DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment scrib and RSU1

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	NP_036557.1	Gene:	RSU1 / 6251	HGNCID:	10464	Length:	277	Species:	Homo sapiens

Alignment Length:	294	Identity:	95/294 - (32%)
Similarity:	135/294 - (45%)	Gaps:	47/294 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   150 SLTQLESLELRENLLKHLPETISQLTKLKRLDLGDNEIEDLPPYLGY--LPGLHELWLDHNQLQR 212
            ||.:|    :.|:..|:.||          :|:.|..|.::....|.  |..:.:|.|.||:|..
Human     4 SLKKL----VEESREKNQPE----------VDMSDRGISNMLDVNGLFTLSHITQLVLSHNKLTM 54

  Fly   213 LPPELGLLTKLTYLDVSENRLEELPNEISGLVSLTDLDLAQNLLEALPDGIAKLSRLTILKLDQN 277
            :||.:..|..|..|:...|::||||.:||.|..|..|:|..|.|..||.|...|..|.:|.|..|
Human    55 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYN 119

  Fly   278 RLQRLNDTLGNCENMQELILTENFLSELPASIGQMTKLNNLNVDRNALEYLPLEIGQCANLGVLS 342
            .                  |:||   .||.:...:|.|..|.:..|..|.||.:||:...|.:||
Human   120 N------------------LSEN---SLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILS 163

  Fly   343 LRDNKLKKLPPELGNCTVLHVLDVSGNQLLYLPYSLVNLQL---KAVWLSENQSQPLLTFQPDTD 404
            ||||.|..||.|:|..|.|..|.:.||:|..||..|.||.|   |.|:.:||  .|.:|  |..|
Human   164 LRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQVFKAEN--NPWVT--PIAD 224

  Fly   405 A-ETGEQVLSCYLLPQQEYQPITPARDLESDSEP 437
            . :.|...:..|:  :.|.......|.::::.||
Human   225 QFQLGVSHVFEYI--RSETYKYLYGRHMQANPEP 256

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064	43/134 (32%)
		leucine-rich repeat	18..38	CDD:275380
		LRR_8	37..95	CDD:290566
		leucine-rich repeat	39..61	CDD:275380
		leucine-rich repeat	62..84	CDD:275380
		LRR_8	84..138	CDD:290566
		leucine-rich repeat	85..107	CDD:275380
		leucine-rich repeat	108..130	CDD:275380
		LRR_8	129..187	CDD:290566	9/36 (25%)
		leucine-rich repeat	131..153	CDD:275380	2/2 (100%)
		leucine-rich repeat	154..176	CDD:275380	5/21 (24%)
		leucine-rich repeat	177..199	CDD:275380	5/23 (22%)
		LRR_8	198..256	CDD:290566	22/57 (39%)
		leucine-rich repeat	200..222	CDD:275380	8/21 (38%)
		leucine-rich repeat	223..245	CDD:275380	10/21 (48%)
		LRR_8	267..325	CDD:290566	13/57 (23%)
		leucine-rich repeat	269..289	CDD:275380	4/19 (21%)
		leucine-rich repeat	292..314	CDD:275380	5/21 (24%)
		leucine-rich repeat	315..337	CDD:275380	8/21 (38%)
		LRR_4	337..375	CDD:289563	18/37 (49%)
		leucine-rich repeat	361..382	CDD:275380	9/20 (45%)
		PDZ	728..816	CDD:214570
		PDZ_signaling	931..1016	CDD:238492
		PDZ	1239..1329	CDD:214570
		PDZ_signaling	1336..1425	CDD:238492
RSU1	NP_036557.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24		8/33 (24%)
		leucine-rich repeat	19..41	CDD:275380	6/31 (19%)
		PLN00113	34..>200	CDD:215061	67/186 (36%)
		LRR 1	41..63		7/21 (33%)
		leucine-rich repeat	42..64	CDD:275380	8/21 (38%)
		LRR 2	64..85		9/20 (45%)
		leucine-rich repeat	65..87	CDD:275380	10/21 (48%)
		LRR 3	87..109		8/21 (38%)
		leucine-rich repeat	88..110	CDD:275380	9/21 (43%)
		LRR 4	110..133		9/43 (21%)
		leucine-rich repeat	111..135	CDD:275380	9/44 (20%)
		LRR 5	135..156		8/20 (40%)
		leucine-rich repeat	136..158	CDD:275380	8/21 (38%)
		LRR 6	158..179		12/20 (60%)
		leucine-rich repeat	159..181	CDD:275380	12/21 (57%)
		LRR 7	181..202		8/20 (40%)
		leucine-rich repeat	182..207	CDD:275380	11/24 (46%)
		leucine-rich repeat	208..227	CDD:275380	8/22 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	250..277		2/7 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910