DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment scrib and AgaP_AGAP000055

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	XP_001687755.2	Gene:	AgaP_AGAP000055 / 5666802	VectorBaseID:	AGAP000055	Length:	676	Species:	Anopheles gambiae

Alignment Length:	821	Identity:	201/821 - (24%)
Similarity:	279/821 - (33%)	Gaps:	342/821 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly  1932 EPDSPSAAGG-------------SRIPVRTLKAERRALTLAARQSGLSVEEYLKRLETQDDKESP 1983
            |.:....|||             ||||:||:.||:|     ||.|.....||         .||.
Mosquito    30 EDEQGRVAGGLLTAASPLAKTPMSRIPIRTVNAEKR-----ARASNCLPPEY---------DESK 80

  Fly  1984 ASPTTPTGKSRSMINAEKRASWRAARLRSLEQGAVEAQDVIKNMRK---MTDDLITHESRASE-V 2044
            .||:    :.|: :.|:|||:||.|||:|||..|::||.:|:.|..   :.:|.:.:.|.||| |
Mosquito    81 LSPS----EIRA-LRAQKRAAWRQARLKSLENDALQAQIMIQTMAAGLGLHEDSLLNSSSASEGV 140

  Fly  2045 ETCKERIISLELQVPETEDEGKLDDTQPPLEL----EADDFQDDE-----DDDDDDDDEDDFEDE 2100
            :.      |.........:...|...|.||..    .||:..:.|     ||||||||..|....
Mosquito   141 DG------SFSRSALAASNVSPLPAAQSPLPTPPAPSADNNDEHEPSANGDDDDDDDDHHDGRSS 199

  Fly  2101 DEEE----------------------------DTASIV--------------------------- 2110
            ..:|                            :|..:|
Mosquito   200 SADEAGGADDRLQRRFPRLAVKSRPGSEIVVRETEKVVEEKVTRRTEEAPGGGLRTVEYIEKVIE 264

  Fly  2111 -TVQANNEKLFLRHDSDTYGPSSIESVASGKVRIK---PTPL-------------SLHQ--TLAK 2156
             .|:...||:.:....|:....| |....|||..|   ||..             ::||  ...:
Mosquito   265 TEVETMREKIIMFELEDSSSADS-ERDGGGKVEAKNGMPTDQADGTDRWLDGSEPAVHQPDQPVQ 328

  Fly  2157 ETTIVEVLNPVIGGDGSARTI------HVSGGLPFDEDAFEQGAVAVLRSETFVLPGAAGG---- 2211
            ..|||||:||::.|||....|      .|:.|   :||:.....|....:.....|....|
Mosquito   329 LQTIVEVINPMLSGDGQPNDIAIGRYSDVAYG---EEDSLVVDGVEDATATDATTPVEYAGRYAY 390

  Fly  2212 --GRSELSLNAKMKTVLEELLENERVKLNLQKSLEGEE------------GEDDDDEDENGSAYG 2262
              |..| |:|.|||.||.||.:||:|:.||.|||..||            .||..:|:|......
Mosquito   391 EHGAYE-SINDKMKHVLRELKQNEKVRQNLSKSLTEEEILALQAQELAEQEEDGLEEEEEEEEEE 454

  Fly  2263 DARDEEESAYGDAIDDVVDFGSATVTSRAAND--------------KDDVKNGNQQLLE------ 2307
            |.|::.|...| ||..|.     .|..|..||              :...|...|:|::
Mosquito   455 DVREQYEEKTG-AIGTVF-----MVRERLINDFYTHQTELAHEQQQQQQRKYHQQKLMDDPASYR 513

  Fly  2308 --ELIKDSNRNTIIAKL------AGQL---------------SDDDEEDDDEEESSDSSDDDSDD 2349
              |:|.:.:.:......      ||||               |||.:|||||:          ||
Mosquito   514 DCEVITNPSADRFSPTFDHHSGPAGQLYHQTIHSEKLRAVFGSDDGDEDDDED----------DD 568

  Fly  2350 SDEEDNAQQQLNVTYVQGAQVIENLNTLATGGKLQKSQTYTAIKQAEEPKEEDTKLEEDPSAEKP 2414
            ..||:.|:.:            .|.||:  ||.:..:.........||.:||:...|||
Mosquito   569 ECEEERAEDR------------RNGNTI--GGVVAPATEPATAAGVEEQEEEEEDEEED------ 613

  Fly  2415 CGADTLAKLQAEQRALAEISKQLRKSVEDLLSADGETVVETQRTYTLPAPSDSSAVVTVTEVVKK 2479
               |.:.   |..||:|..:     :||   .::|.:             |::|:..|.|
Mosquito   614 ---DVII---APSRAVAATA-----AVE---PSNGTS-------------SNASSATTAT----- 646

  Fly  2480 QKKKKSETGEELFNRLLNAAESERQVFDRQQGETITTTTTTTEAVSSEDNEPSTSVVTTTRTVSN 2544
                                             |.||||||..||.|
Mosquito   647 ---------------------------------TTTTTTTTATAVPS------------------ 660

  Fly  2545 IVTSGIPRPETSKQNNRSSSSSNSNSSNNNRNKNKRKGKKK 2585
                                     |:.||:.| |||||||
Mosquito   661 -------------------------STGNNKRK-KRKGKKK 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064
		leucine-rich repeat	18..38	CDD:275380
		LRR_8	37..95	CDD:290566
		leucine-rich repeat	39..61	CDD:275380
		leucine-rich repeat	62..84	CDD:275380
		LRR_8	84..138	CDD:290566
		leucine-rich repeat	85..107	CDD:275380
		leucine-rich repeat	108..130	CDD:275380
		LRR_8	129..187	CDD:290566
		leucine-rich repeat	131..153	CDD:275380
		leucine-rich repeat	154..176	CDD:275380
		leucine-rich repeat	177..199	CDD:275380
		LRR_8	198..256	CDD:290566
		leucine-rich repeat	200..222	CDD:275380
		leucine-rich repeat	223..245	CDD:275380
		LRR_8	267..325	CDD:290566
		leucine-rich repeat	269..289	CDD:275380
		leucine-rich repeat	292..314	CDD:275380
		leucine-rich repeat	315..337	CDD:275380
		LRR_4	337..375	CDD:289563
		leucine-rich repeat	361..382	CDD:275380
		PDZ	728..816	CDD:214570
		PDZ_signaling	931..1016	CDD:238492
		PDZ	1239..1329	CDD:214570
		PDZ_signaling	1336..1425	CDD:238492
AgaP_AGAP000055	XP_001687755.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BA7S
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005473
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.900