DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scrib and SLIT3

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	NP_001258875.2	Gene:	SLIT3 / 6586	HGNCID:	11087	Length:	1530	Species:	Homo sapiens

Alignment Length:	606	Identity:	145/606 - (23%)
Similarity:	217/606 - (35%)	Gaps:	209/606 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 CNRQVEFVDKRHCSLPQVPEEILRYSRTLEELFLDANHIRDLPK-NFFRLHRLRKLGLSDNEIG- 73
            |......||.....|..||..|   .|..|.|.||.|:|..:.| :|..|..||.|.|.||::.
Human    38 CTCSAASVDCHGLGLRAVPRGI---PRNAERLDLDRNNITRITKMDFAGLKNLRVLHLEDNQVSV 99

  Fly    74 ----------------------RLPPDI--QNFENLVELDVSRNDIPDIP-------DDIKHLQS 107
                                  ::.|::  |:...|..||:|.|.|..||       .|:|:||
Human   100 IERGAFQDLKQLERLRLNKNKLQVLPELLFQSTPKLTRLDLSENQIQGIPRKAFRGITDVKNLQ- 163

  Fly   108 LQVADFSSNPIPKLPSG-FSQLKNLTVLGLNDMSLT-TLPADFGSLTQLESLELRENLLK---HL 167
                 ..:|.|..:..| |..|::|.:|.||:.::: .|...|..:.::.:|.|..|.|.   ||
Human   164 -----LDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHLYCDCHL 223

  Fly   168 P---------ETISQLT------KLKRLDLGD--------------------------------N 185
            .         .|:.|.|      .|:..::.|                                |
Human   224 AWLSDWLRQRRTVGQFTLCMAPVHLRGFNVADVQKKEYVCPAPHSEPPSCNANSISCPSPCTCSN 288

  Fly   186 EIED-----LPPYLGYLP-GLHELWLDHNQLQRLPPELGLLT---KLTYLDVSENRLEEL-PNEI 240
            .|.|     |......|| |:.|:.|:.|.::.:|  .|..|   ||..:|:|:|::.:: |:..
Human   289 NIVDCRGKGLMEIPANLPEGIVEIRLEQNSIKAIP--AGAFTQYKKLKRIDISKNQISDIAPDAF 351

  Fly   241 SGLVSLTDLDLAQN----LLEALPDGIAKLSRLTILKLDQNRLQRLNDTLGNCENMQELILTENF 301
            .||.|||.|.|..|    :::.|.||:..|                          |.|:|..|
Human   352 QGLKSLTSLVLYGNKITEIVKGLFDGLVSL--------------------------QLLLLNAN- 389

  Fly   302 LSELPASIGQMTKLNNLNVDRNALEYLPLEIGQCANLGVLSLRDNKL----KKLPPELGNCTVLH 362
                        |:|.|.|  |..:.|       .||.:|||.||||    |.|...|.:...||
Human   390 ------------KINCLRV--NTFQDL-------QNLNLLSLYDNKLQTISKGLFAPLQSIQTLH 433

  Fly   363 VLDVSGNQLLYLPYSLVNLQLKAVWLSEN-QSQPLLTFQPDTDAETGEQVLSCYLLPQQEYQPIT 426
                    |...|: :.:..||  ||::. |..|:.|        :|.:..|...|..:....|.
Human   434 --------LAQNPF-VCDCHLK--WLADYLQDNPIET--------SGARCSSPRRLANKRISQIK 479

  Fly   427 PARDLESDSEPFEEREPSRTVVKFSEEATQEKETPFVRQNTPHPKDLKAKAQKLKVERSRNEEHA 491
            ..:...|.||.:..|        ||.|...:...|           .|.:.:...|:.|..:
Human   480 SKKFRCSGSEDYRSR--------FSSECFMDLVCP-----------EKCRCEGTIVDCSNQK--- 522

  Fly   492 NLVTLPEENGTKLAETPTETR 512
             ||.:|    :.|.|..|:.|
Human   523 -LVRIP----SHLPEYVTDLR 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064	89/368 (24%)
		leucine-rich repeat	18..38	CDD:275380	6/19 (32%)
		LRR_8	37..95	CDD:290566	23/83 (28%)
		leucine-rich repeat	39..61	CDD:275380	9/22 (41%)
		leucine-rich repeat	62..84	CDD:275380	8/46 (17%)
		LRR_8	84..138	CDD:290566	20/61 (33%)
		leucine-rich repeat	85..107	CDD:275380	11/28 (39%)
		leucine-rich repeat	108..130	CDD:275380	5/22 (23%)
		LRR_8	129..187	CDD:290566	18/108 (17%)
		leucine-rich repeat	131..153	CDD:275380	6/22 (27%)
		leucine-rich repeat	154..176	CDD:275380	9/39 (23%)
		leucine-rich repeat	177..199	CDD:275380	8/59 (14%)
		LRR_8	198..256	CDD:290566	22/66 (33%)
		leucine-rich repeat	200..222	CDD:275380	6/24 (25%)
		leucine-rich repeat	223..245	CDD:275380	7/22 (32%)
		LRR_8	267..325	CDD:290566	9/57 (16%)
		leucine-rich repeat	269..289	CDD:275380	0/19 (0%)
		leucine-rich repeat	292..314	CDD:275380	4/21 (19%)
		leucine-rich repeat	315..337	CDD:275380	5/21 (24%)
		LRR_4	337..375	CDD:289563	15/41 (37%)
		leucine-rich repeat	361..382	CDD:275380	4/20 (20%)
		PDZ	728..816	CDD:214570
		PDZ_signaling	931..1016	CDD:238492
		PDZ	1239..1329	CDD:214570
		PDZ_signaling	1336..1425	CDD:238492
SLIT3	NP_001258875.2	LRRNT	33..64	CDD:214470	8/28 (29%)
		LRR	<62..>220	CDD:227223	44/163 (27%)
		LRR 1	62..83		8/20 (40%)
		leucine-rich repeat	64..86	CDD:275380	9/21 (43%)
		LRR 2	86..107		6/20 (30%)
		leucine-rich repeat	87..110	CDD:275380	6/22 (27%)
		internalin_A	107..>478	CDD:380193	103/445 (23%)
		LRR 3	110..131		1/20 (5%)
		leucine-rich repeat	111..134	CDD:275380	2/22 (9%)
		LRR 4	134..155		8/20 (40%)
		leucine-rich repeat	135..158	CDD:275380	8/22 (36%)
		LRR 5	158..179		8/26 (31%)
		leucine-rich repeat	159..182	CDD:275380	8/28 (29%)
		LRR 6	182..203		6/20 (30%)
		leucine-rich repeat	183..206	CDD:275380	6/22 (27%)
		leucine-rich repeat	207..308	CDD:275380	17/100 (17%)
		LRR 7	308..329		6/22 (27%)
		leucine-rich repeat	309..332	CDD:275380	6/24 (25%)
		LRR_8	311..367	CDD:338972	20/57 (35%)
		LRR 8	332..353		6/20 (30%)
		leucine-rich repeat	333..356	CDD:275380	7/22 (32%)
		LRR 9	356..377		7/20 (35%)
		leucine-rich repeat	357..377	CDD:275380	6/19 (32%)
		LRR 10	380..401		10/61 (16%)
		leucine-rich repeat	381..404	CDD:275380	11/70 (16%)
		LRR 11	404..425		11/20 (55%)
		leucine-rich repeat	405..428	CDD:275380	11/22 (50%)
		LRRNT	505..535	CDD:214470	9/48 (19%)
		LRR 12	533..554		2/6 (33%)
		LRR_8	534..593	CDD:338972	2/5 (40%)
		leucine-rich repeat	534..558	CDD:275380	2/5 (40%)
		LRR 13	558..579
		leucine-rich repeat	559..582	CDD:275380
		LRR_8	582..641	CDD:338972
		LRR 14	582..603
		leucine-rich repeat	583..606	CDD:275380
		LRR 15	606..627
		leucine-rich repeat	607..630	CDD:275380
		LRR 16	630..651
		leucine-rich repeat	631..654	CDD:275380
		PCC	636..>714	CDD:188093
		leucine-rich repeat	655..745	CDD:275380
		LRRNT	725..756	CDD:214470
		LRR	<743..>869	CDD:227223
		leucine-rich repeat	746..776	CDD:275380
		LRR 17	753..775
		LRR_8	776..835	CDD:338972
		LRR 18	776..797
		leucine-rich repeat	777..800	CDD:275380
		LRR 19	800..821
		leucine-rich repeat	801..824	CDD:275380
		LRR 20	824..845
		leucine-rich repeat	825..846	CDD:275380
		PCC	830..>912	CDD:188093
		EGF_CA	963..1001	CDD:238011
		EGF_CA	1005..1038	CDD:238011
		EGF_CA	1042..1079	CDD:238011
		EGF_CA	1081..1117	CDD:238011
		EGF	1130..1160	CDD:333761
		LamG	1188..1321	CDD:214598
		EGF	1379..1407	CDD:333761
		GHB_like	<1473..1528	CDD:389804
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910