DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scrib and ERL2

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	NP_196335.2	Gene:	ERL2 / 830609	AraportID:	AT5G07180	Length:	967	Species:	Arabidopsis thaliana

Alignment Length:	886	Identity:	205/886 - (23%)
Similarity:	330/886 - (37%)	Gaps:	259/886 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 QVPEEI--------LRYSRTLEELFLDANHIRDLPKNFFRLHRLRKLGLSDNEI-GRLPPDIQNF 82
            |:|:||        :.:|..|  ||      .|:|.:..:|.:|..|.|.:|:: |.:|..:...
plant   112 QIPDEIGNCVSLAYVDFSTNL--LF------GDIPFSISKLKQLEFLNLKNNQLTGPIPATLTQI 168

  Fly    83 ENLVELDVSRNDIP-DIPDDIKHLQSLQVADFSSNPIP-KLPSGFSQLKNLTVLGLNDMSLT-TL 144
            .||..||::||.:. :||..:...:.||......|.:. .|.....||..|....:...:|| |:
plant   169 PNLKTLDLARNQLTGEIPRLLYWNEVLQYLGLRGNMLTGTLSPDMCQLTGLWYFDVRGNNLTGTI 233

  Fly   145 PADFGSLTQLESLELREN------------------------LLKHLPETISQLTKLKRLDLGDN 185
            |...|:.|..|.|::..|                        |...:||.|..:..|..|||.||
plant   234 PESIGNCTSFEILDVSYNQITGVIPYNIGFLQVATLSLQGNKLTGRIPEVIGLMQALAVLDLSDN 298

  Fly   186 EIE-DLPPYLGYLPGLHELWLDHNQLQ-RLPPELGLLTKLTYLDVSENRL-EELPNEISGLVSLT 247
            |:. .:||.||.|....:|:|..|:|. ::|||||.:::|:||.:::|.| .::|.|:..|..|.
plant   299 ELTGPIPPILGNLSFTGKLYLHGNKLTGQIPPELGNMSRLSYLQLNDNELVGKIPPELGKLEQLF 363

  Fly   248 DLDLA-QNLLEALPDGIA------------------------KLSRLTILKLDQNRLQ-RLNDTL 286
            :|:|| .||:..:|..|:                        .|..||.|.|..|..: ::...|
plant   364 ELNLANNNLVGLIPSNISSCAALNQFNVHGNFLSGAVPLEFRNLGSLTYLNLSSNSFKGKIPAEL 428

  Fly   287 GNCENMQELILT-ENFLSELPASIGQMTKLNNLNVDRNALE------------------------ 326
            |:..|:..|.|: .||...:|.::|.:..|..||:.||.|.
plant   429 GHIINLDTLDLSGNNFSGSIPLTLGDLEHLLILNLSRNHLNGTLPAEFGNLRSIQIIDVSFNFLA 493

  Fly   327 -YLPLEIGQCANLGVLSLRDNKLK-KLPPELGNCTVLHVLDVS---------------------- 367
             .:|.|:||..|:..|.|.:||:. |:|.:|.||..|..|::|
plant   494 GVIPTELGQLQNINSLILNNNKIHGKIPDQLTNCFSLANLNISFNNLSGIIPPMKNFTRFSPASF 558

  Fly   368 -GNQLL-----------YLPYS-----------------LVNLQLKAVWLSENQSQPLL---TFQ 400
             ||..|           .||.|                 |:.:...||:.|: |.:|:|   :.|
plant   559 FGNPFLCGNWVGSICGPSLPKSQVFTRVAVICMVLGFITLICMIFIAVYKSK-QQKPVLKGSSKQ 622

  Fly   401 PDTDAETGEQVLSCYLLPQQEYQPITPARDLESDSEPFEER-----EPSRTVVKFSEEATQEKET 460
            |:.         |..|:.......|....|:...:|..:|:     ..|.||.|    .|.:...
plant   623 PEG---------STKLVILHMDMAIHTFDDIMRVTENLDEKYIIGYGASSTVYK----CTSKTSR 674

  Fly   461 PFV--RQNTPHPKDLKAKAQKLKVERSRNEEHANLVTLP---------------EENGT------ 502
            |..  |....:|.:.:....:|  |...:..|.|:|:|.               .|||:
plant   675 PIAIKRIYNQYPSNFREFETEL--ETIGSIRHRNIVSLHGYALSPFGNLLFYDYMENGSLWDLLH 737

  Fly   503 ---KLAETPTETR-TIA---------NNHQQQPHPVQQPIVGVN-----------SKQPVVVGVV 543
               |..:...||| .||         .:|...|..:.:.|...|           |...:...:
plant   738 GPGKKVKLDWETRLKIAVGAAQGLAYLHHDCTPRIIHRDIKSSNILLDGNFEARLSDFGIAKSI- 801

  Fly   544 TPTTTTVAPTGVQG-----GSEGASSTANNVKAATAAVVAELAATVGGSDEVQDDDEQEDEFES- 602
             |.|.|.|.|.|.|     ..|.|.::..|.|:...:....|...:.|...|.::........|
plant   802 -PATKTYASTYVLGTIGYIDPEYARTSRLNEKSDIYSFGIVLLELLTGKKAVDNEANLHQMILSK 865

  Fly   603 --DRRVGFQVEGE------DDDFYKRPPKLHRRDTPHHLKNKRVQHLTDKQASEILANALASQER 659
              |..|...|:.|      |....|:..:|....|    |...::..|.::.|.:|.:.:.|
plant   866 ADDNTVMEAVDAEVSVTCMDSGHIKKTFQLALLCT----KRNPLERPTMQEVSRVLLSLVPS--- 923

  Fly   660 NDTTPQHSLSGKVTSPIEEEEQLEVEQEQQQQQQQHPFDSS 700
              ..|:     |:.||.:       .||.:::::.|..|::
plant   924 --PPPK-----KLPSPAK-------VQEGEERRESHSSDTT 950

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064	88/320 (28%)
		leucine-rich repeat	18..38	CDD:275380	5/18 (28%)
		LRR_8	37..95	CDD:290566	18/58 (31%)
		leucine-rich repeat	39..61	CDD:275380	6/21 (29%)
		leucine-rich repeat	62..84	CDD:275380	6/22 (27%)
		LRR_8	84..138	CDD:290566	15/55 (27%)
		leucine-rich repeat	85..107	CDD:275380	7/22 (32%)
		leucine-rich repeat	108..130	CDD:275380	6/22 (27%)
		LRR_8	129..187	CDD:290566	20/82 (24%)
		leucine-rich repeat	131..153	CDD:275380	6/22 (27%)
		leucine-rich repeat	154..176	CDD:275380	7/45 (16%)
		leucine-rich repeat	177..199	CDD:275380	12/22 (55%)
		LRR_8	198..256	CDD:290566	22/60 (37%)
		leucine-rich repeat	200..222	CDD:275380	9/22 (41%)
		leucine-rich repeat	223..245	CDD:275380	8/22 (36%)
		LRR_8	267..325	CDD:290566	19/59 (32%)
		leucine-rich repeat	269..289	CDD:275380	7/20 (35%)
		leucine-rich repeat	292..314	CDD:275380	6/22 (27%)
		leucine-rich repeat	315..337	CDD:275380	10/46 (22%)
		LRR_4	337..375	CDD:289563	16/72 (22%)
		leucine-rich repeat	361..382	CDD:275380	10/71 (14%)
		PDZ	728..816	CDD:214570
		PDZ_signaling	931..1016	CDD:238492
		PDZ	1239..1329	CDD:214570
		PDZ_signaling	1336..1425	CDD:238492
ERL2	NP_196335.2	PLN00113	14..919	CDD:215061	196/836 (23%)
		leucine-rich repeat	77..98	CDD:275380
		leucine-rich repeat	99..122	CDD:275380	4/9 (44%)
		leucine-rich repeat	123..146	CDD:275380	7/30 (23%)
		leucine-rich repeat	147..170	CDD:275380	6/22 (27%)
		leucine-rich repeat	171..218	CDD:275380	13/46 (28%)
		leucine-rich repeat	219..242	CDD:275380	6/22 (27%)
		leucine-rich repeat	243..265	CDD:275380	3/21 (14%)
		leucine-rich repeat	268..289	CDD:275380	4/20 (20%)
		leucine-rich repeat	290..313	CDD:275380	12/22 (55%)
		leucine-rich repeat	314..337	CDD:275380	9/22 (41%)
		leucine-rich repeat	338..361	CDD:275380	8/22 (36%)
		leucine-rich repeat	362..409	CDD:275380	9/46 (20%)
		leucine-rich repeat	410..433	CDD:275380	7/22 (32%)
		leucine-rich repeat	434..457	CDD:275380	6/22 (27%)
		leucine-rich repeat	458..481	CDD:275380	6/22 (27%)
		leucine-rich repeat	482..529	CDD:275380	14/46 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910