DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment scrib and RLP32

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	NP_187216.1	Gene:	RLP32 / 819732	AraportID:	AT3G05650	Length:	868	Species:	Arabidopsis thaliana

Alignment Length:	580	Identity:	125/580 - (21%)
Similarity:	191/580 - (32%)	Gaps:	258/580 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 LEELFLDANHIRDL-PKNFFRLHRLRKLGLSDNEI-GRLPPDIQNFEN----------------- 84
            |..|::|:|.:..: |.:...|..|..|.||.|:. |.||.::.:..|
plant   192 LTNLYVDSNDLTGIFPLSLLNLKHLSDLSLSRNQFTGTLPSNMSSLSNLEYFEAWGNAFTGTLPS 256

  Fly    85 -------LVELDVSRNDIPDIPD--DIKHLQSLQVADFSSN----PIPKLPSGFSQLKNLTVLGL 136
                   |..:::..|.:....:  :|....:|.|.|.|:|    ||||..|.|..|::|.:..|
plant   257 SLFTIASLTSINLRNNQLNGTLEFGNISSPSTLTVLDISNNNFIGPIPKSISKFINLQDLDLSHL 321

  Fly   137 NDMSLTTLPADFGSLTQLESLELRENLLKHL---------------------------------- 167
            |    |..|.||...|.|:||:|..  |.||
plant   322 N----TQGPVDFSIFTNLKSLQLLN--LSHLNTTTTIDLNALFSSHLNSIYSMDLSGNHVSATTK 380

  Fly   168 -------------------------PETISQLTKLKRLDLGDNEIE-DLPPYLGYLPGL------ 200
                                     ||.:....|:..||:.:|:|: .:|.:|..||.|
plant   381 ISVADHHPTQLISQLYLSGCGITEFPELLRSQHKMTNLDISNNKIKGQVPGWLWTLPKLIFVDLS 445

  Fly   201 ------------HELWL------------------------------------DHNQLQRLPPEL 217
                        |.|.|                                    |:|....:||.:
plant   446 NNIFTGFERSTEHGLSLITKPSMQYLVGSNNNFTGKIPSFICALRSLITLDLSDNNLNGSIPPCM 510

  Fly   218 G-LLTKLTYLDVSENRL-EELPNEISGLVSLTDLDLAQN-LLEALPDGIAKLSRLTILKLDQNRL 279
            | |.:.|::|::.:||| ..||..|  ..||..||:..| |:..||....:||.|.:|.::.|
plant   511 GNLKSTLSFLNLRQNRLGGGLPRSI--FKSLRSLDVGHNQLVGKLPRSFIRLSALEVLNVENN-- 571

  Fly   280 QRLNDT----LGNCENMQELIL------------------------------------------- 297
             |:|||    |.:.:.:|.|:|
plant   572 -RINDTFPFWLSSLKKLQVLVLRSNAFHGPIHHASFHTLRIINLSHNQFSGTLPANYFVNWNAMS 635

  Fly   298 ------------------------------------------------TENFL-SELPASIGQMT 313
                                                            :||.| .|:|.|||.:.
plant   636 SLMATEDRSQEKYMGDSFRYYHDSVVLMNKGLEMELVRILKIYTALDFSENKLEGEIPRSIGLLK 700

  Fly   314 KLNNLNVDRNALE-YLPLEIGQCANLGVLSLRDNKLK-KLPPELGNCTVLHVLDVSGNQL 371
            :|:.||:..||.. ::|..:|....|..|.:..|||. ::|.||||.:.|..::.|.|||
plant   701 ELHVLNLSSNAFTGHIPSSMGNLRELESLDVSQNKLSGEIPQELGNLSYLAYMNFSHNQL 760

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064	88/392 (22%)
		leucine-rich repeat	18..38	CDD:275380
		LRR_8	37..95	CDD:290566	17/81 (21%)
		leucine-rich repeat	39..61	CDD:275380	6/22 (27%)
		leucine-rich repeat	62..84	CDD:275380	8/22 (36%)
		LRR_8	84..138	CDD:290566	18/83 (22%)
		leucine-rich repeat	85..107	CDD:275380	3/23 (13%)
		leucine-rich repeat	108..130	CDD:275380	12/25 (48%)
		LRR_8	129..187	CDD:290566	21/116 (18%)
		leucine-rich repeat	131..153	CDD:275380	7/21 (33%)
		leucine-rich repeat	154..176	CDD:275380	9/80 (11%)
		leucine-rich repeat	177..199	CDD:275380	7/22 (32%)
		LRR_8	198..256	CDD:290566	24/114 (21%)
		leucine-rich repeat	200..222	CDD:275380	10/76 (13%)
		leucine-rich repeat	223..245	CDD:275380	8/22 (36%)
		LRR_8	267..325	CDD:290566	24/153 (16%)
		leucine-rich repeat	269..289	CDD:275380	8/23 (35%)
		leucine-rich repeat	292..314	CDD:275380	11/113 (10%)
		leucine-rich repeat	315..337	CDD:275380	7/22 (32%)
		LRR_4	337..375	CDD:289563	15/36 (42%)
		leucine-rich repeat	361..382	CDD:275380	5/11 (45%)
		PDZ	728..816	CDD:214570
		PDZ_signaling	931..1016	CDD:238492
		PDZ	1239..1329	CDD:214570
		PDZ_signaling	1336..1425	CDD:238492
RLP32	NP_187216.1	LRRNT_2	42..86	CDD:311940
		PLN00113	70..>787	CDD:331614	125/580 (22%)
		leucine-rich repeat	121..144	CDD:275380
		leucine-rich repeat	145..168	CDD:275380
		leucine-rich repeat	169..191	CDD:275380
		leucine-rich repeat	192..215	CDD:275380	6/22 (27%)
		leucine-rich repeat	216..263	CDD:275380	9/46 (20%)
		leucine-rich repeat	264..288	CDD:275380	3/23 (13%)
		leucine-rich repeat	289..312	CDD:275380	11/22 (50%)
		leucine-rich repeat	313..337	CDD:275380	10/27 (37%)
		leucine-rich repeat	367..390	CDD:275380	0/22 (0%)
		leucine-rich repeat	391..414	CDD:275380	2/22 (9%)
		leucine-rich repeat	415..438	CDD:275380	7/22 (32%)
		leucine-rich repeat	439..467	CDD:275380	4/27 (15%)
		leucine-rich repeat	468..491	CDD:275380	0/22 (0%)
		leucine-rich repeat	492..515	CDD:275380	6/22 (27%)
		leucine-rich repeat	517..538	CDD:275380	8/22 (36%)
		leucine-rich repeat	539..562	CDD:275380	8/22 (36%)
		leucine-rich repeat	563..586	CDD:275380	8/25 (32%)
		leucine-rich repeat	609..636	CDD:275380	0/26 (0%)
		leucine-rich repeat	637..701	CDD:275380	8/63 (13%)
		leucine-rich repeat	702..725	CDD:275380	7/22 (32%)
		leucine-rich repeat	726..749	CDD:275380	10/22 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910