Protein Alignment scrib and Lrch2

DIOPT Version :10

• Sequence 1: NP_001163746.1
• Gene: scrib / 44448
• FlyBaseID: FBgn0263289
• Length: 2585
• Species: Drosophila melanogaster
• Sequence 2: XP_038956102.2
• Gene: Lrch2 / 680591
• RGDID: 1590569
• Length: 823
• Species: Rattus norvegicus
• Alignment Length: 689
• Identity: 142/689 - (20%)
• Similarity: 234/689 - (33%)
• Gaps: 228/689 - (33%)

  Fly   110 VADFSSNPIPKLPSGFSQLKNLTVLGLNDMSLTTLPADFGSLTQLESLELRENLLKHLPETISQL 174
            :...|...:.:.|.....|.:.|...|:....|.:|:|......||:|.|..|.:|.:||.|..|
  Rat   125 ILSLSGRKLREFPGSGYDLTDTTQADLSRNRFTEIPSDVWLFAPLETLNLYHNCIKTIPEAIKNL 189

  Fly   175 TKLKRLDLGDNEIEDLPPYLGYLPGLHELWLDHNQLQRLPPELGLLTKLTYLDVSENRLEELPNE 239
            ..|..|::..|.:..||.||..|| |..|.:.:|:|..:|.|:|.|..|..||:|.|.::.||.:
  Rat   190 QMLTYLNISRNLLSTLPKYLFDLP-LKVLVVSNNKLVSIPEEIGKLKDLMELDISCNEIQVLPQQ 253

  Fly   240 ISGLVSLTDLDLAQNLLEALPDGIAKLSRLTILKLDQNRLQRLNDTLGNCENMQELILTENFLSE 304
            :..|.||.:|::.:|.|..|||   :|..|.::|||           .:|          |.::|
  Rat   254 MGKLHSLKELNIRRNNLHVLPD---ELGDLPLVKLD-----------FSC----------NKVTE 294

  Fly   305 LPASIGQMTKLNNLNVDRNALEYLPLEIGQCANLGVLSLRDNKLKKLPPELGNCTVLHVLDVSGN 369
            :|....::.:|..:.:|.|.|:..|.:|  |            ||      |...:...|::
  Rat   295 IPVCYRKLHQLQVIILDNNPLQVPPAQI--C------------LK------GKVHIFKYLNI--- 336

  Fly   370 QLLYLPYSLVNLQLKAVWLSENQSQPLLTFQPDTDAETGEQVLSCYLLPQQEYQPITPARDLESD 434
                                  |:...:..:||          |..|....:..|..|..|...|
  Rat   337 ----------------------QACCRMDKKPD----------SLDLPSLNKRMPSQPLTDSMED 369

  Fly   435 SEPFEEREPSRTVVKFSEEATQEKETPFVRQNTPHPKD---LKAKAQKLKVERSRNEEHANLVTL 496
            ..|.:...|...:...:.|.         |.:|..|.|   :...:|..:..|.:.....:|||
  Rat   370 FYPNKNHGPDSGIGSDNGEK---------RLSTTEPSDDDTISLHSQVSESNREQTSRTDSLVT- 424

  Fly   497 PEENGTKLAETPTETRTIANNHQQQPHPVQQPIVGVNSKQPVVVGVVTPTTTTVAPTGVQGGSEG 561
                |||                    |..|       |...|...:.|.|..|| ...||.:.
  Rat   425 ----GTK--------------------PDSQ-------KDQEVYDFIDPNTEEVA-VPEQGDTH- 456

  Fly   562 ASSTANNVKAATAAVVAELAATVGGSDEVQDDDEQEDEFESDRRVGFQ--VEGEDDDFYK----- 619
                           :....:.:.|.::..:..::.:|..::::|..:  :..||||..:
  Rat   457 ---------------IGSFVSFLKGKEKCPEKSQKNEELGNEKKVDKEQLLPEEDDDLKEVTDLR 506

  Fly   620 ---------------RP--------PKLHRRDTPHHLKNKRVQHLTD------KQASEILANALA 655
                           ||        .||.:|......|::.:.|.|.      ||..| ...:::
  Rat   507 KIAAQLLKQEQKNRWRPLSYRTSFSDKLFQRTRAAGRKSRILNHSTSVMRNKLKQTVE-CEKSVS 570

  Fly   656 SQERNDTTPQHSLSGKVTSPIEEEEQLEVEQ---------------------------------- 686
            :.|.|.     .||.....|:|.::...|:|
  Rat   571 ADEGNS-----PLSPLAWQPLENQKDQIVDQQWPESQPIIWQNEERRRSKQIRKEYFKYKSTRKN 630

  Fly   687 ----EQQQQQQQHPFDSSLSPISAGKTAEASTDPDNLDG 721
                |.::|:..:...|..||:|       |.|.|..||
  Rat   631 SSGNENEEQESDNAHMSPQSPVS-------SEDYDRSDG 662

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	leucine-rich repeat	18..38	CDD:275380
		LRR_8	37..95	CDD:404697
		leucine-rich repeat	39..61	CDD:275380
		leucine-rich repeat	62..84	CDD:275380
		LRR	67..408	CDD:443914	74/297 (25%)
		leucine-rich repeat	85..107	CDD:275380
		leucine-rich repeat	108..130	CDD:275380	3/19 (16%)
		leucine-rich repeat	131..153	CDD:275380	5/21 (24%)
		leucine-rich repeat	154..176	CDD:275380	10/21 (48%)
		leucine-rich repeat	177..199	CDD:275380	8/21 (38%)
		leucine-rich repeat	200..222	CDD:275380	8/21 (38%)
		leucine-rich repeat	223..245	CDD:275380	8/21 (38%)
		leucine-rich repeat	269..289	CDD:275380	4/19 (21%)
		leucine-rich repeat	292..314	CDD:275380	3/21 (14%)
		leucine-rich repeat	315..337	CDD:275380	7/21 (33%)
		leucine-rich repeat	361..382	CDD:275380	1/20 (5%)
		PDZ1_Scribble-like	730..816	CDD:467188
		PDZ2_Scribble-like	927..1019	CDD:467187
		PDZ3_Scribble-like	1238..1327	CDD:467186
		PDZ4_Scribble-like	1331..1428	CDD:467185
Lrch2	XP_038956102.2	None