DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scrib and Whrn

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	NP_001008791.1	Gene:	Whrn / 73750	MGIID:	2682003	Length:	918	Species:	Mus musculus

Alignment Length:	886	Identity:	183/886 - (20%)
Similarity:	294/886 - (33%)	Gaps:	352/886 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly  1127 GDIGAGSTTSGDSGEAQPSSLRPLTSDDFQAMIPAHFLSGGSQHQVHVARPNEVGVSAVTVNVNK 1191
            |.:|:.:..:|..|.|   .||.|::               :..|:|         .|:|..:::
Mouse    16 GSLGSAAAAAGGGGGA---GLRLLSA---------------NVRQLH---------QALTALLSE 53

  Fly  1192 PQPD-----LPMFPAAPT--ELGRVTETITKSTFTETVMTRI------TDNQLAEPLISEEVVLP 1243
            |:.:     |..:.|...  :|.|....:..|.....::..:      :|..|.:...:|.:.||
Mouse    54 PEREQFTHCLNAYHARRNVFDLVRTLRVLLDSPVKRRLLPMLRLVIPRSDQLLFDQYTAEGLYLP 118

  Fly  1244 -----------------------------KNQGSLGFSIIGGTDHSCVPFGTREPGIFISHIVPG 1279
                                         |....|||||.||::|..        ||::|.:.||
Mouse   119 ATTPYRQPAWAAPDGAGPGEVRLVSLRRAKAHEGLGFSIRGGSEHGV--------GIYVSLVEPG 175

  Fly  1280 GIASKCGKLRMGDRILKVNEADVSKATHQDAVLELLKPGDEIKLTI------------QH----- 1327
            .:|.|.| ||:||:||:||:..:::.||.:|| :.||...::.|::            .|
Mouse   176 SLAEKEG-LRVGDQILRVNDKSLARVTHAEAV-KALKGSKKLVLSVYSAGRIPGGYVTNHIYTWV 238

  Fly  1328 DP-----LPPGF----------------------------QEVLLSKAEGERLGMHIKGGLNGQR 1359
            ||     .||..                            ::|.|...:|..||:.|:||  .:.
Mouse   239 DPQGRSTSPPSSLPQPHGSTLRQREDDRRSTLHLLQSGDEKKVNLVLGDGRSLGLTIRGG--AEY 301

  Fly  1360 GNPADPSDEGVFVSKINSVGAARRDGRLKVGMRLLEVNGHSLLGASHQDAVNVLRNAGNEIQLVV 1424
            |       .|::::.::....|...| ||||.::|||||.|.|...|.:||.:|:::.:.|..|.
Mouse   302 G-------LGIYITGVDPGSEAESSG-LKVGDQILEVNGRSFLNILHDEAVKLLKSSRHLILTVK 358

  Fly  1425 CKG--------YDKSNLIHS--IGQAGGMSTGFNSSASCSGGSRQGSRASETGSELSQS----QS 1475
            ..|        .|::..|.|  ||::...|.||....:..|.|:.|......||:::.|    |:
Mouse   359 DVGRLPHARTTVDQTKWIASSRIGESVANSAGFPGDHTEEGTSKPGFYKGPAGSQVTLSSLGNQT 423

  Fly  1476 VSSLDHE------EDERLR--------------------------------------------QD 1490
            .:.||.:      |.||..                                            ||
Mouse   424 RALLDDQARHLLTEQERATMMYYLAQYRGGTISVEAMVMALFELLNTHAKFSLLSEVRSIISPQD 488

  Fly  1491 FDVF---------ASQKPDAQQPTGPSVLAAAAAMV-----------HGASS------------- 1522
            .|.|         .|.|  |:||.||.| ....:||           ||.|:
Mouse   489 LDRFDHLVLRREIESMK--ARQPPGPGV-GDTYSMVSYSDTGSSTGSHGTSTTVSSARERLLWLI 550

  Fly  1523 ---------------------------------------------PTPPAATSN----------- 1531
                                                         |.||.|..:
Mouse   551 DLMENTLDLEGTGETTQGSTNALPDVSVDDVKSPSEDLPGIKPPPPPPPLAQGHDRLLGQPRKPG 615

  Fly  1532 -ITPLPTAAAVASADL------------TAP--------DTPATQTVALIHAEQQAHQQQQQTQL 1575
             ..|.|.::|..|..:            |||        |:|::...|.|.....:.::...|.|
Mouse   616 REDPAPLSSAAHSGIVFSAPRNRSPPPGTAPTPGPSSAQDSPSSPIYASISHANPSSRKPLDTHL 680

  Fly  1576 A-----PLG---QEKSTQEKVLEIVRAADAFTTVPPKSPSEHHEQDKI-QKTTTVVISKHTLDTN 1631
            |     |:|   :.:|.............|...:||.|||||  .|.: .....|::..|..|:.
Mouse   681 ALVNQHPIGPFPRVQSPPHLKSPPAETPGAGACLPPPSPSEH--PDAVGANQHFVLVEVHRPDSE 743

  Fly  1632 PTTPTTPAAP----------LSIAGAESANSAGAPSPAVPASTPGSAPVLPAVAVQTQTQTTSTE 1686
            |......|.|          ||.:|...:..:|..:....|||.|..           .||.|.:
Mouse   744 PDVNEVRALPQTRTASTLSQLSDSGQTLSEDSGVDAGETEASTSGRG-----------RQTASAK 797

  Fly  1687 -KDEEEESQLQSTPASRDGAEEQQEEVRAKPTPTKVPKSVS 1726
             |:.:|:.:.:.|   .:||.:....:....|..:|.||.:
Mouse   798 NKNGKEQPRTERT---AEGANKPPGLLEPTSTLVRVRKSAA 835

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064
		leucine-rich repeat	18..38	CDD:275380
		LRR_8	37..95	CDD:290566
		leucine-rich repeat	39..61	CDD:275380
		leucine-rich repeat	62..84	CDD:275380
		LRR_8	84..138	CDD:290566
		leucine-rich repeat	85..107	CDD:275380
		leucine-rich repeat	108..130	CDD:275380
		LRR_8	129..187	CDD:290566
		leucine-rich repeat	131..153	CDD:275380
		leucine-rich repeat	154..176	CDD:275380
		leucine-rich repeat	177..199	CDD:275380
		LRR_8	198..256	CDD:290566
		leucine-rich repeat	200..222	CDD:275380
		leucine-rich repeat	223..245	CDD:275380
		LRR_8	267..325	CDD:290566
		leucine-rich repeat	269..289	CDD:275380
		leucine-rich repeat	292..314	CDD:275380
		leucine-rich repeat	315..337	CDD:275380
		LRR_4	337..375	CDD:289563
		leucine-rich repeat	361..382	CDD:275380
		PDZ	728..816	CDD:214570
		PDZ_signaling	931..1016	CDD:238492
		PDZ	1239..1329	CDD:214570	35/135 (26%)
		PDZ_signaling	1336..1425	CDD:238492	29/88 (33%)
Whrn	NP_001008791.1	HN_L-whirlin_R1_like	38..113	CDD:259822	12/98 (12%)
		PDZ_signaling	139..216	CDD:238492	31/86 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	240..266		3/25 (12%)
		PDZ_signaling	278..358	CDD:238492	28/89 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	387..407		6/19 (32%)
		HN_L-whirlin_R2_like	420..500	CDD:259823	10/79 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	503..538		13/37 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	560..824		52/279 (19%)
		PDZ_signaling	827..898	CDD:238492	3/9 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910