DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment scrib and lrrtm4l2

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	XP_009302017.1	Gene:	lrrtm4l2 / 568695	ZFINID:	ZDB-GENE-080327-14	Length:	557	Species:	Danio rerio

Alignment Length:	482	Identity:	118/482 - (24%)
Similarity:	193/482 - (40%)	Gaps:	144/482 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 PIFKGCNRQVEFVDKRHCSLPQVPEEI--------LRYS-------------RTLEELFLDANHI 49
            |:...|..::.:.:..  ....|||.|        |||:             ..|..|:||.|.|
Zfish    31 PVSCRCEGKIVYCESG--GFQDVPENISLGCQGLSLRYNSLLLLLPYQFAHLNQLVWLYLDHNSI 93

  Fly    50 RDLPKNFFR-LHRLRKLGLSDNEIGRLPPDIQN--FE---NLVELDVSRNDIPD-IPDDIKHLQS 107
            ..:.:..|: |.||::|.||.|:|.:|    ||  ||   ||..||:|.|.:.| :|.....|:.
Zfish    94 STVDRLAFQGLRRLKELILSSNKIAQL----QNGTFETVPNLRNLDLSYNQMQDLVPGHFHGLRK 154

  Fly   108 LQVADFSSNPIPKLP--------------SGFSQLKNL---TVLGLNDMSLTTLPAD-------- 147
            ||.....||.|..:|              .|:::|:.:   |.|||  :.||.|..:
Zfish   155 LQNLHLRSNNIRSIPVRTFMECRSLEFLDLGYNRLRTITRTTFLGL--LRLTELHLEHNQFSRIN 217

  Fly   148 ---FGSLTQLESLELRENLLKHLPETISQLT-----KLKRLDLGDNEIEDLPPYL-GYLPGLHEL 203
               |..|..|::|.|:.|.::    |:.|.:     .|::|||..|||:.|.|.: ..||.||.|
Zfish   218 FFLFPRLLNLQALYLQWNRIR----TVVQGSPWTWHTLQKLDLSGNEIQILDPAIFRCLPNLHTL 278

  Fly   204 WLDHNQLQRLPPELGLLTKLTYLDVSENRLEELPNEISGLVSLTDLDLAQNLLEALPDGIAKLSR 268
            .|:.|::..:..|:                      :|..:|::.::||.|:.:........:|.
Zfish   279 NLESNKISNVSLEV----------------------VSSWISISTINLAGNIWDCSSSICPLVSW 321

  Fly   269 L---------TILKLDQNRLQ--RLNDTLGN---CENM------QELIL------TENFLSELPA 307
            |         :|:......||  |:.|.:.|   ||.|      .||.|      |..::::.|.
Zfish   322 LRNFRGTRDASIICSTPKSLQGERVMDAVRNNSVCEEMFTVEPTTELTLLLTTTTTTLYVTKPPT 386

  Fly   308 S-----------IGQMTKLNNLNVDRNALEYLPLEIGQCANLGVLSLRDNKLKKLP-PELGNCTV 360
            :           :.|:|.:..|    .....||:.    .....|::..:.|...| ||..:.|
Zfish   387 TTTTTPRTTTRQLSQVTHIQRL----TPKVLLPVR----PEKEFLTVTPSSLPFTPEPEFEHMT- 442

  Fly   361 LHVLDVSGNQLLYLPYSLVNLQLKAVW 387
            .|.: ::|:..|:|..||:.|.:...|
Zfish   443 FHKI-IAGSVALFLSVSLILLVIYVSW 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064	87/342 (25%)
		leucine-rich repeat	18..38	CDD:275380	7/40 (18%)
		LRR_8	37..95	CDD:290566	26/63 (41%)
		leucine-rich repeat	39..61	CDD:275380	8/22 (36%)
		leucine-rich repeat	62..84	CDD:275380	11/26 (42%)
		LRR_8	84..138	CDD:290566	21/71 (30%)
		leucine-rich repeat	85..107	CDD:275380	8/22 (36%)
		leucine-rich repeat	108..130	CDD:275380	8/35 (23%)
		LRR_8	129..187	CDD:290566	20/76 (26%)
		leucine-rich repeat	131..153	CDD:275380	9/35 (26%)
		leucine-rich repeat	154..176	CDD:275380	6/26 (23%)
		leucine-rich repeat	177..199	CDD:275380	10/22 (45%)
		LRR_8	198..256	CDD:290566	12/57 (21%)
		leucine-rich repeat	200..222	CDD:275380	6/21 (29%)
		leucine-rich repeat	223..245	CDD:275380	1/21 (5%)
		LRR_8	267..325	CDD:290566	19/94 (20%)
		leucine-rich repeat	269..289	CDD:275380	7/33 (21%)
		leucine-rich repeat	292..314	CDD:275380	7/44 (16%)
		leucine-rich repeat	315..337	CDD:275380	3/21 (14%)
		LRR_4	337..375	CDD:289563	9/38 (24%)
		leucine-rich repeat	361..382	CDD:275380	6/20 (30%)
		PDZ	728..816	CDD:214570
		PDZ_signaling	931..1016	CDD:238492
		PDZ	1239..1329	CDD:214570
		PDZ_signaling	1336..1425	CDD:238492
lrrtm4l2	XP_009302017.1	LRR_8	<74..117	CDD:290566	14/42 (33%)
		leucine-rich repeat	83..106	CDD:275380	8/22 (36%)
		LRR_8	105..165	CDD:290566	25/63 (40%)
		LRR_RI	107..307	CDD:238064	64/231 (28%)
		leucine-rich repeat	107..130	CDD:275380	11/26 (42%)
		leucine-rich repeat	131..154	CDD:275380	8/22 (36%)
		LRR_8	153..213	CDD:290566	15/61 (25%)
		leucine-rich repeat	155..178	CDD:275380	6/22 (27%)
		leucine-rich repeat	179..202	CDD:275380	6/24 (25%)
		leucine-rich repeat	203..226	CDD:275380	5/22 (23%)
		LRR_8	226..285	CDD:290566	22/62 (35%)
		leucine-rich repeat	227..250	CDD:275380	6/26 (23%)
		leucine-rich repeat	251..274	CDD:275380	10/22 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910