DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment scrib and AgaP_AGAP007468

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	XP_001687916.1	Gene:	AgaP_AGAP007468 / 5666871	VectorBaseID:	AGAP007468	Length:	406	Species:	Anopheles gambiae

Alignment Length:	348	Identity:	85/348 - (24%)
Similarity:	146/348 - (41%)	Gaps:	57/348 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 QVPEEILRYSRTLEEL-FLDANHIRDLPKNFFRLHRLRKLGLSDNEIGRLPPDIQNFENLVE--- 87
            |:|.:     .||.|: .::...:|.|.....|  .|.:|.:.:..:.|:||.:.|...|.|
Mosquito    61 QLPAD-----NTLTEIEIVNGVMLRSLVAGTNR--HLTRLYVENCLLDRIPPTLSNMIELEELLI 118

  Fly    88 ---------LDVSRNDIPDIPDDIKHLQSLQVADFSSNPIPKLPSGF-----SQLKNLTVLGLND 138
                     |||..|:......|:...:..|:...::.|..||...|     :||:.|      |
Mosquito   119 MQCALTALRLDVLVNNPKLTTIDLTRNRIRQLFPITTPPKTKLAVTFLGLAANQLERL------D 177

  Fly   139 MSLTTLPADFGSLTQLESLELRENLLKHL----PETISQLTKLKRLDLGDNEIEDLPPYLGYLPG 199
            ||:      |..:.:||..::|.|.:...    |.|...||   ||.:..|.|.........|..
Mosquito   178 MSM------FAFMPELEQFDVRGNRIVRFEATAPVTYGSLT---RLLVSSNNITQFDTRNLTLSE 233

  Fly   200 LHELWLDHNQLQRLPPELGLLTKLTYLDVSENRLEELPNEISG-LVSLTDLDLAQNLLEALPDGI 263
            |..|:||.|.|..||...|.|.||.||....|.|:.:.....| ..:||.:.:::|::|.:....
Mosquito   234 LRSLYLDDNALTELPTHWGKLPKLIYLGFDRNYLKRVDMSFFGKFPTLTAIFISENIVETIRTST 298

  Fly   264 -AKLSRLTILKLDQNRLQRLNDTLGNCENMQELILTENFLSELPASIGQMTKLNNLNVDRNALEY 327
             ..:..|.|:..:.|::..:|.|..|...|..:.||.|.|:.:|..:.:.:: :.|.::.|.:
Mosquito   299 PITMPELDIILFESNQIVSVNFTGCNFPKMNLVSLTNNRLTTIPPLLQRFSE-SRLTMEGNPI-- 360

  Fly   328 LPLEIGQCANLGVL--SLRDNKL 348
                  :|:::..|  .:.|.:|
Mosquito   361 ------KCSSMTALKSKITDYRL 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064	70/279 (25%)
		leucine-rich repeat	18..38	CDD:275380	2/10 (20%)
		LRR_8	37..95	CDD:290566	18/70 (26%)
		leucine-rich repeat	39..61	CDD:275380	5/22 (23%)
		leucine-rich repeat	62..84	CDD:275380	6/21 (29%)
		LRR_8	84..138	CDD:290566	15/70 (21%)
		leucine-rich repeat	85..107	CDD:275380	7/33 (21%)
		leucine-rich repeat	108..130	CDD:275380	7/26 (27%)
		LRR_8	129..187	CDD:290566	16/61 (26%)
		leucine-rich repeat	131..153	CDD:275380	5/21 (24%)
		leucine-rich repeat	154..176	CDD:275380	7/25 (28%)
		leucine-rich repeat	177..199	CDD:275380	5/21 (24%)
		LRR_8	198..256	CDD:290566	20/58 (34%)
		leucine-rich repeat	200..222	CDD:275380	10/21 (48%)
		leucine-rich repeat	223..245	CDD:275380	6/22 (27%)
		LRR_8	267..325	CDD:290566	14/57 (25%)
		leucine-rich repeat	269..289	CDD:275380	5/19 (26%)
		leucine-rich repeat	292..314	CDD:275380	6/21 (29%)
		leucine-rich repeat	315..337	CDD:275380	3/21 (14%)
		LRR_4	337..375	CDD:289563	3/14 (21%)
		leucine-rich repeat	361..382	CDD:275380
		PDZ	728..816	CDD:214570
		PDZ_signaling	931..1016	CDD:238492
		PDZ	1239..1329	CDD:214570
		PDZ_signaling	1336..1425	CDD:238492
AgaP_AGAP007468	XP_001687916.1	LRR_8	88..147	CDD:290566	14/60 (23%)
		leucine-rich repeat	90..112	CDD:275380	6/21 (29%)
		leucine-rich repeat	113..136	CDD:275380	6/22 (27%)
		LRR_8	135..197	CDD:290566	17/73 (23%)
		leucine-rich repeat	137..160	CDD:275380	3/22 (14%)
		leucine-rich repeat	161..186	CDD:275380	9/36 (25%)
		LRR_8	185..244	CDD:290566	18/61 (30%)
		leucine-rich repeat	187..210	CDD:275380	6/22 (27%)
		leucine-rich repeat	211..233	CDD:275380	7/24 (29%)
		LRR_8	232..289	CDD:290566	19/56 (34%)
		leucine-rich repeat	234..256	CDD:275380	10/21 (48%)
		leucine-rich repeat	257..280	CDD:275380	6/22 (27%)
		leucine-rich repeat	281..304	CDD:275380	4/22 (18%)
		leucine-rich repeat	305..327	CDD:275380	6/21 (29%)
		leucine-rich repeat	328..351	CDD:275380	6/23 (26%)
		leucine-rich repeat	352..370	CDD:275380	4/25 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910