DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scrib and Erbin

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	NP_001005868.1	Gene:	Erbin / 59079	MGIID:	1890169	Length:	1450	Species:	Mus musculus

Alignment Length:	1601	Identity:	435/1601 - (27%)
Similarity:	678/1601 - (42%)	Gaps:	346/1601 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KCIPIFKGCNRQVEFVDKRHCSLPQVPEEILRYSRTLEELFLDANHIRDLPKNFFRLHRLRKLGL 67
            :|:   :|....|..:|..||||.|||:||..:.:|||||:||||.|.:|||..|....|.||.|
Mouse    15 RCL---RGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSL 76

  Fly    68 SDNEIGRLPPDIQNFENLVELDVSRNDIPDIPDDIKHLQSLQVADFSSNPIPKLPSGFSQLKNLT 132
            .||::..||..|.|..||.|||||:|.|.:.|::||:.:.|.:.:.|.|||.|||.|||||.|||
Mouse    77 PDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLT 141

  Fly   133 VLGLNDMSLTTLPADFGSLTQLESLELRENLLKHLPETISQLTKLKRLDLGDNEIEDLPPYLGYL 197
            .|.|||..|..|||:||.||:|:.||||||.||.||:|:::||:|:|||||.||..::|..|..|
Mouse   142 QLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQL 206

  Fly   198 PGLHELWLDHNQLQRLPPELGLLTKLTYLDVSENRLEELPNEISGLVSLTDLDLAQNLLEALPDG 262
            .||.|.|:|.|:|..:|..:|.|.:|||||||:|.:|.:...||...:|.|..|:.|.|:.||:.
Mouse   207 SGLREFWMDGNRLTFIPGFIGSLRQLTYLDVSKNNIEMVEEGISTCENLQDFLLSSNSLQQLPET 271

  Fly   263 IAKLSRLTILKLDQNRLQRLNDTLGNCENMQELILTENFLSELPASIGQMTKLNNLNVDRNALEY 327
            |..|..:|.||:|:|:|..|.|::|...:::||..:.|.:..||:||||:|.:.....|.|.|:.
Mouse   272 IGSLKNVTTLKIDENQLMYLPDSIGGLRSIEELDCSFNEIEALPSSIGQLTNMRTFAADHNYLQQ 336

  Fly   328 LPLEIGQCANLGVLSLRDNKLKKLPPELGNCTVLHVLDVSGNQLLYLPYSLVNL-QLKAVWLSEN 391
            ||.|||...|:.||.|..|||:.||.|:|:...|.|:::|.|:|..||:|...| ||.|:|||:|
Mouse   337 LPPEIGNWKNITVLFLHCNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDN 401

  Fly   392 QSQPLLTFQPDTDAETGEQVLSCYLLPQQEYQPITPARDLESDSEPF-----EEREPSRTVVKFS 451
            ||:||:..|.:||.||.:.||:.|:.||   ||.|......||:|.|     ||:...|..|.|.
Mouse   402 QSKPLIPLQKETDTETQKMVLTNYMFPQ---QPRTEDVMFISDNESFNPALWEEQRKQRAQVAFE 463

  Fly   452 -EEATQEKETP-----FVRQNTPHPKDLK--AKAQKLKVERSRNEEHANLVTLPEENGTKLAETP 508
             :|...|:|.|     ..|..||:|.:||  .|..:..|.|.::||      ..||:|..|.:
Mouse   464 CDEDKDEREAPPREGNLKRYPTPYPDELKNMVKTVQTIVHRLKDEE------TNEESGRDLKQ-- 520

  Fly   509 TETRTIANNHQQQPHPVQQPIVGVNSKQPVVVGVVTPTTTTVAP-----TGVQGGSEGASSTANN 568
                          |..||.   ||..:.|.....|.|.:.:..     ..||..||..:.|...
Mouse   521 --------------HEDQQV---VNKDKCVKTSESTTTKSKLDEREKYMNSVQKMSEPEAETNGG 568

  Fly   569 VKAATAAVVAELAATVGGSDEVQDDD--EQEDEFESDRRVGFQVEGEDDDFYKRPPKLHRRDTPH 631
            ....||::  :|:..:  ...|..||  |:.:|..||..:...        ..|||
Mouse   569 NLPVTASM--KLSGNL--KHIVNHDDVFEESEELSSDEEMKMA--------EMRPP--------- 612

  Fly   632 HLKNKRVQHLTDKQASEILANALASQERNDTTPQHSLSGKVT----------------------- 673
                     |.:...::....||::.:::|.....|||.:||
Mouse   613 ---------LIESSINQPKVVALSNNKKDDAKDADSLSDEVTHNSNQNNSNCSSPSRMSDSVSLN 668

  Fly   674 ----------SPIEEEEQLEVEQEQQQQQQQHPFDSSL-SPISAGKTAEASTDPDNLDGVTELRL 727
                      ||:   :|..|:...:.:|:...|:|.| :.::...:.|   :...::...:.:|
Mouse   669 TDSSQDTSLCSPV---KQTPVDSNSKVRQEDENFNSLLQNGVNLNNSPE---EKFKINDKKDFKL 727

  Fly   728 EQYEIHIERTAAGLGLSIAGGKGSTPFKGDDDGIFISRVTEAGPADLAGLKVGDKVIKVNGIVVV 792
            .:|:::||.....:             :.|.|    |:.|......|..:.:....:..|.|...
Mouse   728 PEYDLNIEEQLVLI-------------EKDID----SKATSDDSRQLDHINMNINKLVTNNIFQP 775

  Fly   793 DADHYQAVQVLKACGAVLVLVVQREVTRLIGHPVFSEDGSVSQIS---VETRPLVADAPPAASIS 854
            :......:|.:......|.:..:.|...:.....|....|:::::   .:|.|......|..:.|
Mouse   776 EVMERSKMQDIVLGTGFLSIHPKNEAEHIENGAKFPNLESINKVNGLCEDTAPSPGRVEPQKASS 840

  Fly   855 HERYIPAPIEIVPQQQHLQQQQQQPIQQVAPTHSYSGNVFATPTAAQTVQPAVSAAPNGLLL--- 916
                 .|.:.|....:.|..|:..|...|..:||.        |..:|         .||.:
Mouse   841 -----SADVGISKSTEDLSPQRSGPTGAVVKSHSI--------TNMET---------GGLKIYDI 883

  Fly   917 ---NGREAPLSYIQLHTTLIRDQIGQGLGFSIAGGKGSPPFKDDCDGIFISRITEGGLAYRDGKI 978
               :|.:.|.:.:::.:.:.        |.:|...|.:....|....:|.:       |....::
Mouse   884 LGDDGPQPPSAAVKIASAVD--------GKNIVRSKSATLLYDQPLQVFTA-------ASSSSEL 933

  Fly   979 MVGDR-VMAINGNDMTEAHHDAAVACLTEPQRFVRLVLQREY------------------RGPLE 1024
            :.|.: |...:.|...|.......|.::.||....|....:|                  :.|..
Mouse   934 LSGTKAVFKFDSNHNPEEPDIIRAATVSGPQSTPHLYGPPQYNVQYSGSATVKDTLWHPKQNPQI 998

  Fly  1025 PPTS------PRSPAVLNSLSPSGYLANRPANFSRSVVEVEQPYKYNTLATTT--PTPKPTVPA- 1080
            .|.|      |||.:..|. |.:.:.||  .|||          .:|.:...|  ...:...||
Mouse   999 DPVSFPPQRLPRSESAENH-SYAKHSAN--MNFS----------NHNNVRANTGYHLQQRLAPAR 1050

  Fly  1081 -----SISNNNNTLP--SSKTNGFATAAAATIDSSTGQPVPAPRRTNSVPMGDGDIGAGSTTSGD 1138
                 :||.|:..:|  :..|....::.::|...:.|.|.   |||....:...::.:...|...
Mouse  1051 HGEMWAISPNDRLVPAVTRTTIQRQSSVSSTASVNLGDPT---RRTEGDYLSYRELHSMGRTPVM 1112

  Fly  1139 SGEAQPSSLRPLTSDDFQAMIPAHFLSGGSQHQVHVARP--NEVGVSAVTV---NVNKPQP---- 1194
            ||..:|.|.|            |:.:.|.:..:...|||  ||:....::|   |.::..|
Mouse  1113 SGSQRPLSAR------------AYSIDGPNTSRPQSARPSINEIPERTMSVSDFNYSRTSPSKRP 1165

  Fly  1195 -----------DLPMFPAAPTELGRVTETITKSTFTETVMTRITDNQLAEPLISEEV-------- 1240
                       |.|.....|.:            :.|.|:..|...:|.:.::|...
Mouse  1166 NTRVGSEHSLLDPPGKSKVPHD------------WREQVLRHIEAKKLEKSMLSRSFNSNLTAVS 1218

  Fly  1241 --------VLPKNQGSLGFSIIGGTDHSCVPF---GTREPG------IFIS----HIVPGGIASK 1284
                    .|..:||||..|:..|.......|   .|..||      .|:|    |  |.|..|.
Mouse  1219 SSHYGSSRDLHGSQGSLALSVADGRGSGGHIFRHPQTSSPGECCQDDRFMSEEQNH--PSGALSH 1281

  Fly  1285 CGKLRMGDRILKV------------NEADVSKATHQDAVLELLKPG-----DEIKLTIQHDP--- 1329
            .|   :.|.::|:            .:|..|:..|.........|.     |.:.|.:.|.|
Mouse  1282 RG---LPDSLMKMPLSNGQMGQPLRPQAHYSQTHHPPQASVARHPSREQLIDYLMLKVAHQPPYT 1343

  Fly  1330 ---LPP------GFQEVLLSKAEGERLGMHIKGGLNGQRGNPADPSDEGVFVSKINSVGAARRDG 1385
               ..|      ..||:.:...:...||..|.||:.| ||||..|.|:|:||:::...|.|.:
Mouse  1344 HPHCSPRQGHELAKQEIRVRVEKDPELGFSISGGVGG-RGNPFRPDDDGIFVTRVQPEGPASK-- 1405

  Fly  1386 RLKVGMRLLEVNGHSLLGASHQDAVNVLRNAGNEIQLVVCK 1426
            .|:.|.::::.||:|.:...|..||::|:...|.:.|::.:
Mouse  1406 LLQPGDKIIQANGYSFINIEHGQAVSLLKTFHNAVDLIIVR 1446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064	136/269 (51%)
		leucine-rich repeat	18..38	CDD:275380	10/19 (53%)
		LRR_8	37..95	CDD:290566	32/57 (56%)
		leucine-rich repeat	39..61	CDD:275380	13/21 (62%)
		leucine-rich repeat	62..84	CDD:275380	10/21 (48%)
		LRR_8	84..138	CDD:290566	30/53 (57%)
		leucine-rich repeat	85..107	CDD:275380	11/21 (52%)
		leucine-rich repeat	108..130	CDD:275380	13/21 (62%)
		LRR_8	129..187	CDD:290566	36/57 (63%)
		leucine-rich repeat	131..153	CDD:275380	13/21 (62%)
		leucine-rich repeat	154..176	CDD:275380	13/21 (62%)
		leucine-rich repeat	177..199	CDD:275380	11/21 (52%)
		LRR_8	198..256	CDD:290566	25/57 (44%)
		leucine-rich repeat	200..222	CDD:275380	9/21 (43%)
		leucine-rich repeat	223..245	CDD:275380	11/21 (52%)
		LRR_8	267..325	CDD:290566	21/57 (37%)
		leucine-rich repeat	269..289	CDD:275380	9/19 (47%)
		leucine-rich repeat	292..314	CDD:275380	9/21 (43%)
		leucine-rich repeat	315..337	CDD:275380	8/21 (38%)
		LRR_4	337..375	CDD:289563	16/37 (43%)
		leucine-rich repeat	361..382	CDD:275380	9/21 (43%)
		PDZ	728..816	CDD:214570	12/87 (14%)
		PDZ_signaling	931..1016	CDD:238492	14/85 (16%)
		PDZ	1239..1329	CDD:214570	27/135 (20%)
		PDZ_signaling	1336..1425	CDD:238492	29/88 (33%)
Erbin	NP_001005868.1	leucine-rich repeat	24..47	CDD:275380	11/22 (50%)
		LRR_RI	<48..209	CDD:238064	88/160 (55%)
		leucine-rich repeat	48..70	CDD:275380	13/21 (62%)
		LRR	70..418	CDD:227223	167/347 (48%)
		leucine-rich repeat	71..93	CDD:275380	10/21 (48%)
		leucine-rich repeat	94..116	CDD:275380	11/21 (52%)
		leucine-rich repeat	117..139	CDD:275380	13/21 (62%)
		LRR_RI	<130..314	CDD:238064	89/183 (49%)
		leucine-rich repeat	140..162	CDD:275380	13/21 (62%)
		leucine-rich repeat	163..185	CDD:275380	13/21 (62%)
		leucine-rich repeat	186..208	CDD:275380	11/21 (52%)
		leucine-rich repeat	209..231	CDD:275380	9/21 (43%)
		leucine-rich repeat	278..300	CDD:275380	9/21 (43%)
		leucine-rich repeat	301..323	CDD:275380	9/21 (43%)
		leucine-rich repeat	347..369	CDD:275380	10/21 (48%)
		LRR_4	368..411	CDD:289563	20/42 (48%)
		leucine-rich repeat	370..390	CDD:275380	8/19 (42%)
		PDZ_signaling	1359..1445	CDD:238492	29/88 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BA7S
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D148064at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820