DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment scrib and lrrc8c

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	NP_001313473.1	Gene:	lrrc8c / 571216	ZFINID:	ZDB-GENE-030131-2965	Length:	792	Species:	Danio rerio

Alignment Length:	351	Identity:	107/351 - (30%)
Similarity:	156/351 - (44%)	Gaps:	60/351 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 QVEFVDKRHCSLPQVPEEILRYSRTLEELFLDANHIRDLPKN-----FFRLHRLRKLGLSDNEIG 73
            :|:|.|.|  .|||    .|...|.||||.|..:...|..||     ...|..|:.|.|..| ..
Zfish   486 RVKFDDSR--ELPQ----WLYVLRNLEELHLIGSLGSDAAKNVTLDSLRELKALKTLTLKSN-FT 543

  Fly    74 RLPPDIQNFENLVELDVSRNDIPDIPDDIKHLQSLQVADFSSNPIPKLPSGFSQLKNLTVLGLND 138
            ::|..|        :||:           .|||.|.:.:..:..:  :.:...::.|||.|.|..
Zfish   544 KIPQSI--------VDVA-----------SHLQRLSICNDGTKLV--MLNNLKKMGNLTELELVH 587

  Fly   139 MSLTTLPADFGSLTQLESLELRENLLKHLPETIS--QLTKLKRLDLGDNEIEDLPPYLGYLPGLH 201
            ..|..:|....|||.|:.|:|:||.|:.:.|.:|  .|.||..|.|..|.|..:|.::..|..|.
Zfish   588 CDLERIPHAIFSLTNLQMLDLKENNLRSIEEILSFQHLRKLTCLKLWHNGIAFIPEHIKKLGSLE 652

  Fly   202 ELWLDHNQLQRLPPELGLLTKLTYLDVSENRLEELPNEISGLVSLTDLDLAQNLLEALPDGIAKL 266
            .|:|.||:::.||..|.|..||.|||||.|.:..:|.||..|.||....::.|.:|.:|
Zfish   653 RLYLSHNKIEILPSHLFLCNKLRYLDVSNNDIRFIPPEIGVLQSLQYFSVSCNKIENIP------ 711

  Fly   267 SRLTILKLDQNRLQRLNDTLGNCENMQELILTENFLSELPASIGQMTKLNNLNVDRNALEYLPLE 331
                             |.|..|:.::.|.|..|.||.|...|..::.|.:|.:..|..|.||.|
Zfish   712 -----------------DELFFCKKLKTLKLGRNMLSVLSPKISFLSVLTHLELKGNHFEILPAE 759

  Fly   332 IGQCANL--GVLSLRDNKLKKLPPEL 355
            :|.|..|  ..|::.|...:.||.::
Zfish   760 LGACCALKRSGLAVEDALFETLPSDI 785

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064	83/275 (30%)
		leucine-rich repeat	18..38	CDD:275380	6/19 (32%)
		LRR_8	37..95	CDD:290566	18/62 (29%)
		leucine-rich repeat	39..61	CDD:275380	9/26 (35%)
		leucine-rich repeat	62..84	CDD:275380	6/21 (29%)
		LRR_8	84..138	CDD:290566	11/53 (21%)
		leucine-rich repeat	85..107	CDD:275380	4/21 (19%)
		leucine-rich repeat	108..130	CDD:275380	1/21 (5%)
		LRR_8	129..187	CDD:290566	24/59 (41%)
		leucine-rich repeat	131..153	CDD:275380	8/21 (38%)
		leucine-rich repeat	154..176	CDD:275380	9/23 (39%)
		leucine-rich repeat	177..199	CDD:275380	7/21 (33%)
		LRR_8	198..256	CDD:290566	24/57 (42%)
		leucine-rich repeat	200..222	CDD:275380	9/21 (43%)
		leucine-rich repeat	223..245	CDD:275380	11/21 (52%)
		LRR_8	267..325	CDD:290566	13/57 (23%)
		leucine-rich repeat	269..289	CDD:275380	2/19 (11%)
		leucine-rich repeat	292..314	CDD:275380	7/21 (33%)
		leucine-rich repeat	315..337	CDD:275380	9/21 (43%)
		LRR_4	337..375	CDD:289563	5/21 (24%)
		leucine-rich repeat	361..382	CDD:275380
		PDZ	728..816	CDD:214570
		PDZ_signaling	931..1016	CDD:238492
		PDZ	1239..1329	CDD:214570
		PDZ_signaling	1336..1425	CDD:238492
lrrc8c	NP_001313473.1	Pannexin_like	1..326	CDD:289311
		leucine-rich repeat	435..457	CDD:275380
		leucine-rich repeat	458..481	CDD:275380
		LRR_RI	476..684	CDD:238064	74/225 (33%)
		leucine-rich repeat	482..501	CDD:275380	8/20 (40%)
		leucine-rich repeat	505..532	CDD:275380	9/26 (35%)
		leucine-rich repeat	533..555	CDD:275380	8/41 (20%)
		leucine-rich repeat	556..579	CDD:275380	3/24 (13%)
		LRR_8	579..638	CDD:290566	24/58 (41%)
		leucine-rich repeat	580..602	CDD:275380	8/21 (38%)
		leucine-rich repeat	603..627	CDD:275380	9/23 (39%)
		LRR_8	626..684	CDD:290566	25/57 (44%)
		leucine-rich repeat	628..650	CDD:275380	7/21 (33%)
		leucine-rich repeat	651..673	CDD:275380	9/21 (43%)
		leucine-rich repeat	674..696	CDD:275380	11/21 (52%)
		LRR_8	696..753	CDD:290566	18/79 (23%)
		leucine-rich repeat	697..719	CDD:275380	7/44 (16%)
		leucine-rich repeat	720..742	CDD:275380	7/21 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910