DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment scrib and AgaP_AGAP008171

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	XP_001689016.1	Gene:	AgaP_AGAP008171 / 5668341	VectorBaseID:	AGAP008171	Length:	680	Species:	Anopheles gambiae

Alignment Length:	495	Identity:	118/495 - (23%)
Similarity:	198/495 - (40%)	Gaps:	144/495 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 IPIFKGCNRQVEFVDKRHCSLPQVPEEILRYSRTLEELFL-------DANHIR-DLPKNFFRLHR 61
            :|:..|.:..    |.|..:||          :.||:.||       |.|.:: |:...|.||..
Mosquito   195 VPMLYGMDAN----DNRLRALP----------KCLEQAFLNVVRLAFDRNQLQPDVMFQFGRLTS 245

  Fly    62 LRKLGLSDNEIGRLPPDIQNF-ENLVELDVSRN-----DIPDIPDDIKHLQSLQVADFSSNPIPK 120
            |:.|.|:||::..:..::... :.|..|::|.|     |:|..|....|:      |.|||.|..
Mosquito   246 LKFLTLTDNKLPYVTLNMSTIPKQLRHLNLSHNKLKHLDVPYAPSKDFHI------DVSSNCISS 304

  Fly   121 LPSGFSQLK-NLTVLGLND--------------------------MSLTTLPADFGSLTQLESLE 158
            :  .:.::. |||.||:.:                          :::|.|.:|.....:|.:.|
Mosquito   305 V--DWDRVSANLTKLGMGENPLDCSFHSISTRADIRSKLHIHFRYLNVTKLHSDLLDRVKLSNDE 367

  Fly   159 LRENLLKHLP------ETISQLTKLKRLD--LGDNEIEDLPPYLGYLPGLHELWLDHNQLQRLPP 215
            ..:..::|.|      .:.:.:|.|..||  |.|.|||.      :.|.|..|.:..::|:.:|.
Mosquito   368 TLQATIQHSPIQQAYLSSRTNITSLLLLDTNLSDIEIEP------HNPKLEILTIMKSRLRCVPD 426

  Fly   216 ELGLL--------TKLTYLDVSENRLEELP-----------------NEISGLVSLTDLDLAQNL 255
            .:..|        .|:::|:.|.:...|.|                 |:.:|:..|..|||:.|.
Mosquito   427 SIKQLAVVLNLMQNKISFLNYSCSSGVEFPSLRVIYLAHNLLTTIGMNDFNGMKLLNILDLSNNS 491

  Fly   256 LEALPDGIAKLSRLTILKLDQNRLQRLNDTLGNCENMQELILTENFLSELPASIGQMTKLNNLNV 320
            |.:| :|..:||.||.||                       |:.|..:||......::.|.||::
Mosquito   492 LHSL-EGQLRLSSLTDLK-----------------------LSHNHFTELSCCGWNLSSLTNLDI 532

  Fly   321 DRNALEYLP------LEIGQCANL--GVLSLRDNKLKKLPPELGNCTVLHVLDVSGNQLLYLPYS 377
            :.|.|:.||      |.|....||  .|||..||    :...|.:.:.|.:||:|.|:|..:.:.
Mosquito   533 NNNTLQRLPTCMEDALPIVSYLNLVSNVLSNDDN----IWDRLASLSQLTLLDLSYNRLTSMVWD 593

  Fly   378 LVNLQLKAVWLSENQSQ----PLLT--FQPDTDAETGEQV 411
            .|.|..:.:.|..|..:    |:..  |..|....|.:|:
Mosquito   594 NVTLSTRYINLRNNPMKYLNIPMAIDGFNVDMGCTTFDQL 633

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064	80/343 (23%)
		leucine-rich repeat	18..38	CDD:275380	4/19 (21%)
		LRR_8	37..95	CDD:290566	19/71 (27%)
		leucine-rich repeat	39..61	CDD:275380	10/29 (34%)
		leucine-rich repeat	62..84	CDD:275380	5/22 (23%)
		LRR_8	84..138	CDD:290566	18/59 (31%)
		leucine-rich repeat	85..107	CDD:275380	8/26 (31%)
		leucine-rich repeat	108..130	CDD:275380	5/22 (23%)
		LRR_8	129..187	CDD:290566	18/92 (20%)
		leucine-rich repeat	131..153	CDD:275380	7/47 (15%)
		leucine-rich repeat	154..176	CDD:275380	4/27 (15%)
		leucine-rich repeat	177..199	CDD:275380	8/23 (35%)
		LRR_8	198..256	CDD:290566	18/82 (22%)
		leucine-rich repeat	200..222	CDD:275380	5/29 (17%)
		leucine-rich repeat	223..245	CDD:275380	6/38 (16%)
		LRR_8	267..325	CDD:290566	13/57 (23%)
		leucine-rich repeat	269..289	CDD:275380	4/19 (21%)
		leucine-rich repeat	292..314	CDD:275380	4/21 (19%)
		leucine-rich repeat	315..337	CDD:275380	9/27 (33%)
		LRR_4	337..375	CDD:289563	14/39 (36%)
		leucine-rich repeat	361..382	CDD:275380	7/20 (35%)
		PDZ	728..816	CDD:214570
		PDZ_signaling	931..1016	CDD:238492
		PDZ	1239..1329	CDD:214570
		PDZ_signaling	1336..1425	CDD:238492
AgaP_AGAP008171	XP_001689016.1	leucine-rich repeat	103..128	CDD:275380
		LRR_8	127..185	CDD:290566
		leucine-rich repeat	129..152	CDD:275380
		leucine-rich repeat	153..174	CDD:275380
		leucine-rich repeat	175..197	CDD:275380	0/1 (0%)
		leucine-rich repeat	198..224	CDD:275380	9/39 (23%)
		leucine-rich repeat	225..245	CDD:275380	6/19 (32%)
		leucine-rich repeat	246..269	CDD:275380	5/22 (23%)
		leucine-rich repeat	270..294	CDD:275380	7/23 (30%)
		leucine-rich repeat	411..430	CDD:275380	4/18 (22%)
		leucine-rich repeat	434..457	CDD:275378	4/22 (18%)
		LRR_RI	<456..588	CDD:238064	43/159 (27%)
		LRR_8	456..514	CDD:290566	19/81 (23%)
		leucine-rich repeat	458..481	CDD:275380	2/22 (9%)
		LRR	<482..>614	CDD:227223	45/159 (28%)
		leucine-rich repeat	482..503	CDD:275380	9/21 (43%)
		leucine-rich repeat	504..526	CDD:275380	8/44 (18%)
		leucine-rich repeat	527..550	CDD:275380	8/22 (36%)
		leucine-rich repeat	551..576	CDD:275380	8/28 (29%)
		leucine-rich repeat	577..599	CDD:275380	8/21 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910