DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scrib and PIRL3

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	NP_563921.1	Gene:	PIRL3 / 837855	AraportID:	AT1G12970	Length:	464	Species:	Arabidopsis thaliana

Alignment Length:	273	Identity:	87/273 - (31%)
Similarity:	125/273 - (45%)	Gaps:	47/273 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 LRKLGLSDNEIGRLPPDIQNFENLVELDVSRNDIPDIPDDIKHLQSLQVADFSSNPIPKLPSGFS 126
            :.::.|||:|:..||..:.....||.|:||||::..:||.|..|:.|:..|.|||.:..||....
plant   163 VERIDLSDHELKLLPDALGKIVGLVSLNVSRNNLRFLPDTISGLEKLEELDLSSNRLVFLPDSIG 227

  Fly   127 QLKNLTVLGLNDMSLTTLPADFGSLTQLESLELRENLLKHLPETISQLTKLKRLDLGDNEIEDLP 191
            .|.||.:|.:....||.                       |||:|:|...|..||...|.:..||
plant   228 LLLNLRILNVTGNKLTL-----------------------LPESIAQCRSLVELDASFNNLTSLP 269

  Fly   192 PYLGYLPGLHELWLDHNQLQRLPPELGLLTKLTYLDVSENRLEELPNEISGLVSLTDLDLAQNLL 256
            ...||                     ||| .|..|.:..|::...||.|..:.||..||...|.:
plant   270 ANFGY---------------------GLL-NLERLSIQLNKIRFFPNSICEMRSLRYLDAHMNEI 312

  Fly   257 EALPDGIAKLSRLTILKLDQN--RLQRLNDTLGNCENMQELILTENFLSELPASIGQMTKLNNLN 319
            ..||..|.:|:.|.::.|..|  .|..|.||:.:..|::||.|:.|.:..||.|..::.||..||
plant   313 HGLPIAIGRLTNLEVMNLSSNFSDLIELPDTISDLANLRELDLSNNQIRVLPDSFFRLEKLEKLN 377

  Fly   320 VDRNALEYLPLEI 332
            :|:|.|||.|.|:
plant   378 LDQNPLEYPPQEM 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064	65/222 (29%)
		leucine-rich repeat	18..38	CDD:275380
		LRR_8	37..95	CDD:290566	13/32 (41%)
		leucine-rich repeat	39..61	CDD:275380
		leucine-rich repeat	62..84	CDD:275380	6/21 (29%)
		LRR_8	84..138	CDD:290566	22/53 (42%)
		leucine-rich repeat	85..107	CDD:275380	11/21 (52%)
		leucine-rich repeat	108..130	CDD:275380	8/21 (38%)
		LRR_8	129..187	CDD:290566	14/57 (25%)
		leucine-rich repeat	131..153	CDD:275380	4/21 (19%)
		leucine-rich repeat	154..176	CDD:275380	5/21 (24%)
		leucine-rich repeat	177..199	CDD:275380	8/21 (38%)
		LRR_8	198..256	CDD:290566	14/57 (25%)
		leucine-rich repeat	200..222	CDD:275380	3/21 (14%)
		leucine-rich repeat	223..245	CDD:275380	6/21 (29%)
		LRR_8	267..325	CDD:290566	21/59 (36%)
		leucine-rich repeat	269..289	CDD:275380	7/21 (33%)
		leucine-rich repeat	292..314	CDD:275380	7/21 (33%)
		leucine-rich repeat	315..337	CDD:275380	10/18 (56%)
		LRR_4	337..375	CDD:289563
		leucine-rich repeat	361..382	CDD:275380
		PDZ	728..816	CDD:214570
		PDZ_signaling	931..1016	CDD:238492
		PDZ	1239..1329	CDD:214570
		PDZ_signaling	1336..1425	CDD:238492
PIRL3	NP_563921.1	leucine-rich repeat	163..185	CDD:275380	6/21 (29%)
		LRR	<185..385	CDD:227223	77/244 (32%)
		leucine-rich repeat	186..208	CDD:275380	11/21 (52%)
		leucine-rich repeat	209..231	CDD:275380	8/21 (38%)
		leucine-rich repeat	232..254	CDD:275380	9/44 (20%)
		leucine-rich repeat	255..278	CDD:275380	11/44 (25%)
		leucine-rich repeat	279..301	CDD:275380	6/21 (29%)
		leucine-rich repeat	302..324	CDD:275380	8/21 (38%)
		leucine-rich repeat	325..349	CDD:275380	7/23 (30%)
		leucine-rich repeat	350..372	CDD:275380	7/21 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm3538
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910