DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scrib and Pdzk1

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	NP_001139473.1	Gene:	Pdzk1 / 59020	MGIID:	1928901	Length:	519	Species:	Mus musculus

Alignment Length:	788	Identity:	137/788 - (17%)
Similarity:	242/788 - (30%)	Gaps:	354/788 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly   757 DDDGIFISRVTEAGPADLAGLKVGDKVIKVNGIVVVDADHYQAVQVLKACGAVLVLVVQREVTRL 821
            |.||..|..:.|..||:.|||..||:|:::||:.|...:|.|.|::::..|..:.|:|.
Mouse    29 DTDGHLIRVIEEGSPAEKAGLLDGDRVLRINGVFVDKEEHAQVVELVRKSGNSVTLLVL------ 87

  Fly   822 IGHPVFSEDGSVSQISVETRPLVADAPPAASISHERYIPAPIEIVPQQQHLQQQQQQPIQQVAPT 886
                    ||.                     |:|:.:...:::    :.|.|.|:
Mouse    88 --------DGD---------------------SYEKAVKNQVDL----KELDQSQR--------- 110

  Fly   887 HSYSGNVFATPTAAQTVQPAVSAAPNGLLLNGREAPLSYIQLHTTLIRDQIGQGLGFSIAGGKGS 951
                             :.|::....|..:||...|.:..:| ..|:::  |...|||:...:|.
Mouse   111 -----------------EAALNDKKPGPGMNGAVEPCAQPRL-CYLVKE--GNSFGFSLKTIQGK 155

  Fly   952 PPFKDDCDGIFISRITEGGLAYRDGKIMVGDRVMAINGNDMTEAHHDAAVACLTEP-QRFVRLVL 1015
                   .|::::.|...|:|.:.| ::..|.::.:||.::..|.|:..|..:|:. .|.:.|::
Mouse   156 -------KGVYLTNIMPQGVAMKAG-VLADDHLIEVNGENVENASHEEVVEKVTKSGSRIMFLLV 212

  Fly  1016 QREYRGPLEPPTSPRSPAVLNSLSPSGYLANRPANFSRSVVEVEQPYKYNTLATTTPTPKPTVPA 1080
            .:|                                .:|...|.:..:|..|
Mouse   213 DKE--------------------------------TARCHSEQKTQFKRET-------------- 231

  Fly  1081 SISNNNNTLPSSKTNGFATAAAATIDSSTGQPVPAPRRTNSVPMGDGDIGAGSTTSGDSGEAQPS 1145
                                                                            :
Mouse   232 ----------------------------------------------------------------A 232

  Fly  1146 SLRPLTSDDFQAMIPAHFLSGGSQHQVHVARPNEVGVSAVTVNVNKPQPDLPMFPAAPTELGRVT 1210
            ||:         ::|         ||..|
Mouse   233 SLK---------LLP---------HQPRV------------------------------------ 243

  Fly  1211 ETITKSTFTETVMTRITDNQLAEPLISEEVVLPKNQGSLGFSIIGGTDHSCVPFGTREPGIFISH 1275
                                         ||:.|.....||.:..|.:         :.|..|..
Mouse   244 -----------------------------VVIKKGSNGYGFYLRAGPE---------QKGQIIKD 270

  Fly  1276 IVPGGIASKCGKLRMGDRILKVNEADVSKATHQDAVLELL-KPGDEIKL---------------- 1323
            |.||..|...| |:..|.::.||...|....| |.|:|:: |.||:..|
Mouse   271 IEPGSPAEAAG-LKNNDLVVAVNGKSVEALDH-DGVVEMIRKGGDQTTLLVLDKEAESIYSLARF 333

  Fly  1324 --------------TIQHDPLP-PGFQEVLLSK----AEGER------------LGMHIKGGLNG 1357
                          :::..|.| |...|...|:    |||.:            .|.|    ||.
Mouse   334 SPLLYCQSQELPNGSVKEGPAPIPAPLEATGSEPTEDAEGHKPKLCRLLKEDDSYGFH----LNA 394

  Fly  1358 QRGNPADPSDEGVFVSKINSVGAARRDGRLKVGMRLLEVNGHSLLGASHQDAVNVLRNAGNEIQL 1422
            .||.|      |.||.::...|.|.:.| |:....::||||.::....:...|..::::|..:.|
Mouse   395 IRGQP------GSFVKEVQQGGPADKAG-LENEDVIIEVNGENVQEEPYDRVVERIKSSGKHVTL 452

  Fly  1423 VVCKGYDKSNLIHSIGQAGGMSTGFNSSAS--CSGGSRQG--SRASETGSELSQSQSVSSLDH-- 1481
            :||     ..:.:|..||..:.. .:|.|.  .:|...:|  |..||..:..::.:::|:..|
Mouse   453 LVC-----GKMAYSYFQAKKIPI-VSSMAEPLVAGPDEKGETSAESEHDAHPAKDRTLSTASHSS 511

  Fly  1482 --EEDERL 1487
              .||..:
Mouse   512 SNSEDTEM 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064
		leucine-rich repeat	18..38	CDD:275380
		LRR_8	37..95	CDD:290566
		leucine-rich repeat	39..61	CDD:275380
		leucine-rich repeat	62..84	CDD:275380
		LRR_8	84..138	CDD:290566
		leucine-rich repeat	85..107	CDD:275380
		leucine-rich repeat	108..130	CDD:275380
		LRR_8	129..187	CDD:290566
		leucine-rich repeat	131..153	CDD:275380
		leucine-rich repeat	154..176	CDD:275380
		leucine-rich repeat	177..199	CDD:275380
		LRR_8	198..256	CDD:290566
		leucine-rich repeat	200..222	CDD:275380
		leucine-rich repeat	223..245	CDD:275380
		LRR_8	267..325	CDD:290566
		leucine-rich repeat	269..289	CDD:275380
		leucine-rich repeat	292..314	CDD:275380
		leucine-rich repeat	315..337	CDD:275380
		LRR_4	337..375	CDD:289563
		leucine-rich repeat	361..382	CDD:275380
		PDZ	728..816	CDD:214570	22/58 (38%)
		PDZ_signaling	931..1016	CDD:238492	20/85 (24%)
		PDZ	1239..1329	CDD:214570	26/120 (22%)
		PDZ_signaling	1336..1425	CDD:238492	26/104 (25%)
Pdzk1	NP_001139473.1	PDZ_signaling	7..87	CDD:238492	21/57 (37%)
		PDZ	132..212	CDD:214570	21/90 (23%)
		PDZ_signaling	242..320	CDD:238492	27/153 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	348..374		7/25 (28%)
		PDZ_signaling	376..455	CDD:238492	21/89 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	479..519		9/39 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910