DRSC/TRiP Functional Genomics Resources

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Protein Alignment scrib and rapgef6

DIOPT Version :9

Sequence 1:NP_001163746.1 Gene:scrib / 44448 FlyBaseID:FBgn0263289 Length:2585 Species:Drosophila melanogaster
Sequence 2:NP_001361718.1 Gene:rapgef6 / 733941 XenbaseID:XB-GENE-981546 Length:1644 Species:Xenopus tropicalis


Alignment Length:1980 Identity:342/1980 - (17%)
Similarity:610/1980 - (30%) Gaps:605/1980 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   338 LGVLS-LRDNKLKKLPPELGNCTVLHVLDVSGNQLLYLPYSLVN----LQLKAVWLSENQSQPLL 397
            :.:|| ||:::|:     |.:.|..:. ..|.||:|:...||..    |...:|.:..:...|..
 Frog    35 MDILSHLREHQLR-----LMSATARYE-RYSANQVLFCSESLARCWYILLSGSVLVKNSMFLPPC 93

  Fly   398 TFQPDTDAETGEQVLSCYLLPQQEYQPITPARDLESDSEPFEEREPSRTVVKFSEEATQE----- 457
            :|...:..:.|   ..|.:|                        |||..:|   .|.|.|     
 Frog    94 SFGKQSGGKRG---CDCIVL------------------------EPSEMIV---VENTGENNDGI 128

  Fly   458 --KETPFVRQNTPHPKDLKAKAQKLKVERSRNEEHANLVTLPEENGTKLAETPTETRTIANNH-Q 519
              :||. :||:....:.:....::..:  :.|.:.|:.|.||.:              ::..| .
 Frog   129 LHRETS-IRQSRRRYRKINQHGERQTI--TDNGDAASYVLLPTD--------------LSKIHLT 176

  Fly   520 QQPHPVQQPIVGVNSKQPVVVGVVTPTTTTVAPTGVQGGSEGASSTANNVKAATAAVVAELAATV 584
            ..|||   .:..|.|.|                :|....|:..||:.:::..||.:.:.::..| 
 Frog   177 DSPHP---HVTHVPSSQ----------------SGCSIASDSGSSSLSDIYQATESEMGDVDLT- 221

  Fly   585 GGSDEVQDDDEQEDEFESDRRVGFQVEGEDDDFYKRPPKLHRRDTPHHLKNKRVQHLTDKQASEI 649
             |..|...|.|.|:              ||:|..:....:..||.......|.....||....::
 Frog   222 -GLPEAAVDSEDEE--------------EDEDIERASDTMLTRDIVRECLEKEPTDRTDDDIEQL 271

  Fly   650 L---------ANALASQERNDTTPQHSLSGKVTSPIEEEEQLEVEQEQQQQ----------QQQH 695
            |         .|...|..|.      ..|..:...:|:...:.:|..|:..          :..|
 Frog   272 LEFMHQLPAFVNMTMSVRRK------LCSVMIFEVVEQAGAIIIEDGQELDSWYVILNGIVEISH 330

  Fly   696 PFDSSLSPISAGKT--AEASTDPDNLDGVTELRLEQYEI-------------HIERTAAGLGLSI 745
            . |..:..:..|.:  ...|.:...:|||.:.:.:..:.             |:|:..       
 Frog   331 S-DGRMENLCMGNSFGINPSLETQYMDGVVKTKADDCQFVCIAQQDYFRILNHVEKNT------- 387

  Fly   746 AGGKGSTPFKGDDDGIFISRVTEAGPADLAGLKVGDKVIKVNGIVVVDADHYQAVQVLKACGAVL 810
                .....||:     |..|.|....|.:|.:.|.                             
 Frog   388 ----HKVKEKGE-----IVMVNEHRELDRSGTRKGH----------------------------- 414

  Fly   811 VLVVQREVTRLIGHPVFSEDGSVSQISVETRPLVADAPPAASISHERYIPAPIEIVPQ--QQHLQ 873
             :|:|....|||.| :..|...|....:|.          ..:::..::.:|:|:..:  :....
 Frog   415 -IVIQGTPERLILH-LIEEHSVVDPTYIED----------FLLTYRTFLSSPLEVGDKLLEWFKD 467

  Fly   874 QQQQQPIQQVA------PTHSYSGNVFATPTAAQTVQPAVSAAPNG--LLLN---GREAPLSYIQ 927
            ..::..:.:|.      ..:.:.|:...|....:..:...:|...|  .|||   ..:|.|..: 
 Frog   468 DSRRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFERNLENAKMKGHLRLLNIACAAKAKLRQV- 531

  Fly   928 LHTTLIRDQIGQGLGFSIAGGKGSPPFKDDCDGIFISRITEGGLAYRDGKIMVGDRVMAINGNDM 992
               ||::........|::.||      .|...|:||..:..|..|...| :..||::|.:||   
 Frog   532 ---TLLKPSRESPFYFNVVGG------SDKGFGMFIESVEPGSKATEAG-LKRGDQIMEVNG--- 583

  Fly   993 TEAHHDAAVACLTEPQRFVRLVLQREYRGPLE--PPTSPRSPAVLNSLSPSGYLANRPANFSRSV 1055
                           |.|..:|    |...||  ...:..|..|..::.....|.||.....::.
 Frog   584 ---------------QNFETIV----YAKALEILKNNTHLSITVKTNIFVFKELLNRIGQEKKNG 629

  Fly  1056 VEVEQPYKYNTLATTTPTPKPTVP--ASISNNNNTLPSSKTNGFATAAAATIDSSTGQPVPAPRR 1118
            |                   |.:|  |...||..::|.             :.:...|..|..|.
 Frog   630 V-------------------PHIPKIAEKKNNRYSIPD-------------LPNDVEQMFPRDRA 662

  Fly  1119 TNSVPMGDGDIGAGSTTSGDSGEAQPSSLRPLTSDDFQAMIPAHFLSGGSQHQVHVARPNE---- 1179
            :..:        ..:|.||.....:    :.|....|..:.|..|..|      ||.:..:    
 Frog   663 SKKM--------KANTVSGGRNRIR----KILDKTRFSILPPKPFSDG------HVIQSQDDSIV 709

  Fly  1180 --------VGVSAVTVNVNKPQPDLPMFPAAPTELGRVTETITKSTFTETVMTRI--TDNQ---- 1230
                    |.:..:...::...|||  ..|....|.....|.....:....:.||  .|.|    
 Frog   710 GTRQCRHSVAIMPIPGTLSSSSPDL--LQATTNILDFSNPTAFGFYYIPDQVIRIFKADQQCCYI 772

  Fly  1231 -LAEPLISEEVVLPKNQGSLGFSIIGGTD-HSCVPFGTREPGIFISHIVPGGIASKCGKLRMGDR 1293
             :.:...::|||:   |....||:.|.|| :|.........|:.....:|..::....::::..|
 Frog   773 IIGKDTTAKEVVI---QALHEFSLTGSTDTYSLCEVSVSPEGVIKQRRLPDQLSKLADRIQLNGR 834

  Fly  1294 ILKVNEADVSKATHQDAVLELLKPGDEIKLTIQHDPLPPGFQEVLLSKAEGERLGMHIKGGLNGQ 1358
            ....|..:.......:...|||:  :.:...:|...:....|   ||..:.| |..:|:      
 Frog   835 YYLKNNMETETLCSDEDAQELLR--ESLISLLQLSTIEVATQ---LSMRDFE-LFRNIE------ 887

  Fly  1359 RGNPADPSDEGVFVSKINSVGAARRDGRLKVGMRLLEVNGHSLLGASHQDAVNVLRNAGNEIQLV 1423
               |.:..|:   :.||:|..:|   ..||   :..||........    |..:||...:..::.
 Frog   888 ---PTEYIDD---LFKIDSKTSA---AHLK---QFEEVINQETFWV----ATEILREPNHLKRMK 936

  Fly  1424 VCKGYDKSNLIHSIGQAGGMSTGFNSSASCSGGSRQGSRASETGSELSQSQSVSSLDHEEDERLR 1488
            :.|.:.|:.|                            ...|..:..|....:|.|:.....|||
 Frog   937 IVKHFIKTAL----------------------------HCRECRNFNSMFAIISGLNLAPVARLR 973

  Fly  1489 QDFDVFASQKP----DAQQPTGPSVLAAAAAMVHGASSPTPPAATSNITPLPTAAAVASADLTAP 1549
            ..::...|:..    |.|....||...|....:..:.|..||     |.||   ..|...|:|  
 Frog   974 GTWEKLPSKYEKLLRDLQDLFDPSRNMAKYRNILSSQSMQPP-----IIPL---FPVVKKDIT-- 1028

  Fly  1550 DTPATQTVALIHAEQQAHQQQQQTQLAPLGQEKSTQEKVLEIVRAADAFTTVPPKSPSEHHEQDK 1614
                     .:|....:    :...|....:.:...:::..::|...|     ...|:....|.|
 Frog  1029 ---------FLHEGNDS----KVDGLVNFEKLRMIAKEIRHVIRMTSA-----NMDPAVMFRQRK 1075

  Fly  1615 IQKTTTVVISKHTLDTNPTTPTTPAAPLSIAGAESANSAGAPSPAVPASTPGSAPVLPAVA---- 1675
            .:..:...:|:.:.::|         .|.:.|       |........|:..:|..|...|    
 Frog  1076 KRWRSLGSLSQGSTNSN---------MLDVQG-------GGHKKRARRSSFLNAKKLYEDAQMSR 1124

  Fly  1676 -VQTQTQTTSTEKDEE--EESQLQSTPASRDGAEEQQEEVRAK----PTPTKVPKSVSDKKRFFE 1733
             |:......|.|.|||  :...||..||....|:...|...||    |.|.: |...:.|....:
 Frog  1125 KVKQYISNLSVEIDEEKIQLMSLQCEPAYSTLAKNLSERRSAKSDLSPAPLR-PSGQTTKAHIHQ 1188

  Fly  1734 --------------------SAMEDQHKP-TQKTDKVFSFLSKDEVEKLRQEEE----------- 1766
                                .|...:|.| |..:.:..|.|: |||....|.|:           
 Frog  1189 QNRMSQVLQVPTVNLYPMRKKAPTKEHLPCTSGSSQKISGLT-DEVTVKAQLEDSVSLVSSLHSS 1252

  Fly  1767 ---------RKIATLRRDKNS--RLLDAANDNIDKDAAQQRTK--------SNSNSSSGDDNDDS 1812
                     .|:..:.|.:||  ..|..::.::..|..|:...        :::.|:..|:..||
 Frog  1253 PAASPQGSPHKVVNISRSENSSHMNLSGSSSSLTSDPNQKICSRRGYGIGYAHNPSAKSDNFSDS 1317

  Fly  1813 DQEEGIARGDSVDNAALGHFDDAEDMRTAQSLASTMPHAPSK---IPKQKLKAKQIESSLPTPTA 1874
            ...|..:|...|.|.::      :.|.........:||:.::   :.::|......|.:.|..:.
 Frog  1318 SNSEISSRSSLVSNCSV------DSMSLTLQDEKCVPHSHAESMGLSERKDVHPSSEYNQPCSSW 1376

  Fly  1875 LDPPKPSLLPKPKVKVVIPPALQQRLKQQQVQQQ-------------QQQHQQSQPEEPSIPEEE 1926
            |....|:      |:..|..|..:.:....:..:             ...|...|..:..:....
 Frog  1377 LHARHPA------VRNFIACASSEDIAHDHISVEPVDSGRGSWTSCSSSSHDNFQTLQKGLDRLS 1435

  Fly  1927 YHQQPEPDSPSA-----------------AGGSR------------------------------- 1943
            .::|...|||.|                 ..|.|                               
 Frog  1436 TYRQSHIDSPIAETESANCSTDETCSEDCTKGKRHSNNSLELNESRQSWASSSSMSDTYETNYGT 1500

  Fly  1944 IPVRTLKAERRALTLAARQSGLSVEEYLKRL--------------ETQDDKESPASPTTPTGKSR 1994
            |..|.|..|.:...|     |..::.:.|.:              .:|.|......|.||.|...
 Frog  1501 IKRRVLDTEEKTEAL-----GQQLDVFYKTVTSTTEKGLIVYCVTSSQKDSRYREPPPTPPGYQG 1560

  Fly  1995 SMINAEKRASWRAARLRSLEQGAVEAQDVIKNMRKMTDDLITHESRASEVETC-KERIISLELQV 2058
            ..:...|......|.|:..:...     .|:..:.:..||....|...|..:| .:::|      
 Frog  1561 ISLADIKEGQPHQAHLKPPDYSV-----AIQRSKMIHKDLSRLSSACVEPVSCVSQKMI------ 1614

  Fly  2059 PETEDEGKLDDTQPPLELEAD-DFQDDEDD 2087
              |....:   .||...::|| |.::|||:
 Frog  1615 --THWHNR---HQPYPNVQADRDSKEDEDE 1639

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
scribNP_001163746.1 LRR_RI 13..283 CDD:238064
leucine-rich repeat 18..38 CDD:275380
LRR_8 37..95 CDD:290566
leucine-rich repeat 39..61 CDD:275380
leucine-rich repeat 62..84 CDD:275380
LRR_8 84..138 CDD:290566
leucine-rich repeat 85..107 CDD:275380
leucine-rich repeat 108..130 CDD:275380
LRR_8 129..187 CDD:290566
leucine-rich repeat 131..153 CDD:275380
leucine-rich repeat 154..176 CDD:275380
leucine-rich repeat 177..199 CDD:275380
LRR_8 198..256 CDD:290566
leucine-rich repeat 200..222 CDD:275380
leucine-rich repeat 223..245 CDD:275380
LRR_8 267..325 CDD:290566
leucine-rich repeat 269..289 CDD:275380
leucine-rich repeat 292..314 CDD:275380
leucine-rich repeat 315..337 CDD:275380
LRR_4 337..375 CDD:289563 11/37 (30%)
leucine-rich repeat 361..382 CDD:275380 6/24 (25%)
PDZ 728..816 CDD:214570 11/100 (11%)
PDZ_signaling 931..1016 CDD:238492 20/84 (24%)
PDZ 1239..1329 CDD:214570 18/90 (20%)
PDZ_signaling 1336..1425 CDD:238492 18/88 (20%)
rapgef6NP_001361718.1 CAP_ED 37..119 CDD:381773 24/117 (21%)
CAP_ED 280..380 CDD:237999 14/106 (13%)
RasGEFN 412..525 CDD:214571 20/153 (13%)
PDZ_signaling 528..609 CDD:238492 25/113 (22%)
RA_PDZ-GEF1 758..840 CDD:340483 17/84 (20%)
RasGEF 863..1097 CDD:214539 55/324 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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