DRSC/TRiP Functional Genomics Resources

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Protein Alignment scrib and TLR10

DIOPT Version :9

Sequence 1:NP_001163746.1 Gene:scrib / 44448 FlyBaseID:FBgn0263289 Length:2585 Species:Drosophila melanogaster
Sequence 2:NP_001017388.1 Gene:TLR10 / 81793 HGNCID:15634 Length:811 Species:Homo sapiens


Alignment Length:489 Identity:103/489 - (21%)
Similarity:185/489 - (37%) Gaps:155/489 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    78 DIQNFENLVELDVSRNDIPDI--PDDIKHLQSLQVADFSSNPI-PKLPSGFSQLKNLTVLGLNDM 139
            ||:|      |.:|...:|.:  |:   :....|..:|::|.: .:|.....||.:|..|.||..
Human   327 DIEN------LTISNAQMPHMLFPN---YPTKFQYLNFANNILTDELFKRTIQLPHLKTLILNGN 382

  Fly   140 SLTTLP--ADFGSLTQLESLELRENLLKH-------LPETISQLTKLKRLDLGDNEIEDLPPYLG 195
            .|.||.  :.|.:.|.||.|:|.:|||:|       .|||:      ..::|..|::.|      
Human   383 KLETLSLVSCFANNTPLEHLDLSQNLLQHKNDENCSWPETV------VNMNLSYNKLSD------ 435

  Fly   196 YLPGLHELWLDHNQLQRLPPELGLLTKLTYLDVSENRLEELPNEISGLVSLTDLDLAQNLLEALP 260
                        :..:.||..:.:      ||::.|:::.:|.|...|::|.:|::|.|.|..||
Human   436 ------------SVFRCLPKSIQI------LDLNNNQIQTVPKETIHLMALRELNIAFNFLTDLP 482

  Fly   261 DGIAKLSRLTILKLDQNRLQRLNDTLGNCENMQELILTENFLSELPASIGQMTKLNNLNVDRNAL 325
             |.:..|||::|.::.|.:  |:.:|...::.||                    :..||..||..
Human   483 -GCSHFSRLSVLNIEMNFI--LSPSLDFVQSCQE--------------------VKTLNAGRNPF 524

  Fly   326 -------EYLPLE-IGQCANLG---------VLSLRDNKLKKLPPELGNC-------TVLHVLDV 366
                   .::.|| ..:...:|         .|:||..:||.:.....:|       |::.::.|
Human   525 RCTCELKNFIQLETYSEVMMVGWSDSYTCEYPLNLRGTRLKDVHLHELSCNTALLIVTIVVIMLV 589

  Fly   367 SGNQLLY------LPYSLVNL-QLKAVW-----LSENQSQPLLTFQ------------------P 401
            .|..:.:      ||:.|..| |....|     .::.|.:..:.|.                  |
Human   590 LGLAVAFCCLHFDLPWYLRMLGQCTQTWHRVRKTTQEQLKRNVRFHAFISYSEHDSLWVKNELIP 654

  Fly   402 DTDAETGEQVLSCYLLPQQEYQPITPARDLESDSEPFEEREPSRTVVKFSEEATQEK----ETPF 462
            :.:.|.|..::..|    :.|  ..|.:.:..:...|.|:. .:::...|....|.:    |..|
Human   655 NLEKEDGSILICLY----ESY--FDPGKSISENIVSFIEKS-YKSIFVLSPNFVQNEWCHYEFYF 712

  Fly   463 VRQNTPHPKDLKAKAQKLKVERSRNEEHANLVTL 496
            ...|..|                .|.:|..|:.|
Human   713 AHHNLFH----------------ENSDHIILILL 730

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
scribNP_001163746.1 LRR_RI 13..283 CDD:238064 57/216 (26%)
leucine-rich repeat 18..38 CDD:275380
LRR_8 37..95 CDD:290566 5/16 (31%)
leucine-rich repeat 39..61 CDD:275380
leucine-rich repeat 62..84 CDD:275380 3/5 (60%)
LRR_8 84..138 CDD:290566 13/56 (23%)
leucine-rich repeat 85..107 CDD:275380 4/23 (17%)
leucine-rich repeat 108..130 CDD:275380 6/22 (27%)
LRR_8 129..187 CDD:290566 22/66 (33%)
leucine-rich repeat 131..153 CDD:275380 8/23 (35%)
leucine-rich repeat 154..176 CDD:275380 11/28 (39%)
leucine-rich repeat 177..199 CDD:275380 3/21 (14%)
LRR_8 198..256 CDD:290566 12/57 (21%)
leucine-rich repeat 200..222 CDD:275380 2/21 (10%)
leucine-rich repeat 223..245 CDD:275380 6/21 (29%)
LRR_8 267..325 CDD:290566 13/57 (23%)
leucine-rich repeat 269..289 CDD:275380 5/19 (26%)
leucine-rich repeat 292..314 CDD:275380 2/21 (10%)
leucine-rich repeat 315..337 CDD:275380 6/29 (21%)
LRR_4 337..375 CDD:289563 10/59 (17%)
leucine-rich repeat 361..382 CDD:275380 6/27 (22%)
PDZ 728..816 CDD:214570
PDZ_signaling 931..1016 CDD:238492
PDZ 1239..1329 CDD:214570
PDZ_signaling 1336..1425 CDD:238492
TLR10NP_001017388.1 LRR 1 24..46
LRR 2 49..70
leucine-rich repeat 50..73 CDD:275378
LRR_8 72..129 CDD:316378
LRR 3 73..94
leucine-rich repeat 74..97 CDD:275378
LRR 4 97..118
leucine-rich repeat 98..112 CDD:275378
leucine-rich repeat 119..143 CDD:275378
LRR 5 119..139
LRR 6 143..166
leucine-rich repeat 144..155 CDD:275378
LRR 289..>522 CDD:227223 63/256 (25%)
LRR 7 296..321
LRR 8 325..348 7/29 (24%)
LRR 9 349..368 4/18 (22%)
leucine-rich repeat 350..373 CDD:275380 6/22 (27%)
LRR 10 373..394 7/20 (35%)
leucine-rich repeat 374..398 CDD:275380 8/23 (35%)
LRR 11 398..419 8/20 (40%)
leucine-rich repeat 399..422 CDD:275380 9/22 (41%)
LRR 12 422..442 4/43 (9%)
leucine-rich repeat 423..444 CDD:275380 5/44 (11%)
LRR 13 444..465 5/26 (19%)
leucine-rich repeat 445..467 CDD:275380 6/27 (22%)
LRR 14 467..488 8/21 (38%)
leucine-rich repeat 468..490 CDD:275380 9/22 (41%)
LRR 15 489..509 6/21 (29%)
leucine-rich repeat 491..513 CDD:275380 4/23 (17%)
LRRCT 522..574 CDD:214507 9/51 (18%)
TIR 633..775 CDD:214587 19/121 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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