DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment scrib and AT3G15410

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	NP_001189901.1	Gene:	AT3G15410 / 820780	AraportID:	AT3G15410	Length:	590	Species:	Arabidopsis thaliana

Alignment Length:	503	Identity:	151/503 - (30%)
Similarity:	226/503 - (44%)	Gaps:	83/503 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 EEILRYSRTLEELFLDANHIR------DLPKNFFRLHRLRKLGLSDNEIGRLPPDIQNFENLVEL 88
            :.||:.:||...|.|....:.      |:|...::.  |...|..:|....:  |:|      :|
plant     2 DRILKAARTSGSLNLSNRSLNFDPITWDVPTEVYQC--LETTGEGENWWEAV--DLQ------KL 56

  Fly    89 DVSRNDIPDIPDDIKHLQSLQVADFSSNPIPKLPSGFSQLKNLTVLGLNDMSLTTLPADFGSLTQ 153
            .::.|||..:.:|:|:|..|.|.:.|.|                       .|:.|||..|.||.
plant    57 ILAHNDIEVLREDLKNLACLVVLNVSHN-----------------------KLSQLPAAIGELTA 98

  Fly   154 LESLELRENLLKHLPETISQLTKLKRLDLGDNEIEDLPPYLGYLPGLHELWLDHNQLQRLPPELG 218
            ::||::..|.:..|||.|.....|.:||...|.:::||..:|....|.:|...:||:..||.::.
plant    99 MKSLDVSFNSISELPEQIGSAISLVKLDCSSNRLKELPDSIGRCLDLSDLKATNNQISSLPEDMV 163

  Fly   219 LLTKLTYLDVSENRLEEL-PNEISGLVSLTDLDLAQNLLEALPDGIAKLSRLTILKLDQNRLQRL 282
            ..:||:.|||..|:|..| .|.|:....|.:|:..:|:|..||..|..||||..|.|.||::..:
plant   164 NCSKLSKLDVEGNKLTALSENHIASWTMLAELNACKNMLGVLPQNIGSLSRLIRLDLHQNKISSV 228

  Fly   283 NDTLGNCENMQELILTENFLSELPASIGQMTKLNNLNVDRNALEYLPLEIGQC-ANLGVLSLRDN 346
            ..::|.|.::.|..|..|.||.|||.||.:::|..|::..|.|:..|  :|.| ..|..|.|.:|
plant   229 PPSIGGCSSLVEFYLGINSLSTLPAEIGDLSRLGTLDLRSNQLKEYP--VGACKLKLSYLDLSNN 291

  Fly   347 KLKKLPPELGNCTVLHVLDVSGNQLLYLPYSLVNLQLKAVWLSENQSQPLLTFQPDTDAETGEQV 411
            .|..|.|||||.|.|..|.:.||.|..|..||||....|: |...:|:  |:...:|.|.|
plant   292 SLTGLHPELGNMTTLRKLVLVGNPLRTLRSSLVNGPTAAL-LKYLRSR--LSNSEETSAST---- 349

  Fly   412 LSCYLLPQQEYQPITPAR--------DLE----SD--SEPFEEREPSRTVVKFSEEATQEKETPF 462
                  |.:|....:.||        .||    ||  ||.:|..|  .|.|..|:.:.:|
plant   350 ------PTKENVIASAARMSISSKELSLEGLNLSDVPSEVWESGE--ITKVNLSKNSIEE----- 401

  Fly   463 VRQNTPHPKDLKAKAQKLKVERSRNEE--HANLVTLPEENGTKLAETP 508
                .|.........|.|.:.|::.::  .|.|.:||.....||...|
plant   402 ----LPAQLSTSVSLQTLILSRNKIKDWPGAILKSLPNLMCLKLDNNP 445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064	76/259 (29%)
		leucine-rich repeat	18..38	CDD:275380	2/7 (29%)
		LRR_8	37..95	CDD:290566	13/63 (21%)
		leucine-rich repeat	39..61	CDD:275380	4/27 (15%)
		leucine-rich repeat	62..84	CDD:275380	5/21 (24%)
		LRR_8	84..138	CDD:290566	11/53 (21%)
		leucine-rich repeat	85..107	CDD:275380	7/21 (33%)
		leucine-rich repeat	108..130	CDD:275380	4/21 (19%)
		LRR_8	129..187	CDD:290566	18/57 (32%)
		leucine-rich repeat	131..153	CDD:275380	6/21 (29%)
		leucine-rich repeat	154..176	CDD:275380	7/21 (33%)
		leucine-rich repeat	177..199	CDD:275380	7/21 (33%)
		LRR_8	198..256	CDD:290566	19/58 (33%)
		leucine-rich repeat	200..222	CDD:275380	6/21 (29%)
		leucine-rich repeat	223..245	CDD:275380	9/22 (41%)
		LRR_8	267..325	CDD:290566	22/57 (39%)
		leucine-rich repeat	269..289	CDD:275380	6/19 (32%)
		leucine-rich repeat	292..314	CDD:275380	10/21 (48%)
		leucine-rich repeat	315..337	CDD:275380	7/22 (32%)
		LRR_4	337..375	CDD:289563	17/37 (46%)
		leucine-rich repeat	361..382	CDD:275380	10/20 (50%)
		PDZ	728..816	CDD:214570
		PDZ_signaling	931..1016	CDD:238492
		PDZ	1239..1329	CDD:214570
		PDZ_signaling	1336..1425	CDD:238492
AT3G15410	NP_001189901.1	LRR_8	53..109	CDD:290566	22/84 (26%)
		leucine-rich repeat	53..75	CDD:275380	8/27 (30%)
		leucine-rich repeat	76..98	CDD:275380	10/44 (23%)
		leucine-rich repeat	99..121	CDD:275380	7/21 (33%)
		leucine-rich repeat	122..137	CDD:275380	5/14 (36%)
		leucine-rich repeat	145..167	CDD:275380	6/21 (29%)
		leucine-rich repeat	168..214	CDD:275380	17/45 (38%)
		LRR_RI	<202..424	CDD:238064	80/247 (32%)
		LRR_8	213..271	CDD:290566	22/57 (39%)
		leucine-rich repeat	215..237	CDD:275380	7/21 (33%)
		leucine-rich repeat	238..260	CDD:275380	10/21 (48%)
		LRR_8	259..316	CDD:290566	23/58 (40%)
		leucine-rich repeat	261..282	CDD:275380	7/22 (32%)
		leucine-rich repeat	306..359	CDD:275380	19/65 (29%)
		LRR_RI	358..562	CDD:238064	25/99 (25%)
		leucine-rich repeat	367..388	CDD:275380	7/20 (35%)
		leucine-rich repeat	389..411	CDD:275380	5/30 (17%)
		LRR_8	411..468	CDD:290566	10/35 (29%)
		leucine-rich repeat	412..435	CDD:275380	6/22 (27%)
		leucine-rich repeat	436..459	CDD:275380	3/10 (30%)
		leucine-rich repeat	460..483	CDD:275380
		leucine-rich repeat	484..506	CDD:275380
		LRR_8	505..564	CDD:290566
		leucine-rich repeat	507..529	CDD:275380
		leucine-rich repeat	530..553	CDD:275380
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm3538
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910