DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scrib and Lrch2

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	XP_038956102.1	Gene:	Lrch2 / 680591	RGDID:	1590569	Length:	798	Species:	Rattus norvegicus

Alignment Length:	689	Identity:	142/689 - (20%)
Similarity:	234/689 - (33%)	Gaps:	228/689 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 VADFSSNPIPKLPSGFSQLKNLTVLGLNDMSLTTLPADFGSLTQLESLELRENLLKHLPETISQL 174
            :...|...:.:.|.....|.:.|...|:....|.:|:|......||:|.|..|.:|.:||.|..|
  Rat   100 ILSLSGRKLREFPGSGYDLTDTTQADLSRNRFTEIPSDVWLFAPLETLNLYHNCIKTIPEAIKNL 164

  Fly   175 TKLKRLDLGDNEIEDLPPYLGYLPGLHELWLDHNQLQRLPPELGLLTKLTYLDVSENRLEELPNE 239
            ..|..|::..|.:..||.||..|| |..|.:.:|:|..:|.|:|.|..|..||:|.|.::.||.:
  Rat   165 QMLTYLNISRNLLSTLPKYLFDLP-LKVLVVSNNKLVSIPEEIGKLKDLMELDISCNEIQVLPQQ 228

  Fly   240 ISGLVSLTDLDLAQNLLEALPDGIAKLSRLTILKLDQNRLQRLNDTLGNCENMQELILTENFLSE 304
            :..|.||.:|::.:|.|..|||   :|..|.::|||           .:|          |.::|
  Rat   229 MGKLHSLKELNIRRNNLHVLPD---ELGDLPLVKLD-----------FSC----------NKVTE 269

  Fly   305 LPASIGQMTKLNNLNVDRNALEYLPLEIGQCANLGVLSLRDNKLKKLPPELGNCTVLHVLDVSGN 369
            :|....::.:|..:.:|.|.|:..|.:|  |            ||      |...:...|::
  Rat   270 IPVCYRKLHQLQVIILDNNPLQVPPAQI--C------------LK------GKVHIFKYLNI--- 311

  Fly   370 QLLYLPYSLVNLQLKAVWLSENQSQPLLTFQPDTDAETGEQVLSCYLLPQQEYQPITPARDLESD 434
                                  |:...:..:||          |..|....:..|..|..|...|
  Rat   312 ----------------------QACCRMDKKPD----------SLDLPSLNKRMPSQPLTDSMED 344

  Fly   435 SEPFEEREPSRTVVKFSEEATQEKETPFVRQNTPHPKD---LKAKAQKLKVERSRNEEHANLVTL 496
            ..|.:...|...:...:.|.         |.:|..|.|   :...:|..:..|.:.....:|||
  Rat   345 FYPNKNHGPDSGIGSDNGEK---------RLSTTEPSDDDTISLHSQVSESNREQTSRTDSLVT- 399

  Fly   497 PEENGTKLAETPTETRTIANNHQQQPHPVQQPIVGVNSKQPVVVGVVTPTTTTVAPTGVQGGSEG 561
                |||                    |..|       |...|...:.|.|..|| ...||.:.
  Rat   400 ----GTK--------------------PDSQ-------KDQEVYDFIDPNTEEVA-VPEQGDTH- 431

  Fly   562 ASSTANNVKAATAAVVAELAATVGGSDEVQDDDEQEDEFESDRRVGFQ--VEGEDDDFYK----- 619
                           :....:.:.|.::..:..::.:|..::::|..:  :..||||..:
  Rat   432 ---------------IGSFVSFLKGKEKCPEKSQKNEELGNEKKVDKEQLLPEEDDDLKEVTDLR 481

  Fly   620 ---------------RP--------PKLHRRDTPHHLKNKRVQHLTD------KQASEILANALA 655
                           ||        .||.:|......|::.:.|.|.      ||..| ...:::
  Rat   482 KIAAQLLKQEQKNRWRPLSYRTSFSDKLFQRTRAAGRKSRILNHSTSVMRNKLKQTVE-CEKSVS 545

  Fly   656 SQERNDTTPQHSLSGKVTSPIEEEEQLEVEQ---------------------------------- 686
            :.|.|.     .||.....|:|.::...|:|
  Rat   546 ADEGNS-----PLSPLAWQPLENQKDQIVDQQWPESQPIIWQNEERRRSKQIRKEYFKYKSTRKN 605

  Fly   687 ----EQQQQQQQHPFDSSLSPISAGKTAEASTDPDNLDG 721
                |.::|:..:...|..||:|       |.|.|..||
  Rat   606 SSGNENEEQESDNAHMSPQSPVS-------SEDYDRSDG 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064	56/172 (33%)
		leucine-rich repeat	18..38	CDD:275380
		LRR_8	37..95	CDD:290566
		leucine-rich repeat	39..61	CDD:275380
		leucine-rich repeat	62..84	CDD:275380
		LRR_8	84..138	CDD:290566	5/27 (19%)
		leucine-rich repeat	85..107	CDD:275380
		leucine-rich repeat	108..130	CDD:275380	3/19 (16%)
		LRR_8	129..187	CDD:290566	18/57 (32%)
		leucine-rich repeat	131..153	CDD:275380	5/21 (24%)
		leucine-rich repeat	154..176	CDD:275380	10/21 (48%)
		leucine-rich repeat	177..199	CDD:275380	8/21 (38%)
		LRR_8	198..256	CDD:290566	21/57 (37%)
		leucine-rich repeat	200..222	CDD:275380	8/21 (38%)
		leucine-rich repeat	223..245	CDD:275380	8/21 (38%)
		LRR_8	267..325	CDD:290566	11/57 (19%)
		leucine-rich repeat	269..289	CDD:275380	4/19 (21%)
		leucine-rich repeat	292..314	CDD:275380	3/21 (14%)
		leucine-rich repeat	315..337	CDD:275380	7/21 (33%)
		LRR_4	337..375	CDD:289563	4/37 (11%)
		leucine-rich repeat	361..382	CDD:275380	1/20 (5%)
		PDZ	728..816	CDD:214570
		PDZ_signaling	931..1016	CDD:238492
		PDZ	1239..1329	CDD:214570
		PDZ_signaling	1336..1425	CDD:238492
Lrch2	XP_038956102.1	PRK15370	<82..>290	CDD:185268	63/214 (29%)
		leucine-rich repeat	100..120	CDD:275380	3/19 (16%)
		leucine-rich repeat	121..143	CDD:275380	5/21 (24%)
		leucine-rich repeat	144..166	CDD:275380	10/21 (48%)
		leucine-rich repeat	167..182	CDD:275380	4/14 (29%)
		leucine-rich repeat	189..211	CDD:275380	8/21 (38%)
		leucine-rich repeat	212..234	CDD:275380	8/21 (38%)
		leucine-rich repeat	235..255	CDD:275380	8/22 (36%)
		leucine-rich repeat	257..279	CDD:275380	7/42 (17%)
		leucine-rich repeat	280..298	CDD:275380	6/19 (32%)
		CH_LRCH2	676..786	CDD:409120
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910