DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scrib and lrrc7

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	XP_005166019.1	Gene:	lrrc7 / 566023	ZFINID:	ZDB-GENE-130530-876	Length:	1556	Species:	Danio rerio

Alignment Length:	1716	Identity:	451/1716 - (26%)
Similarity:	688/1716 - (40%)	Gaps:	490/1716 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 FKGCNRQVEFVDKRHCSLPQVPEEILRYSRTLEELFLDANHIRDLPKNFFRLHRLRKLGLSDNEI 72
            |:|....:..:|..||||.|||:||..:.||||||:||||.|.:|||..|....|:||.:.||::
Zfish    30 FRGEEEVISVLDYSHCSLQQVPKEIFSFERTLEELYLDANQIEELPKQLFNCQALKKLSMPDNDL 94

  Fly    73 GRLPPDIQNFENLVELDVSRNDIPDIPDDIKHLQSLQVADFSSNPIPKLPSGFSQLKNLTVLGLN 137
            ..||..|.:..||.|||:|:|.|.:.||:||..:.|.|.:.|.|||.|||.||:||.|||.|.||
Zfish    95 SNLPTTIASLVNLKELDISKNGIQEFPDNIKCCKCLSVVEASVNPIAKLPEGFTQLLNLTQLFLN 159

  Fly   138 DMSLTTLPADFGSLTQLESLELRENLLKHLPETISQLTKLKRLDLGDNEIEDLPPYLGYLPGLHE 202
            |..|..|||:||.|::|..||||||.||.:|::|.:|::|:|||||.||..:||..|..:..|.|
Zfish   160 DAFLEYLPANFGRLSKLRILELRENHLKTMPKSIHRLSQLERLDLGSNEFSELPEVLEQIHSLKE 224

  Fly   203 LWLDHNQLQRLPPELGLLTKLTYLDVSENRLEELPNEISGLVSLTDLDLAQNLLEALPDGIAKLS 267
            ||||:|.||.:|..:|.|.:|.|||:::||:|.|..:|||..||.||.|:.|:|:.|||.|.||.
Zfish   225 LWLDNNSLQTIPGSIGKLRQLRYLDLAKNRIESLDADISGCESLEDLLLSANMLQQLPDSIGKLK 289

  Fly   268 RLTILKLDQNRLQRLNDTLGNCENMQELILTENF------LSELPASIGQMTKLNNLNVDRNALE 326
            :||.||:|.|:|..|.:|:|:......|.|.|.|      |..||.:||.:..|.....|.|.|.
Zfish   290 KLTTLKVDDNQLTSLPNTIGSAHGKFGLSLLEEFDCSCNELESLPPTIGYLHSLRTFAADENFLS 354

  Fly   327 YLPLEIGQCANLGVLSLRDNKLKKLPPELGNCTVLHVLDVSGNQLLYLPYSLVNLQ-LKAVWLSE 390
            .||.|||.|.|:.|:|||.|||:.||.|:|..|.|.||::|.|:|..||::...|: |.|:|||:
Zfish   355 DLPREIGNCRNVTVMSLRSNKLEFLPDEIGQMTKLRVLNLSDNRLKNLPFTFTKLKDLAALWLSD 419

  Fly   391 NQSQPLLTFQPDTDAETGEQVLSCYLLPQQEYQPITPARDLESDSEPF-----EEREPSRTVVKF 450
            |||:.|:..|.:...||.::||:.|:.|||....    .|.:||::.|     ||:...|..|.|
Zfish   420 NQSKALIPLQTEAHPETKQRVLTNYMFPQQPRHD----EDYQSDTDSFNPTLWEEQRQQRMTVAF 480

  Fly   451 SEEATQEK---------ETPFVRQNTPHPKDLKAKAQKLKVERSRNEEHANLVTLPEENGTKLAE 506
            ..|..:|:         |....|..||:|:|||...:.::          |||      |.....
Zfish   481 EFEDKKEEEDNSGKVKVEINLKRYPTPYPEDLKNMVKSVQ----------NLV------GKTTHP 529

  Fly   507 TPTETRTIANN---HQQQPHPVQQPI---------VGVNSKQPVV-VGVVTPTTTTVAPTGVQGG 558
            ..||..:...|   |.|..:..:.||         |...|.||:. .||:..:...: |...:..
Zfish   530 LNTEKCSSGTNMELHSQDKYEPKWPIAPKEVTERDVKDYSNQPMSDQGVILNSAIDI-PKRKEDL 593

  Fly   559 SEGASSTANNV-------KAATAAVVAE----LAATVGGS-DEVQDDD----------------- 594
            :|.:..:.:.|       :..:.||.:.    |..::||| ::::..|
Zfish   594 TESSEISLHRVVPKPQQPENTSLAVSSSSCFCLIDSMGGSPNDIRISDMRPTLVEPPMYKPKVVL 658

  Fly   595 ------EQEDEFESDR------------------------------RVG-FQVEGEDD------- 615
                  |..||.|.|:                              .|| .|..|::.
Zfish   659 LGKEKKESTDESEPDKMHCLNNSGSSATYSDYSPSQGSSGSSNPPGNVGNLQTSGKEGSSQTHWT 723

  Fly   616 ----DFYKRP----PKLHRRDTPHHLKNKRVQHLTDKQASEILANALASQERNDTTPQHSLSGKV 672
                ..:.:|    |.|.:|:||   .:..:|...:::.   |::...|.  || .|.:..:|.|
Zfish   724 NRLAQSFPKPIETKPLLSQRETP---PSSTLQQRGERRP---LSDTFDSW--ND-APHYDNTGFV 779

  Fly   673 TSPIEEEEQLEVEQEQQQQQQQHPFDSSLSPISAGKTAEAST--------DPDNLDGV-TELRLE 728
            .    ||..|:.           |..|:.:|:...|...|||        ..|.:.|| .||...
Zfish   780 A----EEMPLDT-----------PSSSAGNPMLGSKPRSASTAHGRRPLMRQDRIVGVPLELDQT 829

  Fly   729 QYEIHI---------------------------ERTAAGLGLSIAGGKGSTPFK-------GDDD 759
            |...|.                           :|||....|.|.......|.:       |:..
Zfish   830 QQTFHTVRNTPDTEVPAPSNPWQNWTRTPSPFEDRTAFPSKLEITPANSPNPDRKDFEQEMGEIP 894

  Fly   760 GIFISR-------VTEAG-----PADLAGLKVGDKVIKVNGIVV--------------------- 791
            |.|.|.       .|::|     |.....::||.:..|.|.:|:
Zfish   895 GTFPSTGAWGFLDSTDSGTGRGHPNVYTHIQVGKEPNKGNTMVLSKSSERLSPMMKEVKAKFKKS 959

  Fly   792 -----VDADHYQAVQV--------LKACGAV----LVLVVQREVTRLIGHPVFSED---GSVSQI 836
                 :|...|:...:        ::..|:|    ..:.:::.::|....|:..:|   ..:::.
Zfish   960 QSIDEIDTGSYKVYSIPMDSYSSSIENQGSVDRADFPIPLEQSMSRSQSAPMLDDDLDGYGLNKS 1024

  Fly   837 SVETRPLVADA---------PPAAS--ISHERYIPAPIEIVPQQQHLQQQQQQPIQQVAPTHSYS 890
            |.:.:|.:...         |..|.  :..||.:|.|....|:..: |..:..|.:.|:| ..|.
Zfish  1025 SQQQKPAIPKKVYHFDQSFNPQGAMDVLKAERRVPPPFPNTPEYVN-QPGKTLPKELVSP-RGYR 1087

  Fly   891 GNVFATPTAAQTVQPAVSAAPNGLLLNGREAPLSYIQLHTTLIRDQIGQGLGFSIAGGKGSPPFK 955
            |        ...::...|.|||.                   ..|...|.|  |:...:..|.|.
Zfish  1088 G--------YPQMEQVFSFAPNA-------------------TDDSHNQQL--SVQPQRSRPGFL 1123

  Fly   956 DDCDGIFISRITEGGLAYRDGKIMVGDRVMAINGNDMTEAHHDAAVACLTEPQRFVRLVLQR--- 1017
            ...|.:..|  ||..|..|           ....:::..|.|      .:.||:...::.|:
Zfish  1124 RRADSLVSS--TEMALFRR-----------VAENHELQLAEH------YSRPQQIKSMLEQQNSL 1169

  Fly  1018 --------------------EYRGPLEP----PT---SPRSPAVLNSLSPSGYLAN--RPANFSR 1053
                                .|:.|.:|    ||   :.|.|....|.|...|.|:  ||.:...
Zfish  1170 STMADTQFHKRNGRYDEDYSSYQEPKKPIMGYPTKSLTQRRPLSARSYSTETYGASQARPVSARP 1234

  Fly  1054 SVVEV--EQPYKYNTLATTTPTPKPTVPASISNNNNTLPSSKTNGFATAAAATIDSSTGQPV--- 1113
            ::..:  :.|..||....|..:|:..:      |...:|..:.           |.::..||
Zfish  1235 TMAALLEKLPSDYNLSTCTEKSPEADM------NLRPVPQKQE-----------DLTSKMPVDWR 1282

  Fly  1114 -------PAPRRTNSVPMGDGDIGAGSTTSGDSGEAQPSSLRPLTSDDFQAMIPAHFLSGGSQHQ 1171
                   .|.|...|..:....:..|...||  |.|.|.:.|.:|.:.:          ..::|:
Zfish  1283 QQLLRHIEAKRLDRSAVLKHNTVNFGMLYSG--GYAAPHASRSMTINFY----------NNTKHE 1335

  Fly  1172 VHVARPNEVGVSAVTVNVNKPQPDLPMFPAAPTELGRVTETITKSTFTETVMTRITDNQLAEPLI 1236
                              |:....||: |..|::                 .:.|.||
Zfish  1336 ------------------NQTTQWLPL-PNTPSQ-----------------QSNILDN------- 1357

  Fly  1237 SEEVVLPKNQG---SLGFSIIGGTDHSCVPFGTREPGIFISHIVPGGIASKCGKLRMGDRILKVN 1298
            .:||:.|.:|.   |||...:...:.:.:    ::||:...|               ..:.:.:.
Zfish  1358 GQEVMSPSSQWAPYSLGRRDVPPENMNII----KKPGVHNPH---------------QQQTMMIT 1403

  Fly  1299 EADVSKATHQDAVLELLKPGDEIKLTIQ--HDPLP-------------------------PGFQE 1336
            .|.....|.:|...|    |...|::||  ..|||                         .||.|
Zfish  1404 SAPPPHRTARDQQYE----GAINKVSIQQYQSPLPMPITTTSPRPQSARCFIQTKGQKSMDGFPE 1464

  Fly  1337 VLLSKAE-GERLGMHIKGGLNGQRGNPADPSDEGVFVSKINSVGAARRDGRLKVGMRLLEVNGHS 1400
            .|..:.| ...||..|.||::|| |||..|||.|:||:::...|.|  ...|:.|.::|:.||||
Zfish  1465 QLCVRIEKNPGLGFSISGGISGQ-GNPFKPSDMGIFVTRVQPDGPA--SNVLRPGDKILKANGHS 1526

  Fly  1401 LLGASHQDAVNVLRNAGNEIQLVVCK 1426
            .|...|:.||::|:|....:.||:.:
Zfish  1527 FLHMEHETAVSLLKNFPKTVDLVILR 1552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064	138/269 (51%)
		leucine-rich repeat	18..38	CDD:275380	10/19 (53%)
		LRR_8	37..95	CDD:290566	30/57 (53%)
		leucine-rich repeat	39..61	CDD:275380	13/21 (62%)
		leucine-rich repeat	62..84	CDD:275380	8/21 (38%)
		LRR_8	84..138	CDD:290566	30/53 (57%)
		leucine-rich repeat	85..107	CDD:275380	11/21 (52%)
		leucine-rich repeat	108..130	CDD:275380	13/21 (62%)
		LRR_8	129..187	CDD:290566	33/57 (58%)
		leucine-rich repeat	131..153	CDD:275380	13/21 (62%)
		leucine-rich repeat	154..176	CDD:275380	12/21 (57%)
		leucine-rich repeat	177..199	CDD:275380	11/21 (52%)
		LRR_8	198..256	CDD:290566	29/57 (51%)
		leucine-rich repeat	200..222	CDD:275380	12/21 (57%)
		leucine-rich repeat	223..245	CDD:275380	11/21 (52%)
		LRR_8	267..325	CDD:290566	22/63 (35%)
		leucine-rich repeat	269..289	CDD:275380	10/19 (53%)
		leucine-rich repeat	292..314	CDD:275380	9/27 (33%)
		leucine-rich repeat	315..337	CDD:275380	10/21 (48%)
		LRR_4	337..375	CDD:289563	19/37 (51%)
		leucine-rich repeat	361..382	CDD:275380	8/20 (40%)
		PDZ	728..816	CDD:214570	24/171 (14%)
		PDZ_signaling	931..1016	CDD:238492	16/84 (19%)
		PDZ	1239..1329	CDD:214570	18/94 (19%)
		PDZ_signaling	1336..1425	CDD:238492	36/89 (40%)
lrrc7	XP_005166019.1	LRR_RI	<37..269	CDD:238064	119/231 (52%)
		leucine-rich repeat	39..60	CDD:275380	10/20 (50%)
		LRR_8	59..117	CDD:290566	30/57 (53%)
		leucine-rich repeat	61..83	CDD:275380	13/21 (62%)
		leucine-rich repeat	84..106	CDD:275380	8/21 (38%)
		leucine-rich repeat	107..152	CDD:275380	24/44 (55%)
		leucine-rich repeat	153..175	CDD:275380	13/21 (62%)
		LRR_8	174..232	CDD:290566	30/57 (53%)
		leucine-rich repeat	176..198	CDD:275380	12/21 (57%)
		leucine-rich repeat	199..221	CDD:275380	11/21 (52%)
		LRR_8	221..278	CDD:290566	29/56 (52%)
		leucine-rich repeat	222..244	CDD:275380	12/21 (57%)
		leucine-rich repeat	245..267	CDD:275380	11/21 (52%)
		LRR_4	266..306	CDD:289563	21/39 (54%)
		leucine-rich repeat	291..319	CDD:275380	11/27 (41%)
		leucine-rich repeat	343..365	CDD:275380	10/21 (48%)
		LRR_8	364..421	CDD:290566	27/56 (48%)
		LRR_4	365..403	CDD:289563	19/37 (51%)
		leucine-rich repeat	366..388	CDD:275380	11/21 (52%)
		LRR_4	387..429	CDD:289563	19/41 (46%)
		leucine-rich repeat	389..411	CDD:275380	9/21 (43%)
		PDZ_signaling	1468..1551	CDD:238492	34/85 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BA7S
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D148064at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820