DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment scrib and degQ

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	NP_417701.1	Gene:	degQ / 947812	ECOCYCID:	G7682	Length:	455	Species:	Escherichia coli

Alignment Length:	591	Identity:	104/591 - (17%)
Similarity:	178/591 - (30%)	Gaps:	244/591 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   844 VADAPPAASISH--ERYIPAPIEI-----VPQQQHLQQQQQQPIQQVAPTHSYSGNVFATPTAAQ 901
            |||..|..|::.  |:.:||.:.:     ..|.|.:.::.::              .|......|
E. coli    33 VADQAPLPSLAPMLEKVLPAVVSVRVEGTASQGQKIPEEFKK--------------FFGDDLPDQ 83

  Fly   902 TVQPAVSAAPNGLLLNGREAPLSYIQLHTTLIRDQIGQGLGFSIAGGK-------GSPPFKDDCD 959
            ..|| .....:|:::|   |...|:..:..:|..  .|.:...:..|:       ||    ||..
E. coli    84 PAQP-FEGLGSGVIIN---ASKGYVLTNNHVINQ--AQKISIQLNDGREFDAKLIGS----DDQS 138

  Fly   960 GIFI------SRITEGGLAYRDGKIMVGDRVMAINGNDMTEAHHDAAVACLTEPQRFVRLVLQRE 1018
            .|.:      |::|:..:|..| |:.|||..:|: ||..
E. coli   139 DIALLQIQNPSKLTQIAIADSD-KLRVGDFAVAV-GNPF-------------------------- 175

  Fly  1019 YRGPLEPPTSPRSPAVLNSLSPSGYLANRPANFSRSVVEVEQPYKYNTLATTTPTPKPTVPASIS 1083
              |..:..||    .::::|..||.......||.::                        .|||:
E. coli   176 --GLGQTATS----GIVSALGRSGLNLEGLENFIQT------------------------DASIN 210

  Fly  1084 NNNNTLPSSKTNGFATAAAATIDSSTGQPVPAPRRTNSVPMGDGDIGAGSTTSGDSGEAQPSSLR 1148
            ..|:.......||      ..|..:|.  :.||        |.|.:|.|.
E. coli   211 RGNSGGALLNLNG------ELIGINTA--ILAP--------GGGSVGIGF--------------- 244

  Fly  1149 PLTSDDFQAMIPAHFLSGGSQHQVHVARPNEVGVSAVTVNVNKPQPDLPMFPAAPTELGRVTETI 1213
                                                                |.|:.:.|.
E. coli   245 ----------------------------------------------------AIPSNMART---- 253

  Fly  1214 TKSTFTETVMTRITDNQLAEPLISEEVVLPKNQGSLGFSIIGGTDHS---CVPFGTR-EPGIFIS 1274
                             ||:.||....:   .:|.||   |.||:.|   ...|... :.|.|:|
E. coli   254 -----------------LAQQLIDFGEI---KRGLLG---IKGTEMSADIAKAFNLDVQRGAFVS 295

  Fly  1275 HIVPGGIASKCGKLRMGDRILKVNEADVSKATHQDAVLELLKPGDEIKLTIQHDPLP-------- 1331
            .::||..::|.| ::.||.|..:|...::......:.:...:||.::||.:..:..|
E. coli   296 EVLPGSGSAKAG-VKAGDIITSLNGKPLNSFAELRSRIATTEPGTKVKLGLLRNGKPLEVEVTLD 359

  Fly  1332 -------------PGFQEVLLSKAE------GERLGMHIKGGLNGQRGNPADPSDEGVFVSKINS 1377
                         |..:...||..:      |.::...:||....|.|...|....||...::||
E. coli   360 TSTSSSASAEMITPALEGATLSDGQLKDGGKGIKIDEVVKGSPAAQAGLQKDDVIIGVNRDRVNS 424

  Fly  1378 VGAARR 1383
            :...|:
E. coli   425 IAEMRK 430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064
		leucine-rich repeat	18..38	CDD:275380
		LRR_8	37..95	CDD:290566
		leucine-rich repeat	39..61	CDD:275380
		leucine-rich repeat	62..84	CDD:275380
		LRR_8	84..138	CDD:290566
		leucine-rich repeat	85..107	CDD:275380
		leucine-rich repeat	108..130	CDD:275380
		LRR_8	129..187	CDD:290566
		leucine-rich repeat	131..153	CDD:275380
		leucine-rich repeat	154..176	CDD:275380
		leucine-rich repeat	177..199	CDD:275380
		LRR_8	198..256	CDD:290566
		leucine-rich repeat	200..222	CDD:275380
		leucine-rich repeat	223..245	CDD:275380
		LRR_8	267..325	CDD:290566
		leucine-rich repeat	269..289	CDD:275380
		leucine-rich repeat	292..314	CDD:275380
		leucine-rich repeat	315..337	CDD:275380
		LRR_4	337..375	CDD:289563
		leucine-rich repeat	361..382	CDD:275380
		PDZ	728..816	CDD:214570
		PDZ_signaling	931..1016	CDD:238492	19/97 (20%)
		PDZ	1239..1329	CDD:214570	23/93 (25%)
		PDZ_signaling	1336..1425	CDD:238492	13/54 (24%)
degQ	NP_417701.1	PRK10139	1..455	CDD:182262	104/591 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
	1	0.910