DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment scrib and LRRC7

DIOPT Version :9

Sequence 1:NP_001163746.1 Gene:scrib / 44448 FlyBaseID:FBgn0263289 Length:2585 Species:Drosophila melanogaster
Sequence 2:NP_001357714.1 Gene:LRRC7 / 57554 HGNCID:18531 Length:1575 Species:Homo sapiens


Alignment Length:1663 Identity:458/1663 - (27%)
Similarity:673/1663 - (40%) Gaps:394/1663 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 FKGCNRQVEFVDKRHCSLPQVPEEILRYSRTLEELFLDANHIRDLPKNFFRLHRLRKLGLSDNEI 72
            |:|....:..:|..||||.|||:|:..:.||||||:||||.|.:|||..|....||||.:.||::
Human    55 FRGEEEIISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDL 119

  Fly    73 GRLPPDIQNFENLVELDVSRNDIPDIPDDIKHLQSLQVADFSSNPIPKLPSGFSQLKNLTVLGLN 137
            ..||..|.:..||.|||:|:|.:.:.|::||..:.|.:.:.|.|||.|||.||:||.|||.|.||
Human   120 SNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLN 184

  Fly   138 DMSLTTLPADFGSLTQLESLELRENLLKHLPETISQLTKLKRLDLGDNEIEDLPPYLGYLPGLHE 202
            |..|..|||:||.|.:|..||||||.||.||:::.:|.:|:|||||:||..:||..|..:..|.|
Human   185 DAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLRE 249

  Fly   203 LWLDHNQLQRLPPELGLLTKLTYLDVSENRLEELPNEISGLVSLTDLDLAQNLLEALPDGIAKLS 267
            ||:|:|.||.||..:|.|..|.|||:|:||:|.:..:|||..:|.||.|:.|:|:.|||.|..|.
Human   250 LWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLK 314

  Fly   268 RLTILKLDQNRLQRLNDTLGNCENMQELILTENFLSELPASIGQMTKLNNLNVDRNALEYLPLEI 332
            :||.||:|.|:|..|.:|:||...::|...:.|.|..||::||.:..|..|.||.|.|..||.||
Human   315 KLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREI 379

  Fly   333 GQCANLGVLSLRDNKLKKLPPELGNCTVLHVLDVSGNQLLYLPYSLVNL-QLKAVWLSENQSQPL 396
            |.|.|:.|:|||.|||:.||.|:|....|.||::|.|:|..||:|...| :|.|:|||:|||:.|
Human   380 GSCKNVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQSKAL 444

  Fly   397 LTFQPDTDAETGEQVLSCYLLPQQEYQPITPA--RDLESDSEPF-----EEREPSRTVVKFSEEA 454
            :..|.:...||.::||:.|:.|||      |.  .|.:|||:.|     ||:...|..|.|..|.
Human   445 IPLQTEAHPETKQRVLTNYMFPQQ------PRGDEDFQSDSDSFNPTLWEEQRQQRMTVAFEFED 503

  Fly   455 TQEKE----------------------------------TPFVR-----QNTPHPKDLKAKA--- 477
            .:|.:                                  ||:.|     |:.|.|::....|   
Human   504 KKEDDENAGKVKDLSCQAPWERGQRGITLQPARLSGDCCTPWARCDQQIQDMPVPQNDPQLAWGC 568

  Fly   478 -QKLKVERSRNEE---HANLVTLPEENGTKLAETPTETRTIANNHQQQPHPVQQPIVGVNSKQPV 538
             ..|:.|||....   .|...|||..:|          |.:..|.::.|.|..:.:..:......
Human   569 ISGLQQERSMCTPLPVAAQSTTLPSLSG----------RQVEINLKRYPTPYPEDLKNMVKSVQN 623

  Fly   539 VVGVVTPTTTTVAPT-GVQGGSEGASSTANNVKAATAAV-----VAELAATVGGSDEVQDDDEQE 597
            :||         .|: ||:  .|.::.|||..:......     ||....||            |
Human   624 LVG---------KPSHGVR--VENSNPTANTEQTVKEKYEHKWPVAPKEITV------------E 665

  Fly   598 DEF---ESDRRVG-FQVEGEDDDFYKRPPKLHRRDTPHHLKNKRVQHLTDKQASEI-----LANA 653
            |.|   .::.|:| ......:...|  ||||       .|..|..:..||:  ||:     |.|:
Human   666 DSFVHPANEMRIGELHPSLAETPLY--PPKL-------VLLGKDKKESTDE--SEVDKTHCLNNS 719

  Fly   654 LASQERNDTTPQHSLSGKVTSPIEEEEQLEVEQEQQQQQQ---------QHPFDSS--LSPISAG 707
            ::|...:|.:|..:.||...:.::........::......         ..|.||.  ||...|.
Human   720 VSSGTYSDYSPSQASSGSSNTRVKVGSLQTTAKDAVHNSLWGNRIAPSFPQPLDSKPLLSQREAV 784

  Fly   708 KTAEASTDPDNL-------DGVTELRLEQYEIHIERTAAGLGLSIAGGKGSTPFKGDDDGIFISR 765
            ........||.|       |..|:      ..|.:.|......:.|....|.|.....     ||
Human   785 PPGNIPQRPDRLPMSDTFTDNWTD------GSHYDNTGFVAEETTAENANSNPLLSSK-----SR 838

  Fly   766 VTEA-GPADLAGLKVGDKVIKVNGIVVVDADHYQAVQVLKACGAVLVLVVQREV---------TR 820
            .|.: |...|         |:.:.||.|..:..|:..         ....:.||         ||
Human   839 STSSHGRRPL---------IRQDRIVGVPLELEQSTH---------RHTPETEVPPSNPWQNWTR 885

  Fly   821 LIGHPVFSEDGSVSQISVETRPLVADAPPAAS-ISHERYIPAPIEI-VPQQQHLQQQQQQPIQQV 883
            .   |...||.:.....:||.|..:..|.... |.....||:|... ||.:.|    ...|.:.:
Human   886 T---PSPFEDRTAFPSKLETTPTTSPLPERKEHIKESTEIPSPFSPGVPWEYH----DSNPNRSL 943

  Fly   884 APTHSY-------SGNVFATPTAAQTVQPAVSAAPNGLLLNGR---EAPLSYIQLHTTLIRD--- 935
            :...|.       |..|.:...:.:.:.|.:....:......:   |..:...:::...:.:   
Human   944 SNVFSQIHCRPESSKGVISISKSTERLSPLMKDIKSNKFKKSQSIDEIDIGTYKVYNIPLENYAS 1008

  Fly   936 -------------QIGQGLGFSIAGGKGSPPFKDDCDGIFISRITEGG-------LAYRDGKIMV 980
                         .:|...|.|......|.|..||      ..:|.|.       .|....|:..
Human  1009 GSDHLGSHERPDKMLGPEHGMSSMSRSQSVPMLDD------EMLTYGSSKGPQQQKASMTKKVYQ 1067

  Fly   981 GDRVMAINGNDMTEAHHDAAVACLTEPQRFVR---------LVLQREYRG--PLEPPTSPRSP-- 1032
            .|:.....|:...:|...........|: :|:         |:..|.|||  |:|...|...|  
Human  1068 FDQSFNPQGSVEVKAEKRIPPPFQHNPE-YVQQASKNIAKDLISPRAYRGYPPMEQMFSFSQPSV 1131

  Fly  1033 ---AVLNSLSPS-----GYL--------ANRPANFSRSVVEVEQPYKYNTLATTTPTPKPTVPAS 1081
               ||:|:...|     |:|        |...|.|.|    |.:|::   |..|....:|.....
Human  1132 NEDAVVNAQFASQGARAGFLRRADSLVSATEMAMFRR----VNEPHE---LPPTDRYGRPPYRGG 1189

  Fly  1082 ISNNNN-TLPSS---KTNGFATAAAATIDSSTGQ--PVPAPRRTNSVPMGDGDIGAGSTTSGDSG 1140
            :...:: |:..|   |.||.......:......|  ..|....|...|:   ...:.||.|..:.
Human  1190 LDRQSSVTVTESQFLKRNGRYEDEHPSYQEVKAQAGSFPVKNLTQRRPL---SARSYSTESYGAS 1251

  Fly  1141 EAQPSSLRPLTSDDFQAMIPAHFLSGG-----SQHQVHVARPNEV-GVSAV-------------- 1185
            :.:|.|.|| |.......||:.:..|.     |.:.....||..| |..:.              
Human  1252 QTRPVSARP-TMAALLEKIPSDYNLGNYGDKPSDNSDLKTRPTPVKGEESCGKMPADWRQQLLRH 1315

  Fly  1186 ---------------TVNVNKPQPDLPMFPAAPTELGR-VTETI-TKSTF---------TETVMT 1224
                           |||:..    ||....:....|| :|..: |||.|         |.:..:
Human  1316 IEARRLDRNAAYKHNTVNLGM----LPYGGISAMHAGRSMTLNLQTKSKFDHQELPLQKTPSQQS 1376

  Fly  1225 RITDNQLAEPLISEEVVLPKNQGSLGFSIIGGTDHSCVPFGTREPGIFISHIVPGGIASKCG--- 1286
            .|.||       .:|.|.|..|            .:..|.|.|:       :.|..|..|.|   
Human  1377 NILDN-------GQEDVSPSGQ------------WNPYPLGRRD-------VPPDTITKKAGSHI 1415

  Fly  1287 KLRMGDRILKVNEADVSKATHQDAVLELLKPGDEIKLTIQ--HDPLP---PGFQEV-------LL 1339
            :..||.:.|:      .::..|...     .|:..|:|||  ..|||   |..|..       .|
Human  1416 QTLMGSQSLQ------HRSREQQPY-----EGNINKVTIQQFQSPLPIQIPSSQATRGPQPGRCL 1469

  Fly  1340 SKAEGER------------------LGMHIKGGLNGQRGNPADPSDEGVFVSKINSVGAARRDGR 1386
            .:.:|:|                  ||..|.||::|| |||..|||:|:||:::...|.|  ...
Human  1470 IQTKGQRSMDGYPEQFCVRIEKNPGLGFSISGGISGQ-GNPFKPSDKGIFVTRVQPDGPA--SNL 1531

  Fly  1387 LKVGMRLLEVNGHSLLGASHQDAVNVLRNAGNEIQLVV 1424
            |:.|.::|:.||||.:...|:.||.:|::..|.:.||:
Human  1532 LQPGDKILQANGHSFVHMEHEKAVLLLKSFQNTVDLVI 1569

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
scribNP_001163746.1 LRR_RI 13..283 CDD:238064 133/269 (49%)
leucine-rich repeat 18..38 CDD:275380 9/19 (47%)
LRR_8 37..95 CDD:290566 31/57 (54%)
leucine-rich repeat 39..61 CDD:275380 13/21 (62%)
leucine-rich repeat 62..84 CDD:275380 9/21 (43%)
LRR_8 84..138 CDD:290566 27/53 (51%)
leucine-rich repeat 85..107 CDD:275380 9/21 (43%)
leucine-rich repeat 108..130 CDD:275380 12/21 (57%)
LRR_8 129..187 CDD:290566 33/57 (58%)
leucine-rich repeat 131..153 CDD:275380 13/21 (62%)
leucine-rich repeat 154..176 CDD:275380 12/21 (57%)
leucine-rich repeat 177..199 CDD:275380 11/21 (52%)
LRR_8 198..256 CDD:290566 28/57 (49%)
leucine-rich repeat 200..222 CDD:275380 12/21 (57%)
leucine-rich repeat 223..245 CDD:275380 11/21 (52%)
LRR_8 267..325 CDD:290566 23/57 (40%)
leucine-rich repeat 269..289 CDD:275380 10/19 (53%)
leucine-rich repeat 292..314 CDD:275380 7/21 (33%)
leucine-rich repeat 315..337 CDD:275380 12/21 (57%)
LRR_4 337..375 CDD:289563 18/37 (49%)
leucine-rich repeat 361..382 CDD:275380 10/21 (48%)
PDZ 728..816 CDD:214570 15/88 (17%)
PDZ_signaling 931..1016 CDD:238492 17/116 (15%)
PDZ 1239..1329 CDD:214570 20/94 (21%)
PDZ_signaling 1336..1425 CDD:238492 35/114 (31%)
LRRC7NP_001357714.1 leucine-rich repeat 64..85 CDD:275380 9/20 (45%)
LRR_8 85..140 CDD:338972 29/54 (54%)
leucine-rich repeat 86..108 CDD:275380 13/21 (62%)
leucine-rich repeat 109..131 CDD:275380 9/21 (43%)
LRR 130..440 CDD:227223 150/309 (49%)
leucine-rich repeat 132..177 CDD:275380 21/44 (48%)
leucine-rich repeat 178..200 CDD:275380 13/21 (62%)
leucine-rich repeat 201..223 CDD:275380 12/21 (57%)
leucine-rich repeat 224..246 CDD:275380 11/21 (52%)
leucine-rich repeat 247..269 CDD:275380 12/21 (57%)
leucine-rich repeat 270..292 CDD:275380 11/21 (52%)
leucine-rich repeat 316..336 CDD:275380 10/19 (53%)
leucine-rich repeat 339..361 CDD:275380 7/21 (33%)
leucine-rich repeat 362..384 CDD:275380 12/21 (57%)
leucine-rich repeat 385..407 CDD:275380 11/21 (52%)
leucine-rich repeat 408..430 CDD:275380 10/21 (48%)
PDZ_signaling 1485..1570 CDD:238492 32/88 (36%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D148064at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.920

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