DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment scrib and AT3G17920

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	NP_188419.2	Gene:	AT3G17920 / 819843	AraportID:	AT3G17920	Length:	1010	Species:	Arabidopsis thaliana

Alignment Length:	888	Identity:	196/888 - (22%)
Similarity:	312/888 - (35%)	Gaps:	231/888 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 EEILRYSRTLEELFLDANHIRDL-PKNF----FRLHRLRKL-----GLSDNEIGRLPPDIQNFEN 84
            |.:.|:.....:|.:|...:..| |...    .||..||:|     |...:.:.....||.:|..
plant    11 ENLQRFLDEKADLLIDGTDVLKLNPAGLHYVHLRLESLRELELMLSGAPVDYLRAYVSDIGDFRA 75

  Fly    85 LVELDVSRNDIPDIPDDIKHLQSLQVADFSSNPIPKLPSGFSQLKNLTVLGLNDMSLTTLPADFG 149
            |.:|   |..:..:| .:|.:.||........|:..||  ||:||   ||.|....|:|..|.
plant    76 LEQL---RRILRLLP-SLKVVSSLPSPARDPTPLSLLP--FSKLK---VLELRGCDLSTSSAK-- 129

  Fly   150 SLTQLESLELR---ENLLKHLPETISQLTKLKRLDLGDNEIEDLPPYLGYLPGLHELWLDHNQLQ 211
                 ..||||   |.|:.|......:.....|:    .||:|.|.:
plant   130 -----GLLELRHTLEKLICHNSTDALRHVFASRI----AEIKDSPQW------------------ 167

  Fly   212 RLPPELGLLTKLTYLDVSENRLEELPNEISGLVSLTDLDLAQNLLEALPDGIAKLSRLTILKLDQ 276
                     .||.::..:.|||..:...:..|.::..|||::|.. |..|.:.:.::|..|.|..
plant   168 ---------NKLAFISCACNRLVLMDESLQLLPAVESLDLSRNKF-AKVDNLRRCNKLKHLDLGF 222

  Fly   277 NRLQRLNDTLGNCENMQELILTENFLSELPASIGQMTKLNNLNVDRNAL-EYLPLEIGQCANLGV 340
            |:|::::.......::.:|:|..|.|:.| ..|..:..|..|:|..|.: ::..||.     ||.
plant   223 NQLRKISHLSEVSCHLVKLVLRNNALTTL-RGIENLKSLEGLDVSFNLISDFSELEF-----LGS 281

  Fly   341 LS-LRDNKLKKLPPELGNCTVLHVLDVSGNQLLYLPYSL----VNLQLKAVW-----LSENQSQP 395
            || |.|..|:..|.........|||     ..:|||..|    .::..:..|     ::..:|||
plant   282 LSFLTDLWLEGNPICCARWYRAHVL-----SYVYLPNDLKLDGKHIGNREFWKRQVVVTRRKSQP 341

  Fly   396 LLTFQPDTDAETGEQVLSCYLLPQQEYQPITPARDLESDSE--------------PFEEREPSRT 446
                                    ..|...:|||| |:|.|              ..:..|.|..
plant   342 ------------------------ASYGFYSPARD-EADDEGSFTRKKTKIYRLASIDSEEESTY 381

  Fly   447 VVKFSEEATQEKETPFVRQN--TPHPKD---LKAKAQKLKVERS--RNEEHANLVTLPEE----- 499
            |....|.|:.|.||....:|  :.|..|   |..|.::||.|||  ...|....:..|.|
plant   382 VNSDQESASCEPETQSKEENIKSDHEADVFGLICKVEQLKKERSVLWLREFKEWIDHPSEDFVDV 446

  Fly   500 --NGTKLAETPTETRTIANNHQQQPH--------PVQQP---IVGVNSKQPVVVGVVTP----TT 547
              ||   :.|.:|.:....|.....|        |...|   |..:|.|.........|    ..
plant   447 SKNG---SSTDSEQKYYMKNRNGPKHHGETMRYTPGPLPSFQITDLNQKHQAFFLDGKPDENGNM 508

  Fly   548 TTVAPTGVQGGSEGASSTAN---NVKAATAAVVAEL------AATVGGSDEVQDDDEQEDEFESD 603
            :|:..:....||...||..:   :|......:|.|:      :.:|..||....::|..|..:|:
plant   509 STLDASQDMTGSFSPSSPPHYQKDVLHRRQNLVEEILQISADSYSVASSDSSCSENENYDSEQSN 573

  Fly   604 RRVGFQVEGEDDDFYKRPPKLHRRDTPHHLKNKRVQ--HLTDKQASEILANALASQERNDTTPQH 666
                     .:.|..|           .||...|.:  .|.|.|..:  ::.:.|.:..|
plant   574 ---------PEQDTLK-----------DHLSGNRGEDTSLLDSQPEK--SSIIKSWKIED----- 611

  Fly   667 SLSGKVTSPIEEEEQLEVEQEQQQ--------QQQQHPFDSSLSP------ISAGKTAEASTDPD 717
            |...|.|:.:....:.|:.....|        |.::.|...::||      |..|:|:..| |.|
plant   612 SFKAKTTNFLSGLHKSELASGVNQIYRWFDKKQSKRKPKKRNVSPLEEYSFIKKGETSHRS-DAD 675

  Fly   718 NLDGVTELRLEQYEIHIERTAAGLGLSIAGGKGSTPFKGDDDGIFISRVTEAGPADLAGLKVGDK 782
            .:|...:   |....|.:..:...|   ...|.||.|          ..||.....:.||
plant   676 IIDSCED---EYISDHFQEGSLTTG---CNSKRSTRF----------LETEKSLEGMGGL----- 719

  Fly   783 VIKVNGIVVVDADHYQAVQVLKACGAVL---VLVVQREVTRLI 822
            |.:.....:.|:.:.:..::..:|..:|   ....||||..|:
plant   720 VEEFFTTTLSDSSNDETCRIYVSCDCILQQESTYKQREVVLLL 762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064	64/265 (24%)
		leucine-rich repeat	18..38	CDD:275380	2/7 (29%)
		LRR_8	37..95	CDD:290566	16/67 (24%)
		leucine-rich repeat	39..61	CDD:275380	6/26 (23%)
		leucine-rich repeat	62..84	CDD:275380	7/26 (27%)
		LRR_8	84..138	CDD:290566	17/53 (32%)
		leucine-rich repeat	85..107	CDD:275380	5/21 (24%)
		leucine-rich repeat	108..130	CDD:275380	7/21 (33%)
		LRR_8	129..187	CDD:290566	15/60 (25%)
		leucine-rich repeat	131..153	CDD:275380	6/21 (29%)
		leucine-rich repeat	154..176	CDD:275380	7/24 (29%)
		leucine-rich repeat	177..199	CDD:275380	5/21 (24%)
		LRR_8	198..256	CDD:290566	10/57 (18%)
		leucine-rich repeat	200..222	CDD:275380	0/21 (0%)
		leucine-rich repeat	223..245	CDD:275380	5/21 (24%)
		LRR_8	267..325	CDD:290566	15/57 (26%)
		leucine-rich repeat	269..289	CDD:275380	5/19 (26%)
		leucine-rich repeat	292..314	CDD:275380	6/21 (29%)
		leucine-rich repeat	315..337	CDD:275380	6/22 (27%)
		LRR_4	337..375	CDD:289563	12/38 (32%)
		leucine-rich repeat	361..382	CDD:275380	7/24 (29%)
		PDZ	728..816	CDD:214570	15/90 (17%)
		PDZ_signaling	931..1016	CDD:238492
		PDZ	1239..1329	CDD:214570
		PDZ_signaling	1336..1425	CDD:238492
AT3G17920	NP_188419.2	leucine-rich repeat	51..78	CDD:275380	6/26 (23%)
		leucine-rich repeat	79..112	CDD:275380	10/38 (26%)
		leucine-rich repeat	113..136	CDD:275378	11/32 (34%)
		LRR_RI	<189..297	CDD:238064	32/114 (28%)
		leucine-rich repeat	193..214	CDD:275378	6/21 (29%)
		leucine-rich repeat	215..237	CDD:275378	5/21 (24%)
		LRR_8	237..295	CDD:290566	19/63 (30%)
		leucine-rich repeat	238..259	CDD:275378	6/21 (29%)
		leucine-rich repeat	260..284	CDD:275378	9/28 (32%)
		leucine-rich repeat	285..297	CDD:275378	4/11 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910