DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scrib and pidd1

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	XP_021326274.1	Gene:	pidd1 / 571033	ZFINID:	ZDB-GENE-081104-353	Length:	960	Species:	Danio rerio

Alignment Length:	827	Identity:	194/827 - (23%)
Similarity:	293/827 - (35%)	Gaps:	261/827 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 LPPDIQNFENLVE----LDVSRNDIPDIP-------DDIKHLQSLQVADFSSNPIPKLPSGFSQL 128
            |||.:.....|||    |||.|.....:|       :.::.||.|::.....
Zfish    87 LPPSVGLDGVLVEERLVLDVYRGGAEVLPVFWEFVQERMRGLQYLRLGSEDE------------- 138

  Fly   129 KNLTVLGLNDMSLTTLPADFGSLTQLESLELR------------ENLLKHLPETISQLTKLKRLD 181
                  |..:.:|..||    .||||.||.:|            ..||..||:::|.|:.|..||
Zfish   139 ------GALERALRVLP----RLTQLRSLAIRGCRFHDPQGDPLPGLLSSLPDSVSSLSLLVHLD 193

  Fly   182 LGDNEIEDLPPYLGYLPGLHELWLDHNQLQRLPPELGLLTKLTYLDVSENRLEELPNEISGLVSL 246
            |..|....||..|.....|.||.|.||.|..||..:|.|..|..:.:..|||.:||.::..|..|
Zfish   194 LSFNRFSSLPSCLLSFSHLSELLLCHNNLTTLPEGIGALASLRRVSLLGNRLVDLPQDLGLLCGL 258

  Fly   247 TDLDLAQNLLEALPDGIAKLSRLTILKLDQNRLQRLNDTLGNCENMQELILTENFLSELPASIGQ 311
            .:||::.||||.|||.:.:|..|..|:|..|||:.|.:|||:..::::|::..|.|..:|..:..
Zfish   259 EELDVSFNLLEKLPDELGQLQNLQRLELSNNRLRSLPETLGSLRSLRQLLIQSNDLRSVPDCLHS 323

  Fly   312 MTKLNNLNVDRNAL--EYLPLEIGQCANLGVLSLRDNKLKKLPPEL-------------GNCTVL 361
            :..|:.|:|..|.|  ...|..:.|...:    :.|:::    |||             ..|
Zfish   324 LPMLDKLDVRNNPLGRPPTPPPLAQLTPV----VEDSEI----PELHLGFNQHSFQVSPAGC--- 377

  Fly   362 HVLDVSGNQLLYLPYSLVNL--QL---------KAVWLSENQSQPLLTFQPD--TDAETGEQVLS 413
            ||....|.:||: |...|.:  ||         |.|||.|:  ..||:.|.:  ....|.|:::.
Zfish   378 HVFLPGGAELLF-PRQCVGVVTQLQWAEKRPDRKWVWLEEH--DVLLSRQLELRPHGATFEKLVG 439

  Fly   414 CYLLPQQEYQPITPARDLESDSEPFEEREPSRTVV-KFSEEATQEKETPFVRQNTPH---PKDLK 474
            ..:                    |:.:......|| :|..::.....|...|.:..|   |....
Zfish   440 VCI--------------------PYRKTRKGDVVVRRFDGQSWTTLTTMTRRGSDKHSCRPGGRP 484

  Fly   475 AKAQKLKVER---------------SRNEEHANLVTLPEENGTKLAETP---TETRTIANNHQQ- 520
            |:.....|.:               |.:.|.|.||:..:. |.||:..|   .||||:.....|
Zfish   485 ARLACCSVSQFSWFVAVCCPFLDSCSVSPEGALLVSQCDP-GIKLSFPPNCTAETRTVTLQVLQV 548

  Fly   521 ----------QPHPVQQPIVGVNSK------QPVVVGVVTPTTTTVAPTGVQG-----------G 558
                      .||....|::.::..      ||:.|.|       ..|.||.|           .
Zfish   549 ALSEVQDLAGDPHASAGPLLRLSQTPSMHFLQPIRVQV-------PLPPGVTGHMLDLSRLHLMH 606

  Fly   559 SEGASSTANNVKAATAAVVAELAATVGGSDEVQDDDEQEDEF-----------ESDRRVGFQVEG 612
            .:..:.|..:|.|..:..|..:.|..               |           .:.|.|...|.
Zfish   607 GDPTAHTWTDVTAQVSLYVTHIYAVF---------------FITHFSWYWLWYTTHRCVSGVVR- 655

  Fly   613 EDDDFYKRPPKLHRRDTPHHLKNKRVQHLTDKQASEILANALASQERNDTTPQHSLSGKVTSPIE 677
                      |::||     ||..||:.             ||.|.:||  |:..|...:.|
Zfish   656 ----------KMYRR-----LKQFRVRF-------------LALQRKND--PEQILLQCLPS--- 687

  Fly   678 EEEQLEVEQEQQQQQQQHPFDSSLSPISAGKTAEA---------STDPDNLDGVTELRLEQY--- 730
              ::.|...|....|.:.|..|.|..:..|:...|         |..||..||........:
Zfish   688 --DKAESRLESLADQYEGPQPSELCVLLEGEQFFAGFERGIDINSDRPDCKDGRLSFTFYSHLKN 750

  Fly   731 --EIH------IERTAAGLGLSIAGGKGSTPF----------KGDDD 759
              |::      ::.|..|   .::..:|..|.          ||.||
Zfish   751 IKEVYVCATHPVQTTVRG---QVSFYRGEVPSDLPEEVARKRKGHDD 794

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064	74/230 (32%)
		leucine-rich repeat	18..38	CDD:275380
		LRR_8	37..95	CDD:290566	10/23 (43%)
		leucine-rich repeat	39..61	CDD:275380
		leucine-rich repeat	62..84	CDD:275380	3/8 (38%)
		LRR_8	84..138	CDD:290566	12/64 (19%)
		leucine-rich repeat	85..107	CDD:275380	9/32 (28%)
		leucine-rich repeat	108..130	CDD:275380	1/21 (5%)
		LRR_8	129..187	CDD:290566	22/69 (32%)
		leucine-rich repeat	131..153	CDD:275380	5/21 (24%)
		leucine-rich repeat	154..176	CDD:275380	10/33 (30%)
		leucine-rich repeat	177..199	CDD:275380	8/21 (38%)
		LRR_8	198..256	CDD:290566	22/57 (39%)
		leucine-rich repeat	200..222	CDD:275380	11/21 (52%)
		leucine-rich repeat	223..245	CDD:275380	7/21 (33%)
		LRR_8	267..325	CDD:290566	18/57 (32%)
		leucine-rich repeat	269..289	CDD:275380	10/19 (53%)
		leucine-rich repeat	292..314	CDD:275380	4/21 (19%)
		leucine-rich repeat	315..337	CDD:275380	7/23 (30%)
		LRR_4	337..375	CDD:289563	10/50 (20%)
		leucine-rich repeat	361..382	CDD:275380	7/22 (32%)
		PDZ	728..816	CDD:214570	9/53 (17%)
		PDZ_signaling	931..1016	CDD:238492
		PDZ	1239..1329	CDD:214570
		PDZ_signaling	1336..1425	CDD:238492
pidd1	XP_021326274.1	LRR	<148..366	CDD:227223	77/229 (34%)
		leucine-rich repeat	154..188	CDD:275380	10/33 (30%)
		leucine-rich repeat	189..211	CDD:275380	8/21 (38%)
		leucine-rich repeat	212..234	CDD:275380	11/21 (52%)
		leucine-rich repeat	235..258	CDD:275380	7/22 (32%)
		leucine-rich repeat	259..280	CDD:275380	10/20 (50%)
		leucine-rich repeat	281..303	CDD:275380	10/21 (48%)
		leucine-rich repeat	304..326	CDD:275380	4/21 (19%)
		Peptidase_S68	462..501	CDD:313651	6/38 (16%)
		DD	846..932	CDD:326335
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910