTPHPQAFTHDWEIYVQGVNKADISAFVEKVVFVLHESFPKPKRVVKE 66
            ||:|:.|:||.:::|.|  |..:.|||||.::|:|...::|..|||||||.||||||:||||.|:
  Rat     6 AVQVKLELGHRAQVRKK--PTVEGFTHDWMVFVRGPEHSNIQHFVEKVVFHLHESFPRPKRVCKD 68

  Fly    67 PPYAIQESGYAGFLLPVEIYFRNRDEPKRIVYQYDLVLQSTG-PPQHHVEVKTHIFEAPSEEFRT 130
            |||.::|||||||:||:|:||:|::|||::.:.|||.|...| ||.:|:..:...|..|:|:||.
  Rat    69 PPYKVEESGYAGFILPIEVYFKNKEEPKKVRFDYDLFLHLEGHPPVNHLRCEKLTFNNPTEDFRR 133

  Fly   131 KLMRGGGVPVFGANIGAGSLARTLSPSVGSGETAHSNEMSGVKAKGVPGTISMNSDLNTGKKHKS 195
            ||::.||.|           .|::..|..|..::.|:..|         :.|.:|..::.....|
  Rat   134 KLLKAGGDP-----------NRSIHTSSSSSSSSSSSSSS---------SSSSSSSSSSSSSSSS 178

  Fly   196 RSEDPGKSNAFSALFGPPITKTSVTANNMAQVPVSKHSPEAKSAAVGGKGVFHEGREKASKDRDK 260
            .|.....|::.|..|..|                  |.            :..|.:||.|||
  Rat   179 SSSSSSSSSSSSTSFSKP------------------HK------------LMKEHKEKPSKD--- 210

  Fly   261 SSGGDKPREKDKKDRHGRDKDRKSSKSGDGKHERDKEKSKKDKSRDKEREREQGSGNTTSANALT 325
                                                                             
  Rat   211 ----------------------------------------------------------------- 210

  Fly   326 VATSVGTAGGLVKHTASPKPGKPNEMGAPSPKKTANDSAAGAVAPTSRSKERDEHKSV-KSESKD 389
                                                          ||     ||||. |..|:|
  Rat   211 ----------------------------------------------SR-----EHKSAFKEPSRD 224

  Fly   390 KERSSSKKSKKDKKDKDKQRDESKDKRMPKDERPGQSDSPASGNLQSAHLQQQSQVASTGKATPT 454
            ..:||...|||.|::|..:.::...|...|:.:|...:..|..||.:....||.:.|.: |..|.
  Rat   225 HNKSSKDSSKKPKENKPLKEEKIVPKMAFKEPKPMSKEPKADSNLLTVTSAQQDKKAPS-KRPPV 288

  Fly   455 SVGSNSSSSMVSNIGKQKEEATGKHSEKAAESKGDKSTSNGNATDTKKSHKHKKKEKSKDKEKER 519
            |               ..||.:.|..:|::.....||.|:........|
  Rat   289 S---------------DSEELSAKKRKKSSSEALFKSFSSAPPLILTCS---------------- 322

  Fly   520 NDRDKDKDKERDKDKLKEREKDKQHVTGSEKSSTVDPSPKLEGASPATEGGAPDKTPVSASASSG 584
                .||.:.:||..:|..:...:..|..:|.||:.|...:..         |:.:.|..:.||.
  Rat   323 ----ADKKQIKDKSHVKMGKVKIESETSEKKKSTLPPFDDIVD---------PNDSDVEENMSSK 374

  Fly   585 SKKEKHKKSKEKSSGKDEKRQREAVDKQADTKHTGKSQQSQSGQSKTPSNLDLSDMDSAQSAPDL 649
            |                                                       ||.|.:|
  Rat   375 S-------------------------------------------------------DSEQPSP-- 382

  Fly   650 AATNALAAAAAATLQHSDSSNSSFPDLPARSSSQQKPTKGNTGSGKETKSTVKE-HKGKSKQNDK 713
                         ...|.||:|||.....|   ||.|          .:|.:|: |...:::...
  Rat   383 -------------ASSSSSSSSSFTPSQTR---QQGP----------LRSIMKDLHSDDNEEESD 421

  Fly   714 TLEKNTDKTEKPDKTPDPKVDKSEKSEKEDKKRNRRSSQS--SNSGSGAGVTGAFIEPPVKASKK 776
            ..|.|.:.:|            .|:.......|:||.|.|  |:|.|.:..:....|||
  Rat   422 EAEDNDNDSE------------MERPVNRGGSRSRRVSLSDGSDSESSSASSPLHHEPP------ 468

  Fly   777 EQGKAAGEKSKSPSLRPPRETNSTGTGGGTPNAGAGFLAPPSSSPSNNHSAAVAASLNNNNNNNN 841
                                                   ||....:||....|.:.:
  Rat   469 ---------------------------------------PPLLKTNNNQILEVKSPI-------- 486

  Fly   842 NNTNSNSSHSPGEMTTPGQLQLPTEYLSELQELHHKIMTLQDNEELQHVVEMIAATGCYEITHKT 906
            ..:.|:.....||        ....||.||.|||.::|||::...||.:|.:|..||.:.||:.|
  Rat   487 KQSKSDKQIKNGE--------CDKAYLDELVELHRRLMTLRERHILQQIVNLIEETGHFHITNTT 543

  Fly   907 FDFDLCKLDRGTVQRLQEFLATS 929
            ||||||.||:.||::||.:|.||
  Rat   544 FDFDLCSLDKTTVRKLQSYLETS 566

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ear	NP_001262595.1	YEATS_AF-9_like	5..134	CDD:341125	67/129 (52%)
		AHD	867..927	CDD:436050	31/59 (53%)
Mllt3	NP_446170.2	YEATS_AF-9_like	9..137	CDD:341125	67/129 (52%)
		AHD	504..564	CDD:436050	31/59 (53%)