DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment scrib and DLG5

DIOPT Version :9

Sequence 1:NP_001163746.1 Gene:scrib / 44448 FlyBaseID:FBgn0263289 Length:2585 Species:Drosophila melanogaster
Sequence 2:NP_004738.3 Gene:DLG5 / 9231 HGNCID:2904 Length:1919 Species:Homo sapiens


Alignment Length:2192 Identity:414/2192 - (18%)
Similarity:722/2192 - (32%) Gaps:746/2192 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   104 HLQSLQVADFSSNPIPKLPSGFSQLKNLTVLGLNDM---------------SLTTLPADFGSLTQ 153
            |.|.|:.|...:.|           ..|.:|.||.:               .|:|:|:|..|.:.
Human    67 HFQDLRAALEKTQP-----------HLLPILYLNGVVGPPQPAEGAGSTYSVLSTMPSDSESSSS 120

  Fly   154 LESLE-----------LRENLLKHLPETIS-QLTKLKRLDLGDNEIEDLPPYLGYLPGLHELWLD 206
            |.|:.           |.:..:....|.:| ||..:.|      |..:|...|.:  ..|....|
Human   121 LSSVGTTGKAPSPPPLLTDQQVNEKVENLSIQLRLMTR------ERNELRKRLAF--ATHGTAFD 177

  Fly   207 HNQLQRLPPELGLLTKLTYLDVSENRLEELPNEISGLVSLTDLDLAQNL-LEALP--DGIAK--- 265
            .....||.|:...|                  :|..:.:::||...||. ..||.  :.:||   
Human   178 KRPYHRLNPDYERL------------------KIQCVRAMSDLQSLQNQHTNALKRCEEVAKETD 224

  Fly   266 ---------LSRLTILKLDQNRLQRLNDTLGNCENMQELILTENFLSELPASIGQMTKLNNLNVD 321
                     ||..|.||.|.:.|:|.|                          ||:.:      :
Human   225 FYHTLHSRLLSDQTRLKDDVDMLRREN--------------------------GQLLR------E 257

  Fly   322 RNALEYLPLEIGQCANLGVLSLRDNKLKKLPPELGNCTVLHVLDVSGNQLLYLPYSLVNLQLKAV 386
            ||.|:.      ...::..|...|.|      |:|:                     :..|.:.|
Human   258 RNLLQQ------SWEDMKRLHEEDQK------EIGD---------------------LRAQQQQV 289

  Fly   387 WLSENQSQPLLTFQPDTDAETGEQVLSCYLLPQQEYQPITPARDLESDSEPFEE-REPSRTVVKF 450
             |..|.|..:|....||..:..|.|...|...::.|.......:  :|....|: .|.::.::|.
Human   290 -LKHNGSSEILNKLYDTAMDKLEVVKKDYDALRKRYSEKVAIHN--ADLSRLEQLGEENQRLLKQ 351

  Fly   451 SEEATQEKETPFVRQN-------------------TPHPKDLKAKAQKLKVERSRNEEHANLVTL 496
            :|..||:::|....|:                   |...|||:.:.:.|:.|.            
Human   352 TEMLTQQRDTAIQLQHQCALSLRRFEAIHHELNKATAQNKDLQWEMELLQSEL------------ 404

  Fly   497 PEENGTKLAETPTETRTIANNHQQQPHPVQQPIVGVNSKQPVVVGVVTPTTTTVAPTGVQGGSEG 561
                 |:|..|..:|...:..::::...|......:.|::..|:..:....|.|.    ...|:.
Human   405 -----TELRTTQVKTAKESEKYREERDAVYSEYKLIMSERDQVISELDKLQTEVE----LAESKL 460

  Fly   562 ASSTANNVKAATAAVVA--ELAATV-----GGSDEVQ-------------DDDEQEDEFESDRRV 606
            .|||:.. |||...:.|  ::..||     ..:.||:             .:..||.:....|| 
Human   461 KSSTSEK-KAANEEMEALRQIKDTVTMDAGRANKEVEILRKQCKALCQELKEALQEADVAKCRR- 523

  Fly   607 GFQVEGEDDDFYKRPPKLHRRDTPH----HLKNKRVQHLTDKQASEILANALASQERNDTTPQHS 667
                   |..|.:|...:..||:..    :|:.:|     |:..|| ||.||.|.:  ||..|  
Human   524 -------DWAFQERDKIVAERDSIRTLCDNLRRER-----DRAVSE-LAEALRSLD--DTRKQ-- 571

  Fly   668 LSGKVTSPIEE-EEQLEVEQEQQQQQQQHPFDSSLSPISAGKTAEASTDPDNLDGVTELRLEQYE 731
             ...|:..::| :||:|.:.|::.:.:|         :.|..:.:::.|.|:::..||:      
Human   572 -KNDVSRELKELKEQMESQLEKEARFRQ---------LMAHSSHDSAIDTDSMEWETEV------ 620

  Fly   732 IHIERTA-----AGLGLSIAGGKGSTPFKGDDDGIFISRVTEAGPADLAGLKVGDKVIKVNGIVV 791
            :..||..     ..||..:|.|.....|.| |.|||:::|.:...|| ..|:|.|.::::|.:.:
Human   621 VEFERETEDIDLKALGFDMAEGVNEPCFPG-DCGIFVTKVDKGSIAD-GRLRVNDWLLRINDVDL 683

  Fly   792 VDADHYQAVQ-VLKACGAVLVLVVQRE------VTRLIGHPVFSEDGSVSQISVETRPLVADAPP 849
            ::.|..||:: :|...||:.::|.:|:      ||.|..:....:|   |.||:|.....|...|
Human   684 INKDKKQAIKALLNGEGAINMVVRRRKSLGGKVVTPLHINLSGQKD---SGISLENGVYAAAVLP 745

  Fly   850 AASISHERYIPAPIEIVP------------QQQHLQQQQQQPIQ----QVAP-THSYSG-NVFAT 896
            .:..:.|..:.....||.            :.:.|.:..|..:.    :|.| :.|:|| |:|..
Human   746 GSPAAKEGSLAVGDRIVAINGIALDNKSLNECESLLRSCQDSLTLSLLKVFPQSSSWSGQNIFEN 810

  Fly   897 PTAAQTV------QPAVSAAPNGLLL---NGREAPLSYIQLHTTLIRDQIGQG--------LGFS 944
            ...:..:      .|.|.|.....|:   |..:..:.|    |..:.|:...|        |...
Human   811 IKDSDKMLSFRAHGPEVQAHNKRNLIQHNNSTQTDIFY----TDRLEDRKEPGPPGGSSSFLHKP 871

  Fly   945 IAGG--------------KGSPPFKDDCDGIFISRITEGGLAYRD--------------GKIMVG 981
            ..||              :....|:.|..|       :.|....|              |...||
Human   872 FPGGPLQVCPQACPSASERSLSSFRSDASG-------DRGFGLVDVRGRRPLLPFETEVGPCGVG 929

  Fly   982 DRVM---AINGNDMTEAHHDAAVACLTEPQRFVRLVLQREYRGPLEPPT--SPRSPAVLNSLSPS 1041
            :..:   ...|::.......|.::....|::.......::.:...:|.|  .|::|..::.|.|.
Human   930 EASLDKADSEGSNSGGTWPKAMLSSTAVPEKLSVYKKPKQRKSIFDPNTFKRPQTPPKIDYLLPG 994

  Fly  1042 GYLANRPANFSRSVVEVEQPYKYNTLATTTPTPKPTVPASISNNNNTLPSSKTNGFATAAAATI- 1105
            ...|:.|           ||.|  .....||...|....||...:....||::......::.:. 
Human   995 PGPAHSP-----------QPSK--RAGPLTPPKPPRRSDSIKFQHRLETSSESEATLVGSSPSTS 1046

  Fly  1106 -------DSSTGQPVPA--PRR------TNSVPMGDGD---IGAGST-----TSGDSGEAQPSSL 1147
                   |...|:|:.|  ||:      ::..|.||||   :.|..:     ||....|......
Human  1047 PPSALPPDVDPGEPMHASPPRKARVRIASSYYPEGDGDSSHLPAKKSCDEDLTSQKVDELGQKRR 1111

  Fly  1148 RPLTSDDFQ-----AMIPAHFL--------SGGSQHQVHVARPNEVGVSAVTVNVNKPQPDLPMF 1199
            ||.::..|:     .:|||.||        ||....::....|...|.|:...|.       |::
Human  1112 RPKSAPSFRPKLAPVVIPAQFLEEQKCVPASGELSPELQEWAPYSPGHSSRHSNP-------PLY 1169

  Fly  1200 PAAPTELGRVTETITKSTFTETVM--------------------TRITDNQLAEPLISEEVVLPK 1244
            |:.|: :|.|..::|.||...:::                    .|....|...|.:       :
Human  1170 PSRPS-VGTVPRSLTPSTTVSSILRNPIYTVRSHRVGPCSSPPAARDAGPQGLHPSV-------Q 1226

  Fly  1245 NQGSLGFSIIGGT--DHS------------------------------CVPFGTREPGIF----- 1272
            :||.|...:...|  |:|                              .:|...|.|...     
Human  1227 HQGRLSLDLSHRTCSDYSEMRATHGSNSLPSSARLGSSSNLQFKAERIKIPSTPRYPRSVVGSER 1291

  Fly  1273 --ISHIVPGGIASKCGKLRMG----DRILKVNEADVSKATHQDAVLELLKPGDEIKLTIQHDPLP 1331
              :||       |:|......    |.:...:::..|.:|.....:.....|:..|    ..|..
Human  1292 GSVSH-------SECSTPPQSPLNIDTLSSCSQSQTSASTLPRIAVNPASLGERRK----DRPYV 1345

  Fly  1332 PGFQEVLLSKAEGERLGMHIKGGLNGQRGNPADPSDEGVFVSKINSVGAARRDGRLKVGMRLLEV 1396
            ...:.|.:.|. .|.||:.|   ::|::|        |::|||: :||:......|:.|.:|||.
Human  1346 EEPRHVKVQKG-SEPLGISI---VSGEKG--------GIYVSKV-TVGSIAHQAGLEYGDQLLEF 1397

  Fly  1397 NGHSLLGASHQDAVNVLRNAGNEIQLVVCKGYDKSNL-------IHSIGQAGGMSTGFNSSASCS 1454
            ||.:|..|:.|.|           :|::.:..|...:       :|.:.         :.|.|.|
Human  1398 NGINLRSATEQQA-----------RLIIGQQCDTITILAQYNPHVHQLS---------SHSRSSS 1442

  Fly  1455 GGSRQGSRASETGSELSQSQSVSSLDHEEDERLRQDFDVFASQKPDAQQPTGPSVLAAAAAMVHG 1519
            .....|:.::..||..:..:..|.:|                  |..:|..|||           
Human  1443 HLDPAGTHSTLQGSGTTTPEHPSVID------------------PLMEQDEGPS----------- 1478

  Fly  1520 ASSPTPPAATSNITPLPTAAAVASADLTAPDTPATQTVALIHAEQQAHQQQQQTQLAPLGQEKST 1584
                ||||                                         :|..:::|....:|:.
Human  1479 ----TPPA-----------------------------------------KQSSSRIAGDANKKTL 1498

  Fly  1585 QEKVLEIVRAADAFTTVPPKSPSEHHEQDKIQKTTTVVISKHTLDTNPTTPTTPAAPLSIAGAES 1649
            :.:|:.|                         |.:.:.:..|....|       ...:.:|..|.
Human  1499 EPRVVFI-------------------------KKSQLELGVHLCGGN-------LHGVFVAEVED 1531

  Fly  1650 ANSAGAPSPAVPASTPGSAPVLPAVAVQTQTQTTSTEKDEEEESQLQSTPASRDGAE-----EQQ 1709
            .:.|..|...||...     :|...::..:.:|.       ||..::.. ..|||..     ..:
Human  1532 DSPAKGPDGLVPGDL-----ILEYGSLDVRNKTV-------EEVYVEML-KPRDGVRLKVQYRPE 1583

  Fly  1710 EEVRAKPTP-------------TKVPKSVSDKKRFFESAMEDQHKPTQKTDKVFSFLSKDEVEKL 1761
            |..:||..|             ..|.:.:|.||.  :....|...|........::...:..:|:
Human  1584 EFTKAKGLPGDSFYIRALYDRLADVEQELSFKKD--DILYVDDTLPQGTFGSWMAWQLDENAQKI 1646

  Fly  1762 R-----------QEEERKIATLR-RDKNS--RLLDAANDNIDKDAAQQRTKSNSNSSSGDDND-- 1810
            :           ||..|:::... :|.||  :.|.||    .:.:..:|...:..|.|.|..|  
Human  1647 QRGQIPSKYVMDQEFSRRLSMSEVKDDNSATKTLSAA----ARRSFFRRKHKHKRSGSKDGKDLL 1707

  Fly  1811 -----DSDQ----EEGIA----RGDSVDNAA------LGHFDDAEDMRTAQSLASTMPHAPSKIP 1856
                 .||.    |:.::    |...||..|      ||...|.    ..:.|.:..|....:.|
Human  1708 ALDAFSSDSIPLFEDSVSLAYQRVQKVDCTALRPVLILGPLLDV----VKEMLVNEAPGKFCRCP 1768

  Fly  1857 KQKLKAKQ--IESSLPTPTALDPPKPS----LLPKPKVKVV----------IPPALQQRL----- 1900
            .:.:||.|  ||..:.....:|..:.|    :.....:|.:          |.|...:||     
Human  1769 LEVMKASQQAIERGVKDCLFVDYKRRSGHFDVTTVASIKEITEKNRHCLLDIAPHAIERLHHMHI 1833

  Fly  1901 ----------KQQQVQQQQ----------QQHQQSQPEEPSIPEEEY 1927
                      ..:.:::|:          |:|.:.|.|.....|:||
Human  1834 YPIVIFIHYKSAKHIKEQRDPIYLRDKVTQRHSKEQFEAAQKLEQEY 1880

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
scribNP_001163746.1 LRR_RI 13..283 CDD:238064 48/220 (22%)
leucine-rich repeat 18..38 CDD:275380
LRR_8 37..95 CDD:290566
leucine-rich repeat 39..61 CDD:275380
leucine-rich repeat 62..84 CDD:275380
LRR_8 84..138 CDD:290566 8/33 (24%)
leucine-rich repeat 85..107 CDD:275380 1/2 (50%)
leucine-rich repeat 108..130 CDD:275380 3/21 (14%)
LRR_8 129..187 CDD:290566 17/84 (20%)
leucine-rich repeat 131..153 CDD:275380 9/36 (25%)
leucine-rich repeat 154..176 CDD:275380 7/33 (21%)
leucine-rich repeat 177..199 CDD:275380 4/21 (19%)
LRR_8 198..256 CDD:290566 11/58 (19%)
leucine-rich repeat 200..222 CDD:275380 6/21 (29%)
leucine-rich repeat 223..245 CDD:275380 1/21 (5%)
LRR_8 267..325 CDD:290566 12/57 (21%)
leucine-rich repeat 269..289 CDD:275380 7/19 (37%)
leucine-rich repeat 292..314 CDD:275380 2/21 (10%)
leucine-rich repeat 315..337 CDD:275380 3/21 (14%)
LRR_4 337..375 CDD:289563 5/37 (14%)
leucine-rich repeat 361..382 CDD:275380 0/20 (0%)
PDZ 728..816 CDD:214570 26/93 (28%)
PDZ_signaling 931..1016 CDD:238492 16/123 (13%)
PDZ 1239..1329 CDD:214570 18/132 (14%)
PDZ_signaling 1336..1425 CDD:238492 26/88 (30%)
DLG5NP_004738.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 98..142 8/43 (19%)
Takusan 130..212 CDD:282652 20/107 (19%)
TPR_MLP1_2 231..353 CDD:285204 35/189 (19%)
COG1340 295..587 CDD:224259 70/334 (21%)
FliJ 310..449 CDD:304890 26/157 (17%)
BAR 417..601 CDD:299863 46/216 (21%)
PDZ_signaling 620..707 CDD:238492 25/94 (27%)
DegQ <702..771 CDD:223343 15/71 (21%)
PDZ_signaling 722..790 CDD:238492 12/70 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 927..1122 41/207 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1150..1187 11/44 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1201..1230 4/35 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1245..1264 0/18 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1271..1306 7/41 (17%)
PDZ 1347..1429 CDD:214570 27/105 (26%)
dbPDZ_assoc 1427..1499 CDD:293216 21/154 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1434..1493 19/141 (13%)
PDZ 1499..1582 CDD:214570 18/127 (14%)
SH3_DLG5 1597..1659 CDD:212794 7/63 (11%)
GuKc 1732..1908 CDD:214504 29/153 (19%)
Guanylate_kin 1740..1907 CDD:279019 26/145 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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