DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment scrib and erbin

DIOPT Version :9

Sequence 1:NP_001163746.1 Gene:scrib / 44448 FlyBaseID:FBgn0263289 Length:2585 Species:Drosophila melanogaster
Sequence 2:XP_004910435.2 Gene:erbin / 734027 XenbaseID:XB-GENE-977040 Length:1446 Species:Xenopus tropicalis


Alignment Length:1608 Identity:434/1608 - (26%)
Similarity:673/1608 - (41%) Gaps:364/1608 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 KCIPIFKGCNRQVEFVDKRHCSLPQVPEEILRYSRTLEELFLDANHIRDLPKNFFRLHRLRKLGL 67
            :|:   :|....|..:|..||||.|||:||..:.:|||||:||||.|.:|||..|....|.||.|
 Frog    15 RCL---RGEEETVTSLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSL 76

  Fly    68 SDNEIGRLPPDIQNFENLVELDVSRNDIPDIPDDIKHLQSLQVADFSSNPIPKLPSGFSQLKNLT 132
            .||::..||..|.|..||.|||||:|.|.:.|::||:.:.|.:.:.|.|||.|||.|||||.|||
 Frog    77 PDNDLTILPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLT 141

  Fly   133 VLGLNDMSLTTLPADFGSLTQLESLELRENLLKHLPETISQLTKLKRLDLGDNEIEDLPPYLGYL 197
            .|.|||..|..|||:||.||:|:.||||||.||.||:|:::||:|:|||||.||..::|..|..|
 Frog   142 QLYLNDAFLDFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQL 206

  Fly   198 PGLHELWLDHNQLQRLPPELGLLTKLTYLDVSENRLEELPNEISGLVSLTDLDLAQNLLEALPDG 262
            .||.|.|:|.|:|..:|..||.|.:|||||||:|.:|.:.:.|||..||.||.|:.|.::.||:.
 Frog   207 SGLKEFWMDGNKLTYIPGFLGNLKQLTYLDVSKNNIEMVEDGISGCESLQDLLLSSNAIQQLPES 271

  Fly   263 IAKLSRLTILKLDQNRLQRLNDTLGNCENMQELILTENFLSELPASIGQMTKLNNLNVDRNALEY 327
            |..|.:||.||:|:|:|..|.|::|....:::|..:.|.:..||:|||.:.::.....|.|.|..
 Frog   272 IGALKKLTTLKVDENQLMYLPDSIGGLTAIEDLDCSFNEIEALPSSIGHLIQIRTFAADHNFLTQ 336

  Fly   328 LPLEIGQCANLGVLSLRDNKLKKLPPELGNCTVLHVLDVSGNQLLYLPYSLVNL-QLKAVWLSEN 391
            ||.|||...:..||.|..|||:.||.|:|:...|.|:::|.|:|..||:|...| ||.|:|||:|
 Frog   337 LPPEIGTWKSATVLFLHSNKLESLPEEMGDMQKLKVINLSDNRLRNLPFSFTRLQQLTAMWLSDN 401

  Fly   392 QSQPLLTFQPDTDAETGEQVLSCYLLPQQEYQPITPARDLESDSEPF-----EEREPSRTVVKFS 451
            ||:||:..|.:||.:|.:.||:.|:.||   ||.|......||:|.|     ||:...|..|.|.
 Frog   402 QSKPLIPLQKETDQDTQKVVLTNYMFPQ---QPRTEDVIFSSDNESFNLSLWEEQRKQRAQVAFE 463

  Fly   452 -EEATQEKETP-----FVRQNTPHPKDLK--AKAQKLKVERSRNEEHANLVTLPEENGTKLAETP 508
             :|...::|.|     ..|..||:|.:||  .|..:..|.|.::||.|      ||...:..:|.
 Frog   464 CDEVRDDREAPAREGILKRYPTPYPDELKNMVKTVQTIVHRKKDEEKA------EEANKETKQTD 522

  Fly   509 TETRTIANNHQQQPHPVQQPIVGVNSKQPVVVGVVTPTTTTVAPTG-VQGGSEGASSTANNVKAA 572
            .:..|:.:             |||.:.:.::|.:.|.......|.. ::...|.::..:|....:
 Frog   523 GDLITLQD-------------VGVKTSEAILVEIDTEDKEKNMPANCIKKLHEPSTENSNGNSQS 574

  Fly   573 TAAV-------VAELAATVGGSDEVQDDDEQEDEFESDRRVGFQVEGEDDDFYKRPPKLHRRDTP 630
            |..|       .|....|:.||:::..|||.:           ..|       .|||        
 Frog   575 TTLVNNFWNAKTANHEDTLEGSEDLSYDDEMK-----------MAE-------MRPP-------- 613

  Fly   631 HHLKNKRVQHLTDKQASEILANALASQERNDTTPQHSLSGKVTSPIEEEEQLEVEQEQQQQQQQH 695
                      |.:...::....||::.:::||....|||.:||.          ...|.......
 Frog   614 ----------LIETSMNQPKVVALSNNKKDDTKDADSLSDEVTR----------NSNQNNSNCSS 658

  Fly   696 P---FDS-SLSPISAGKTAEASTDPD-NLDGVTELRLEQYEIHIERTAAGLGLSIAGGKGSTPFK 755
            |   .|| ||:..|:..|:..|.:.| |:...:::|.|                           
 Frog   659 PSRMSDSVSLNTDSSHDTSLCSPEKDCNIGANSKIRQE--------------------------- 696

  Fly   756 GDDDGI--FISRVTEAGPAD---LAGLKVGDKVIKVNGIVVVDADHYQAVQVLKACGAVLVLVVQ 815
              |:.:  |:....:..|||   ||.|...:     |.:.:|..|.    :|:.:....|.|   
 Frog   697 --DENLNNFMQNGDKLSPADKRELAELPDIN-----NDVELVTRDR----RVINSMEKPLNL--- 747

  Fly   816 REVTRLIGHPVFSEDGSVSQISVETRPLVADAPPAASISHERYIPAPIEIVPQQQHLQQQQQQPI 880
            .::.: ..:.|..|| .:...|||...:..|.....|..:.......||           .....
 Frog   748 NQINK-NNNNVACED-KIHSNSVENSVISKDRVSNKSFGNYNDETDNIE-----------NGNKF 799

  Fly   881 QQVAPTHSYSGNVFATPTAAQTVQPAVSAAPNGLLLNGREAPLSYIQLHTTLIRDQIGQGLGFSI 945
            ..|...:..:|::...|.:..|.:|..|.:         |..:..:.:..:...|.:  .||.|:
 Frog   800 SGVCVMNRVNGHLPEEPVSPDTSEPVRSTS---------EDSVPSVDMCISKSTDDL--SLGDSV 853

  Fly   946 AGGKGSPPFKDDCDGIFISRITEGGLAYRDGKIMVGDRVMAINGNDMTEAHHDAAVACLTEPQRF 1010
            ....||......     |:.|..|.|           |:.::..::....:.....:...|.|..
 Frog   854 GSVVGSVVKSQS-----ITNIETGAL-----------RIYSVLSDNSAPQYATRMSSASAEGQNI 902

  Fly  1011 VR-----LVLQREYRGPLEPPTSPRSPAVLNSLS--------------PSG-YLANRPANFSRSV 1055
            ||     |:..:    ||:..|...|.:.|.:.|              |.| |....|.....|.
 Frog   903 VRSKSATLLCDQ----PLQVFTGSSSSSDLAASSSIKKMLFKFDTNHNPEGPYAVAGPQGSPMSA 963

  Fly  1056 VEVEQPYKYNTLAT----------TTPTPKPTVPAS---------------------ISNNNNTL 1089
            |. :...:|:|.||          :.|..:.|:|:|                     .||:||..
 Frog   964 VP-QYNVQYSTSATAKDNLWSQKQSAPVEQGTLPSSRFHPSDSIDNPNYVKHPSNLNFSNHNNVR 1027

  Fly  1090 PSSKTNGFATAAAATIDSSTGQPVPAPR----RTNSVPMGDGDIGAGSTTS-GDSGEAQPSSLRP 1149
            .|:..|.........:::  ..|.|..|    .|.|.....|.:.:.::.| |::|.|:    |.
 Frog  1028 SSNMYNVHQRMGPRHVEA--WAPTPNDRLLQVATRSTLQRQGSVSSNASVSLGEAGSAR----RV 1086

  Fly  1150 LTSD-DFQAMIPAHFLSGGSQHQVHVARPNEVGVSAVTVNVNKPQPDLPMFPAAPTELGRVTE-T 1212
            |..: |:......|.:|.|:.......||    :||.|.:::  .|::|...:|...:..:.| |
 Frog  1087 LVPEGDYMTYRDLHTVSRGNHMMPGPQRP----MSARTYSID--GPNVPRPQSARPSINDIPERT 1145

  Fly  1213 ITKSTFT----------------------------------ETVMTRITDNQLAEPLISEEV--- 1240
            ::.|.|.                                  |.|:..|...:|.:.::|...   
 Frog  1146 MSVSDFNYSRTSPSKKPNARVNSEHSLLDTQGRSKVPHDWREQVLRHIEAKKLEKSMLSRSFNST 1210

  Fly  1241 -------------VLPKNQGSLGFSIIGGTDHSCVPFGTREPGIFISHIVPGGIASK-------- 1284
                         .|..:|||:..|:        .|......|..:.:..||.:...        
 Frog  1211 FSATSSSLYGSCRDLHGSQGSVALSV--------APDRRASGGHILRYPQPGSVGEPMQDDVFVT 1267

  Fly  1285 --------CGKLRMGDRILKVN------------EADVSKATHQDAVLELLKPGDEIKL------ 1323
                    ..|....|.:.|::            :|:.|:..|..|......|..|..|      
 Frog  1268 GQQSYPTIARKESTADSVKKMHMSNGQMCQPSRPQANYSQLHHHPAQPVGRHPSREQLLDYFTLK 1332

  Fly  1324 -----TIQHDPLPP-----GFQEVLLSKAEGERLGMHIKGGLNGQRGNPADPSDEGVFVSKINSV 1378
                 |....|..|     ..||:.:...:...||..|.||:.| ||||..|.|:|:||:::...
 Frog  1333 VSQQPTYYQIPCSPKQNELSSQEIRVRLVKDPELGFSISGGVGG-RGNPFRPGDDGIFVTRVQPE 1396

  Fly  1379 GAARRDGRLKVGMRLLEVNGHSLLGASHQDAVNVLRNAGNEIQLVVCK 1426
            |.|.:  .|:.|.::|:.||:|.:...|..||.:|:...|.::|:|.:
 Frog  1397 GPASK--LLQPGDKILQANGYSFINIDHAQAVTLLKKFQNAVELMVLR 1442

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
scribNP_001163746.1 LRR_RI 13..283 CDD:238064 140/269 (52%)
leucine-rich repeat 18..38 CDD:275380 10/19 (53%)
LRR_8 37..95 CDD:290566 32/57 (56%)
leucine-rich repeat 39..61 CDD:275380 13/21 (62%)
leucine-rich repeat 62..84 CDD:275380 10/21 (48%)
LRR_8 84..138 CDD:290566 30/53 (57%)
leucine-rich repeat 85..107 CDD:275380 11/21 (52%)
leucine-rich repeat 108..130 CDD:275380 13/21 (62%)
LRR_8 129..187 CDD:290566 36/57 (63%)
leucine-rich repeat 131..153 CDD:275380 13/21 (62%)
leucine-rich repeat 154..176 CDD:275380 13/21 (62%)
leucine-rich repeat 177..199 CDD:275380 11/21 (52%)
LRR_8 198..256 CDD:290566 29/57 (51%)
leucine-rich repeat 200..222 CDD:275380 10/21 (48%)
leucine-rich repeat 223..245 CDD:275380 12/21 (57%)
LRR_8 267..325 CDD:290566 19/57 (33%)
leucine-rich repeat 269..289 CDD:275380 10/19 (53%)
leucine-rich repeat 292..314 CDD:275380 7/21 (33%)
leucine-rich repeat 315..337 CDD:275380 8/21 (38%)
LRR_4 337..375 CDD:289563 15/37 (41%)
leucine-rich repeat 361..382 CDD:275380 9/21 (43%)
PDZ 728..816 CDD:214570 15/92 (16%)
PDZ_signaling 931..1016 CDD:238492 16/89 (18%)
PDZ 1239..1329 CDD:214570 20/144 (14%)
PDZ_signaling 1336..1425 CDD:238492 30/88 (34%)
erbinXP_004910435.2 leucine-rich repeat 24..47 CDD:275380 11/22 (50%)
leucine-rich repeat 48..70 CDD:275380 13/21 (62%)
leucine-rich repeat 71..93 CDD:275380 10/21 (48%)
LRR 89..402 CDD:227223 149/312 (48%)
leucine-rich repeat 94..139 CDD:275380 24/44 (55%)
leucine-rich repeat 117..131 CDD:275378 6/13 (46%)
leucine-rich repeat 140..162 CDD:275380 13/21 (62%)
leucine-rich repeat 163..185 CDD:275380 13/21 (62%)
leucine-rich repeat 186..208 CDD:275380 11/21 (52%)
leucine-rich repeat 209..231 CDD:275380 10/21 (48%)
leucine-rich repeat 232..254 CDD:275380 12/21 (57%)
leucine-rich repeat 255..278 CDD:275380 9/22 (41%)
leucine-rich repeat 279..300 CDD:275380 9/20 (45%)
leucine-rich repeat 301..336 CDD:275380 10/34 (29%)
leucine-rich repeat 337..369 CDD:275380 15/31 (48%)
leucine-rich repeat 370..390 CDD:275380 8/19 (42%)
PDZ_signaling 1355..1441 CDD:238492 30/88 (34%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D148064at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.010

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