DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scrib and Grip1

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	XP_006514294.1	Gene:	Grip1 / 74053	MGIID:	1921303	Length:	1185	Species:	Mus musculus

Alignment Length:	1256	Identity:	259/1256 - (20%)
Similarity:	418/1256 - (33%)	Gaps:	412/1256 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   674 SPIEEEEQ---LEVEQEQQQQ-----------------QQQHPFDSSLS---PISAGKTAEASTD 715
            ||::..||   :...:||:.:                 :.:.|:..|.|   |..........:.
Mouse    37 SPLQPPEQSPCVHFAREQRARMIAVSFKCRCQILRRLTKDESPYTKSASQTKPPDGALAVRRQSI 101

  Fly   716 PDNLDGVTELRLEQYEIHIERTAAGLGLSIAGGKGSTPFKGDDDG-IFISRVTEAGPADLAG-LK 778
            |:...|.|.:.|      :::....|||:::||.       |.|| ..:|.:.:.|.|..:. |.
Mouse   102 PEEFKGSTVVEL------MKKEGTTLGLTVSGGI-------DKDGKPRVSNLRQGGIAARSDQLD 153

  Fly   779 VGDKVIKVNGIVVVDADHYQAVQVLKACGAVLVLVVQREVTRLIGHPVFSEDGSVSQISVE---- 839
            |||.:..||||.:....|.:.:.:||..|..:||.|:.|:.     ||..:..||...:||
Mouse   154 VGDYIKAVNGINLAKFRHDEIISLLKNVGERVVLEVEYELP-----PVSVQGSSVMFRTVEVTLH 213

  Fly   840 --------------------TRPLVADAPPAASISHERYIPAPIE--IVPQQQHLQQQQQQPIQQ 882
                                :||:|........       ||..|  |.|..:.|   ....|:.
Mouse   214 KEGNTFGFVIRGGAHDDRNKSRPVVITCVRPGG-------PADREGTIKPGDRLL---SVDGIRL 268

  Fly   883 VAPTHSYSGNVFATPTAAQT--------VQPAVSAAPNGLLLNGREAPLSYIQLHTTLIRDQIGQ 939
            :..||:.:.::........|        |..:|:.|...||:...:.|.:           .:|.
Mouse   269 LGTTHAEAMSILKQCGQEATLLIEYDVSVMDSVATASGPLLVEVAKTPGA-----------SLGV 322

  Fly   940 GLGFSIAGGKGSPPFKDDCDGIFISRITEGGLAYRDGKIMVGDRVMAINGNDM---TEAHHDAAV 1001
            .|..|:...|         ..|.|.:|....:|.|.|.:.|||.:::|:|..|   |.|.....:
Mouse   323 ALTTSVCCNK---------QVIVIDKIKSASIADRCGALHVGDHILSIDGTSMEYCTLAEATQFL 378

  Fly  1002 ACLTE-------PQRFVRLVL--------QREYR-GPLE-------------------------- 1024
            |..|:       |....||.|        ||..| .|.:
Mouse   379 ANTTDQVKLEILPHHQTRLALKGPDHVKIQRSDRQHPWDAWASNQCGVHTNHHHNTYHPDHCRVP 443

  Fly  1025 --------PPTSPRSPAVLNSLSPSGYLANRPANFSRSVVEVEQPYKYNTLATTTPTPKPTVPAS 1081
                    ||.||  ||::.|.||:...|                |..::|
Mouse   444 ALTFPKALPPNSP--PAMVPSSSPTSMSA----------------YSLSSL-------------- 476

  Fly  1082 ISNNNNTLPSS---------------KTNGFATA---AAATIDSSTGQPVPAPRRTNSVPMGDGD 1128
               |..|||.|               |...|.::   |::|: ...||.|.. ..|..|...|..
Mouse   477 ---NMGTLPRSLYSTSPRGTMMRRRLKKKDFKSSLSLASSTV-GLAGQVVHT-ETTEVVLTADPV 536

  Fly  1129 IGAGSTTSGDSGEAQPSSLRPLTSDDFQAMIPAHFLSGGSQHQVHVARPNE------VGVSAVTV 1187
            .|.|....|.....:..|..||.|                  .:....|.|      :|...:.:
Mouse   537 TGFGIQLQGSVFATETLSSPPLIS------------------YIEADSPAERCGVLQIGDRVMAI 583

  Fly  1188 NVNKPQPDLPMFPAAPTELGRVTETITKSTFTE--------TVMTRIT---DNQLAEPLISE--- 1238
            |            ..|||         .|||.|        ::.:::|   :..:||.:|..
Mouse   584 N------------GIPTE---------DSTFEEANQLLRDSSITSKVTLEIEFDVAESVIPSSGT 627

  Fly  1239 -EVVLPKNQG-SLGFSIIGGTDHSCVPFGTREPG--IFISHIVPGGIASKCGKLRMGDRILKVNE 1299
             .|.|||... .||.:|...:        :|:||  :.||.|..|.:|.:.|.|.:||::|.::.
Mouse   628 FHVKLPKKHSVELGITISSPS--------SRKPGDPLVISDIKKGSVAHRTGTLELGDKLLAIDN 684

  Fly  1300 ADVSKATHQDAVLELLKPGDEIKLTIQHDPLPPGFQE-------VLLSKAEGERLGMHIKGGLNG 1357
            ..:...:.:|||..|.:..|.:||.|:.|......||       .:..|..|..||:.|.|
Mouse   685 IRLDNCSMEDAVQILQQCEDLVKLKIRKDEDNSDEQESSGAIIYTVELKRYGGPLGITISG---- 745

  Fly  1358 QRGNPADPSDEGVFVSKINSVGAARRDGRLKVGMRLLEVNGHSLLGASHQDAVNVLRNAGNEIQL 1422
             ...|.||    :.:|.:...|.|.|.|.:.:|.|:|.:|..||.|....:|:::|:.||..:.|
Mouse   746 -TEEPFDP----IIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQMAGETVTL 805

  Fly  1423 VVCKGYDKSNLIHSIGQAGGMSTGFNSSASCSGGSRQGSRASETGSELSQSQSVSSLDHEEDERL 1487
            .:.|..|.                  .|||..........:.:.|            |.|||..
Mouse   806 KIKKQTDA------------------QSASSPKKFPIPGHSGDLG------------DGEEDPS- 839

  Fly  1488 RQDFDVFASQKP----DAQQPTGPSVLAAAAA-------MVHGASSPT--------------PPA 1527
                   ..|||    ||...|.|||.:|..:       ..:|:...|              .|.
Mouse   840 -------PIQKPGKLSDAYPSTVPSVDSAVDSWDGSGIDASYGSQGSTFQTSGYNYNTYDWRSPK 897

  Fly  1528 ATSNITPLPTAAAVASAD--LTAPDTPATQTVALIHAEQQAHQQQQQTQLAPLGQEKST--QEKV 1588
            ..::::|:|...:....|  |:..|...:.....:.|...|..:|::...:...::..|  |..:
Mouse   898 QRTSLSPVPKPRSQTYPDVGLSNEDWDRSTASGFVGASDSADAEQEENFWSQALEDLETCGQSGI 962

  Fly  1589 L-EIVRAADAFTTVPPKSPSEHHEQDKIQKTTTVVISKHTLDTNPTTPTTPAAPLSIAGAESANS 1652
            | |:...||...::            :.......::|..|:..|   ...|.|...:....|...
Mouse   963 LRELEEKADRRVSL------------RNMTLLATIMSGSTMSLN---HEAPMARSQLGRQASFQE 1012

  Fly  1653 AGAPSPAVPASTPGSAPVLPAVAVQTQTQTTSTEKDEEEESQLQSTPASRDGAEEQQEEVRAKPT 1717
            ..:..|....:|..:  .||:   ....::.:..|.::|..::.|                  ||
Mouse  1013 RSSSRPHYSQTTRSN--TLPS---DVGRKSVTLRKMKQEIKEIMS------------------PT 1054

  Fly  1718 PTKVPKSVSDKKRFFESAMED 1738
            |.::.|....|    :|.|||
Mouse  1055 PVELHKVTLYK----DSGMED 1071

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064
		leucine-rich repeat	18..38	CDD:275380
		LRR_8	37..95	CDD:290566
		leucine-rich repeat	39..61	CDD:275380
		leucine-rich repeat	62..84	CDD:275380
		LRR_8	84..138	CDD:290566
		leucine-rich repeat	85..107	CDD:275380
		leucine-rich repeat	108..130	CDD:275380
		LRR_8	129..187	CDD:290566
		leucine-rich repeat	131..153	CDD:275380
		leucine-rich repeat	154..176	CDD:275380
		leucine-rich repeat	177..199	CDD:275380
		LRR_8	198..256	CDD:290566
		leucine-rich repeat	200..222	CDD:275380
		leucine-rich repeat	223..245	CDD:275380
		LRR_8	267..325	CDD:290566
		leucine-rich repeat	269..289	CDD:275380
		leucine-rich repeat	292..314	CDD:275380
		leucine-rich repeat	315..337	CDD:275380
		LRR_4	337..375	CDD:289563
		leucine-rich repeat	361..382	CDD:275380
		PDZ	728..816	CDD:214570	26/89 (29%)
		PDZ_signaling	931..1016	CDD:238492	24/102 (24%)
		PDZ	1239..1329	CDD:214570	28/92 (30%)
		PDZ_signaling	1336..1425	CDD:238492	27/95 (28%)
Grip1	XP_006514294.1	PDZ_signaling	110..190	CDD:238492	26/92 (28%)
		PDZ_signaling	209..292	CDD:238492	14/92 (15%)
		PDZ_signaling	307..390	CDD:238492	23/102 (23%)
		PDZ_signaling	526..614	CDD:238492	22/126 (17%)
		PDZ_signaling	627..711	CDD:238492	27/91 (30%)
		PDZ_signaling	727..808	CDD:238492	26/89 (29%)
		PDZ_signaling	1058..1138	CDD:238492	6/18 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910