DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment scrib and RPP27

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	NP_175849.2	Gene:	RPP27 / 841889	AraportID:	AT1G54470	Length:	457	Species:	Arabidopsis thaliana

Alignment Length:	299	Identity:	84/299 - (28%)
Similarity:	127/299 - (42%)	Gaps:	55/299 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 SSNPIPKLPSGFSQLKNLTVLGLNDMSLTTLPADFGSLTQLESLELRENLLKHLP--ETISQLTK 176
            :|..:.:|..|.|.||..::|.::.:.         ...::.||||...|...:.  |....|.|
plant   176 TSGRLIRLHVGASNLKENSLLNISLLH---------PFEEVRSLELSAGLNGFVDNVEGYKSLRK 231

  Fly   177 LKRLDLGDNEIEDLPPYLGYLPGLHELWLDHNQL-QRLPPELGLLTKLTYLDVSENRLE-ELP-N 238
            ||.|::.|         |.|          :|:. ..:.|.:...|.||.|.:..|.:| ..| .
plant   232 LKNLEILD---------LSY----------NNRFNNNILPFINAATSLTSLSLQNNSMEGPFPFE 277

  Fly   239 EISGLVSLTDLDLAQNLLEALPDGIAKLSRLTILKLDQNRLQRLNDTLGNCE--NMQELILTEN- 300
            ||..|.:|..|||::|:|:....|:..|.:|..|.|..|....:.:....||  |:.||.|.||
plant   278 EIKDLTNLKLLDLSRNILKGPMQGLTHLKKLKALDLSNNVFSSIMELQVVCEMKNLWELDLRENK 342

  Fly   301 FLSELPASIGQMTKLNNLNVDRNALE-YLPLEIGQCANLGVLSLRDNKLK---KLPPELGNCTVL 361
            |:.:||..:|::.||..|::..|.|. .||....:..:|..|||.||...   ...| |.|.|.|
plant   343 FVGQLPLCLGRLNKLRVLDLSSNQLNGNLPSTFNRLESLEYLSLLDNNFTGFFSFDP-LANLTKL 406

  Fly   362 HVLDVSGNQLLYLPYSLVNLQLKAVWLSENQSQPLLTFQ 400
            .|..:|....:        ||:|      .:|:|...||
plant   407 KVFKLSSTSDM--------LQIK------TESEPKYQFQ 431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064	45/173 (26%)
		leucine-rich repeat	18..38	CDD:275380
		LRR_8	37..95	CDD:290566
		leucine-rich repeat	39..61	CDD:275380
		leucine-rich repeat	62..84	CDD:275380
		LRR_8	84..138	CDD:290566	7/23 (30%)
		leucine-rich repeat	85..107	CDD:275380
		leucine-rich repeat	108..130	CDD:275380	5/15 (33%)
		LRR_8	129..187	CDD:290566	14/59 (24%)
		leucine-rich repeat	131..153	CDD:275380	1/21 (5%)
		leucine-rich repeat	154..176	CDD:275380	7/23 (30%)
		leucine-rich repeat	177..199	CDD:275380	6/21 (29%)
		LRR_8	198..256	CDD:290566	17/60 (28%)
		leucine-rich repeat	200..222	CDD:275380	2/22 (9%)
		leucine-rich repeat	223..245	CDD:275380	9/23 (39%)
		LRR_8	267..325	CDD:290566	20/60 (33%)
		leucine-rich repeat	269..289	CDD:275380	4/19 (21%)
		leucine-rich repeat	292..314	CDD:275380	9/22 (41%)
		leucine-rich repeat	315..337	CDD:275380	6/22 (27%)
		LRR_4	337..375	CDD:289563	13/40 (33%)
		leucine-rich repeat	361..382	CDD:275380	3/20 (15%)
		PDZ	728..816	CDD:214570
		PDZ_signaling	931..1016	CDD:238492
		PDZ	1239..1329	CDD:214570
		PDZ_signaling	1336..1425	CDD:238492
RPP27	NP_175849.2	LRRNT_2	130..174	CDD:285463
		LRR_RI	<211..367	CDD:238064	52/174 (30%)
		leucine-rich repeat	235..259	CDD:275380	6/42 (14%)
		LRR_8	258..316	CDD:290566	21/57 (37%)
		leucine-rich repeat	260..284	CDD:275380	9/23 (39%)
		LRR_8	283..367	CDD:290566	28/83 (34%)
		leucine-rich repeat	285..307	CDD:275380	8/21 (38%)
		leucine-rich repeat	308..332	CDD:275380	6/23 (26%)
		leucine-rich repeat	333..356	CDD:275380	9/22 (41%)
		leucine-rich repeat	357..380	CDD:275380	6/22 (27%)
		leucine-rich repeat	381..405	CDD:275380	9/24 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910