DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment scrib and LRR XI-23

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	NP_172468.3	Gene:	LRR XI-23 / 837531	AraportID:	AT1G09970	Length:	977	Species:	Arabidopsis thaliana

Alignment Length:	431	Identity:	122/431 - (28%)
Similarity:	206/431 - (47%)	Gaps:	48/431 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 PIFKGCNRQVEFVDKRHCSLPQV-PEEILRYSRTLEELFLDANHI---RDLPKNFFRLHRLRKLG 66
            |.|...| |::|:...:.:...| |.:.||.:.:|..|.|..|..   .|.|.....|.:|..|.
plant   138 PEFSSLN-QLQFLYLNNSAFSGVFPWKSLRNATSLVVLSLGDNPFDATADFPVEVVSLKKLSWLY 201

  Fly    67 LSDNEI-GRLPPDIQNFENLVELDVSRNDIP-DIPDDIKHLQSLQVADFSSNPIP-KLPSGFSQL 128
            ||:..| |::||.|.:...|..|::|.:.:. :||.:|..|.:|...:..:|.:. |||:||..|
plant   202 LSNCSIAGKIPPAIGDLTELRNLEISDSGLTGEIPSEISKLTNLWQLELYNNSLTGKLPTGFGNL 266

  Fly   129 KNLTVLGLNDMSLTTLPADFG---SLTQLESLELRENLLK-HLPETISQLTKLKRLDLGDNEIE- 188
            ||||.|   |.|...|..|..   |||.|.||::.||... .:|....:...|..|.|..|::.
plant   267 KNLTYL---DASTNLLQGDLSELRSLTNLVSLQMFENEFSGEIPLEFGEFKDLVNLSLYTNKLTG 328

  Fly   189 DLPPYLGYLPGLHELWLDHNQLQ-RLPPELGLLTKLTYLDVSENRLE-ELPNEISGLVSLTDLDL 251
            .||..||.|.....:....|.|. .:||::....|:..|.:.:|.|. .:|...:..::|....:
plant   329 SLPQGLGSLADFDFIDASENLLTGPIPPDMCKNGKMKALLLLQNNLTGSIPESYANCLTLQRFRV 393

  Fly   252 AQNLLE-ALPDGIAKLSRLTILKLDQNRLQ---------------------RLNDTL----GNCE 290
            ::|.|. .:|.|:..|.:|.|:.::.|..:                     :|:|.|    |:.|
plant   394 SENNLNGTVPAGLWGLPKLEIIDIEMNNFEGPITADIKNGKMLGALYLGFNKLSDELPEEIGDTE 458

  Fly   291 NMQELILTEN-FLSELPASIGQMTKLNNLNVDRNALE-YLPLEIGQCANLGVLSLRDNKLK-KLP 352
            ::.::.|..| |..::|:|||::..|::|.:..|... .:|..||.|:.|..:::..|.:. ::|
plant   459 SLTKVELNNNRFTGKIPSSIGKLKGLSSLKMQSNGFSGEIPDSIGSCSMLSDVNMAQNSISGEIP 523

  Fly   353 PELGNCTVLHVLDVSGNQLL-YLPYSLVNLQLKAVWLSENQ 392
            ..||:...|:.|::|.|:|. .:|.||.:|:|..:.||.|:
plant   524 HTLGSLPTLNALNLSDNKLSGRIPESLSSLRLSLLDLSNNR 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064	82/305 (27%)
		leucine-rich repeat	18..38	CDD:275380	4/20 (20%)
		LRR_8	37..95	CDD:290566	19/61 (31%)
		leucine-rich repeat	39..61	CDD:275380	7/24 (29%)
		leucine-rich repeat	62..84	CDD:275380	9/22 (41%)
		LRR_8	84..138	CDD:290566	20/55 (36%)
		leucine-rich repeat	85..107	CDD:275380	7/22 (32%)
		leucine-rich repeat	108..130	CDD:275380	8/22 (36%)
		LRR_8	129..187	CDD:290566	22/61 (36%)
		leucine-rich repeat	131..153	CDD:275380	9/24 (38%)
		leucine-rich repeat	154..176	CDD:275380	6/22 (27%)
		leucine-rich repeat	177..199	CDD:275380	9/22 (41%)
		LRR_8	198..256	CDD:290566	11/59 (19%)
		leucine-rich repeat	200..222	CDD:275380	4/22 (18%)
		leucine-rich repeat	223..245	CDD:275380	4/22 (18%)
		LRR_8	267..325	CDD:290566	18/83 (22%)
		leucine-rich repeat	269..289	CDD:275380	7/44 (16%)
		leucine-rich repeat	292..314	CDD:275380	7/22 (32%)
		leucine-rich repeat	315..337	CDD:275380	7/22 (32%)
		LRR_4	337..375	CDD:289563	10/39 (26%)
		leucine-rich repeat	361..382	CDD:275380	8/21 (38%)
		PDZ	728..816	CDD:214570
		PDZ_signaling	931..1016	CDD:238492
		PDZ	1239..1329	CDD:214570
		PDZ_signaling	1336..1425	CDD:238492
LRR XI-23	NP_172468.3	PLN00113	14..955	CDD:331614	122/431 (28%)
		leucine-rich repeat	74..98	CDD:275380
		leucine-rich repeat	99..122	CDD:275380
		leucine-rich repeat	123..145	CDD:275380	3/7 (43%)
		leucine-rich repeat	146..170	CDD:275380	5/23 (22%)
		leucine-rich repeat	171..196	CDD:275380	7/24 (29%)
		leucine-rich repeat	197..220	CDD:275380	9/22 (41%)
		leucine-rich repeat	221..244	CDD:275380	7/22 (32%)
		leucine-rich repeat	245..268	CDD:275380	8/22 (36%)
		leucine-rich repeat	269..291	CDD:275380	9/24 (38%)
		leucine-rich repeat	292..310	CDD:275380	6/17 (35%)
		leucine-rich repeat	316..340	CDD:275380	9/23 (39%)
		leucine-rich repeat	341..363	CDD:275380	4/21 (19%)
		leucine-rich repeat	364..387	CDD:275380	4/22 (18%)
		leucine-rich repeat	388..411	CDD:275380	6/22 (27%)
		leucine-rich repeat	412..435	CDD:275380	3/22 (14%)
		leucine-rich repeat	436..459	CDD:275380	4/22 (18%)
		leucine-rich repeat	460..483	CDD:275380	7/22 (32%)
		leucine-rich repeat	484..507	CDD:275380	7/22 (32%)
		leucine-rich repeat	508..531	CDD:275380	5/22 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910