DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment scrib and si:ch211-176g6.2

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	XP_009304643.1	Gene:	si:ch211-176g6.2 / 572157	ZFINID:	ZDB-GENE-121214-224	Length:	1069	Species:	Danio rerio

Alignment Length:	517	Identity:	93/517 - (17%)
Similarity:	143/517 - (27%)	Gaps:	230/517 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly   339 GVLSLRDNKLKKLPPELGNCTVLHVLDVSGNQLLYLPYSLVNLQLKAVWLSENQSQPLLT----- 398
            |:..|..:.|.||      .:.:::|......||.:.:|.:.|:..|  |:..|...||:
Zfish   726 GLSDLAQHFLLKL------SSAVNLLATPRETLLQMSWSALRLEYPA--LNAAQLHHLLSQYEPQ 782

  Fly   399 --------FQPDTDAE-----TGEQVLSCYLLPQQEYQPITPARDLESDSEPFEEREPSRTVVKF 450
                    :.|.||.|     |...:|.|:..|        |...|..|..|.   :.:|.|...
Zfish   783 RRCKHTCCWTPPTDTESCAAHTTADLLECFDAP--------PPLVLPGDGFPL---QLNRAVTDL 836

  Fly   451 S------------------EEATQEKETPFVRQNTPHPKD--LKAKAQKLKVERSRNEEHANLVT 495
            |                  |.||....||      ||...  ::||..||||
Zfish   837 SLIQSLQLLQKRIQNITDPESATAHTHTP------PHVSAVVMEAKRTKLKV------------- 882

  Fly   496 LPEENGTKLAETPTETRTIANNHQQQPHPVQQPIVGVNSKQPVVVGVVTPTTTTVAPTGVQGGSE 560
                        |.:.|...:.|.:...|......|                            :
Zfish   883 ------------PPKARLEPSGHSELQFPPDLDSCG----------------------------D 907

  Fly   561 GASSTANNVKAATAAVVAELAATVGGSDEVQDDDEQEDEFESDRRVGFQVEGEDDDFYKRPPKLH 625
            ..|.|..|:                   |:||:|.             .|...|......||
Zfish   908 LLSQTLQNL-------------------ELQDEDG-------------SVAALDSSCLLTPP--- 937

  Fly   626 RRDTPHHLKNKRVQHLTDKQASEILANALASQERNDTTPQHSLSGKVTSPIEEEEQLEVEQEQQQ 690
              :||...::       |.:.||....|:...|..|.
Zfish   938 --NTPRQTED-------DAEQSECNEAAVGDDEDEDV---------------------------- 965

  Fly   691 QQQQHPFDSSLSPISAGKTAEASTDPDNLDGVTELRLEQYEIHIERTAAGLGLSIAGGKGSTPFK 755
                                                   :.:.::|.|.||||.:..|:.:...
Zfish   966 ---------------------------------------FVLELQRAACGLGLLLVDGEETAGL- 990

  Fly   756 GDDDGIFISRVTEAGPADLA-GLKVGDKVIKVNGIVVVDADHYQAVQVLKACGAVLVLVVQR 816
             ...||||..:....||.|: .||.||:::.|||..:...|:...:.:::..|....|:|.|
Zfish   991 -GVSGIFIKSILPDSPAALSERLKSGDRILAVNGKSLSGVDYQTGMDLIQTSGERPRLLVSR 1051

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064
		leucine-rich repeat	18..38	CDD:275380
		LRR_8	37..95	CDD:290566
		leucine-rich repeat	39..61	CDD:275380
		leucine-rich repeat	62..84	CDD:275380
		LRR_8	84..138	CDD:290566
		leucine-rich repeat	85..107	CDD:275380
		leucine-rich repeat	108..130	CDD:275380
		LRR_8	129..187	CDD:290566
		leucine-rich repeat	131..153	CDD:275380
		leucine-rich repeat	154..176	CDD:275380
		leucine-rich repeat	177..199	CDD:275380
		LRR_8	198..256	CDD:290566
		leucine-rich repeat	200..222	CDD:275380
		leucine-rich repeat	223..245	CDD:275380
		LRR_8	267..325	CDD:290566
		leucine-rich repeat	269..289	CDD:275380
		leucine-rich repeat	292..314	CDD:275380
		leucine-rich repeat	315..337	CDD:275380
		LRR_4	337..375	CDD:289563	8/35 (23%)
		leucine-rich repeat	361..382	CDD:275380	4/20 (20%)
		PDZ	728..816	CDD:214570	25/88 (28%)
		PDZ_signaling	931..1016	CDD:238492
		PDZ	1239..1329	CDD:214570
		PDZ_signaling	1336..1425	CDD:238492
si:ch211-176g6.2	XP_009304643.1	RA	104..203	CDD:279168
		FHA	321..427	CDD:238017
		Myo5p-like_CBD_Rasip1	472..821	CDD:271256	24/110 (22%)
		PDZ_signaling	965..1049	CDD:238492	24/152 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910