DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scrib and Snx27

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	NP_001075953.1	Gene:	Snx27 / 76742	MGIID:	1923992	Length:	539	Species:	Mus musculus

Alignment Length:	612	Identity:	128/612 - (20%)
Similarity:	203/612 - (33%)	Gaps:	194/612 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly  1240 VVLPKNQGSLGFSIIG----GTDHSCVPFGTREPGIFISHIVPGGIASKCGKLRMGDRILKVNEA 1300
            |.:.|::...||::.|    |.....:......|...:|.::|||.|.:.| :|.|||||:||..
Mouse    42 VRIVKSESGYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAADRAG-VRKGDRILEVNGV 105

  Fly  1301 DVSKATHQDAVLELLKPGD-EIKLTIQHDPLPPGFQEVLLSKAEGERLGMHIKGGLNGQRGNPAD 1364
            :|..|||:. |::|::.|: |:.||:.  .:||         .|.:.|                |
Mouse   106 NVEGATHKQ-VVDLIRAGEKELILTVL--SVPP---------HEADNL----------------D 142

  Fly  1365 PSDEGVFVSKINSVGAARRDGRLKVGMRL-------LEVNGHSLLGASHQDAVNVLRNAGNEIQL 1422
            |||:        |:|.:..|...|..:.:       :|.||...:      ..||.. ||.::
Mouse   143 PSDD--------SLGQSFYDYTEKQAVPISVPTYKHVEQNGEKFV------VYNVYM-AGRQL-- 190

  Fly  1423 VVC-KGYDKSNLIHSIGQAGGMSTGF-NSSASCSGG------SRQGSRASETGSE---------- 1469
              | |.|.:..::|.     .:...| |.:.....|      |.|...|...|.|
Mouse   191 --CSKRYREFAILHQ-----NLKREFANFTFPRLPGKWPFSLSEQQLDARRRGLEEYLEKVCSIR 248

  Fly  1470 -LSQSQSVSSLDHEEDERLRQDFDV-FASQKPDA--------QQPTGPSVLAAAAAMVHGASSPT 1524
             :.:|..:.....|.||......|| .....||.        :..|...|..|.||.| |..|.|
Mouse   249 VIGESDIMQEFLSESDENYNGVSDVELRVALPDGTTVTVRVKKNSTTDQVYQAIAAKV-GMDSTT 312

  Fly  1525 ----------PPAATSNITP--LPTAAAVASADLTAPDTPATQTVALIHAEQQA----------- 1566
                      ..:....:.|  .|....|.:.....|.|..|....|...|::.
Mouse   313 VNYFALFEVINHSFVRKLAPNEFPHKLYVQNYTSAVPGTCLTIRKWLFTTEEEVLLNDNDLAVTY 377

  Fly  1567 --HQQQQQTQLAPL-GQEKSTQEKVLEIVRAADAFTTVPPKSPSEHHEQDKIQKTTTVVISKHTL 1628
              ||.....:...: .:|||.|.:.|                    |||.|      :|:..:.|
Mouse   378 FFHQAVDDVKKGYIKAEEKSYQLQKL--------------------HEQRK------MVMYLNML 416

  Fly  1629 DTNPTTPTTPAAPLSIAGAESANSAGAPSPAVPASTPGSAPVLPAVAV------------QTQTQ 1681
            .|                .|..|....|..|..:...|.  |:.|:::            |.:.|
Mouse   417 RT----------------CEGYNEIIFPHCACDSRRKGH--VITAISITHFKLHACTEEGQLENQ 463

  Fly  1682 TTSTEKDEEEESQLQSTPASRDGAEEQQEEVRAKPTPTKVPKSVSDKKRFFESAMEDQHKPTQKT 1746
            ..:.|.||     :|......:|.....|..|.:..|..|        :.|.......|   :..
Mouse   464 VIAFEWDE-----MQRWDTDEEGMAFCFEYARGEKKPRWV--------KIFTPYFNYMH---ECF 512

  Fly  1747 DKVFSFLS--KDEVEKLRQEEERKIAT 1771
            ::||..|.  |:.:.::.:.::|.:||
Mouse   513 ERVFCELKWRKENIFQMARSQQRDVAT 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064
		leucine-rich repeat	18..38	CDD:275380
		LRR_8	37..95	CDD:290566
		leucine-rich repeat	39..61	CDD:275380
		leucine-rich repeat	62..84	CDD:275380
		LRR_8	84..138	CDD:290566
		leucine-rich repeat	85..107	CDD:275380
		leucine-rich repeat	108..130	CDD:275380
		LRR_8	129..187	CDD:290566
		leucine-rich repeat	131..153	CDD:275380
		leucine-rich repeat	154..176	CDD:275380
		leucine-rich repeat	177..199	CDD:275380
		LRR_8	198..256	CDD:290566
		leucine-rich repeat	200..222	CDD:275380
		leucine-rich repeat	223..245	CDD:275380
		LRR_8	267..325	CDD:290566
		leucine-rich repeat	269..289	CDD:275380
		leucine-rich repeat	292..314	CDD:275380
		leucine-rich repeat	315..337	CDD:275380
		LRR_4	337..375	CDD:289563
		leucine-rich repeat	361..382	CDD:275380
		PDZ	728..816	CDD:214570
		PDZ_signaling	931..1016	CDD:238492
		PDZ	1239..1329	CDD:214570	31/93 (33%)
		PDZ_signaling	1336..1425	CDD:238492	17/95 (18%)
Snx27	NP_001075953.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..40
		PDZ_signaling	39..131	CDD:238492	31/90 (34%)
		PX_SNX27	158..263	CDD:132796	21/120 (18%)
		FERM-like region F1. /evidence=ECO:0000250	271..360		19/89 (21%)
		SNX27_RA	272..358	CDD:176372	19/86 (22%)
		FERM-like region F2. /evidence=ECO:0000250	371..419		14/89 (16%)
		FERM-like_C_SNX27	423..524	CDD:270146	22/118 (19%)
		FERM-like region F3. /evidence=ECO:0000250	423..523		22/117 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910