DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scrib and apba1b

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	XP_005155643.1	Gene:	apba1b / 565507	ZFINID:	ZDB-GENE-070925-3	Length:	971	Species:	Danio rerio

Alignment Length:	1126	Identity:	214/1126 - (19%)
Similarity:	376/1126 - (33%)	Gaps:	403/1126 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   390 ENQSQPLLTFQPDTDAETGEQVLSCYLLPQQEYQPIT-----PARDLESDSEPFEEREPSRTVVK 449
            |..|:|||:  ||..::.       .|.|..:.:|:|     .:.||...|:....|:|.:
Zfish   136 EQASEPLLS--PDDSSQD-------LLTPSPQDEPVTDELDESSPDLSHSSDTQINRDPEQ---- 187

  Fly   450 FSEEATQEKETPFVRQNTPHPKDLK--AKAQKLKVERSRNEEHANLVTLPEEN--GTKLA--ETP 508
              |:|....:.|   :...|.::.|  .:.:.:||    ||.......:|||:  ..|:|  ..|
Zfish   188 --EQAESSVDQP---EENVHREEFKNPCEEELVKV----NEVEDLSTQIPEEDYVPPKIASKSRP 243

  Fly   509 TETRT----------IANNHQ-------QQPHPVQQPIVGVNSKQPVVVGVVTPTTTTVAPTGVQ 556
            ...||          ..:.||       |.|....:.:...||
Zfish   244 ESKRTSPLRVDVPPFATSPHQIINKPFFQSPRSFPESLRRYNS---------------------- 286

  Fly   557 GGSEGASSTANNVKAATAAVVAELAATVGGSDEVQDDDEQEDEFESDRRVGFQVEGE--DDDFYK 619
             ..:...:..||..|.|                     ..:.||:|.|.   ..||:  |.:.|.
Zfish   287 -DPKSYPTFFNNNYACT---------------------RNDKEFDSPRS---HDEGDLSDSEAYT 326

  Fly   620 RP-PKLHRRDTPHHLKNKRVQHLTDKQASEILANALASQERNDTTPQHSLSGKVTSPIEE-EEQL 682
            .. |:.|.:||...|.    ....:.||.|:               .:|:|      ::| ::|.
Zfish   327 DSYPESHPKDTETDLN----PAFEEPQAYEM---------------NYSMS------MDECDDQQ 366

  Fly   683 EVEQEQQQQ----QQQHPFDSSLSPISAGKTAEASTDPDNLDGVTELRLEQYEIHIERTAAGLGL 743
            ::|:|....    .:.|.:|.     .:|..||:              ..:...|:.:|::...|
Zfish   367 DLEEEPNPHSAVGSRLHHYDE-----QSGDEAES--------------FGRSRAHLRKTSSSTSL 412

  Fly   744 SIAGGKGSTPFKGDDDGIFISRVTEAGPADLAGLKVGDKVIKVNGIVVVDADHYQAVQVLKACGA 808
            .:      .....||:   .|.:|: ...||.. :|.|          |.....|..:..||.|.
Zfish   413 PL------EVHPQDDE---TSEMTQ-NSTDLQE-EVED----------VPEKQDQITESCKATGD 456

  Fly   809 VLVLVVQREVTRLIGHPVFSEDGSVSQISVET--RPLVADAPPAASISHERYIPAPIEIVPQQQH 871
            .:.|.: |::..           ::.::..:|  .|.:.|.           |..|:.::
Zfish   457 AVSLAI-RDIKE-----------AIEEVKTKTVRSPYMPDK-----------ITEPVWVM----- 493

  Fly   872 LQQQQQQPIQQVAP-THSY---------SGNVFATPTAAQTVQPAVSAAPNGLLLNGREAPLSYI 926
              :|...|:::..| .|||         |...:|.|  .|..:|.:.|..:|:|...::.
Zfish   494 --RQDVSPVEESHPQIHSYPQSPCQISQSSPQYAAP--IQDAEPPLGAESSGVLHQDQDQ----- 549

  Fly   927 QLHTTLIRDQIGQGLGFSIAGGKGSPPFKD---DCDGIFISRITEGGLAYRDGKIMVGDRVMAIN 988
            :|...:..::..:.|.       ..|.:.|   .||
Zfish   550 ELCPNVPSEEQRKSLA-------SFPTYVDVPGPCD----------------------------- 578

  Fly   989 GNDMTEAHHDAAVACLTEPQRFV-RLVLQREYRGPLEPPTSPRSPAVLNSLSPSGYLANRPANFS 1052
                              |:..: .::....|.|         |..:|:..:|:.....:.|..:
Zfish   579 ------------------PEDLIDGIIFAANYLG---------STQLLSERTPTKSARMQQAQEA 616

  Fly  1053 RSVVEVEQPYKYNTLATTTPTPKPTVPASISNNNNT---LPSS-------KTNGFATAAAATIDS 1107
            .|.|...|                 ..|.|.|...|   .||.       .|......:|.|.|:
Zfish   617 MSRVRTAQ-----------------AQAKIRNKQGTESGPPSCTEVDLFISTQRIKVLSAYTQDT 664

  Fly  1108 STGQPVPAPRRTNSVPMGDGDIG--------------AGSTTSGDSGEAQPSSLRPLTSDDFQ-A 1157
            ....|:    ||.|.   ..|||              ..:..:.|:.|.|.::  |...|..| .
Zfish   665 MMDHPL----RTISY---IADIGNMVVLMARRKMIRSQSAQENLDTAETQHTN--PARDDRRQYK 720

  Fly  1158 MIPAHFLSGGSQHQVHVARPNEVGVSAVTVNVNKPQPDLPMFPAAPTELGRVT----ETITKSTF 1218
            ||            .||....:..:.|.::.        ..|..|..|..|..    |.:::..:
Zfish   721 MI------------CHVFESEDAQLIAQSIG--------QAFSVAYQEFLRANGIDPEDLSQREY 765

  Fly  1219 TETVMTRITDNQLAEPLI----SE---EVVLPKNQGS-LGFSIIGGTDHSCVPFGTREPGIFISH 1275
            ::.:.|:...|   :.||    ||   :|.:.|.:|. ||..|:..      .:|:..|.:.|:.
Zfish   766 SDLLNTQDMYN---DDLIHFSKSENCRDVYIEKQKGEILGVVIVES------GWGSILPTVIIAS 821

  Fly  1276 IVPGGIASKCGKLRMGDRILKVNEAD---VSKATHQDAVLELLKPGDEIKLTIQHDPLPPGFQEV 1337
            ::.||.|:|.|:|.:||:|:.||...   :..:|.| ::::.||....||:.|..  .|| ...|
Zfish   822 LMHGGPAAKSGRLNIGDQIMTVNGTSLVGLPLSTCQ-SIIKGLKSQSRIKMNIVR--CPP-VTMV 882

  Fly  1338 LLSKAE-GERLGMHIKGGLNGQRGNPADPSDEGVFVSKINSVGAARRDGRLKVGMRLLEVNGHSL 1401
            |:.:.: ..:||..::.|:                :..:...|.|.|.| ::||.|::|:||.|:
Zfish   883 LIRRPDLRYQLGFSVQNGI----------------ICSLMRGGIAERGG-VRVGHRIIEINGQSV 930

  Fly  1402 LGASHQDAVNVLRNAGNEIQL 1422
            :...|:..|::|.||..||.:
Zfish   931 VATPHEKIVHILSNAVGEIHM 951

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064
		leucine-rich repeat	18..38	CDD:275380
		LRR_8	37..95	CDD:290566
		leucine-rich repeat	39..61	CDD:275380
		leucine-rich repeat	62..84	CDD:275380
		LRR_8	84..138	CDD:290566
		leucine-rich repeat	85..107	CDD:275380
		leucine-rich repeat	108..130	CDD:275380
		LRR_8	129..187	CDD:290566
		leucine-rich repeat	131..153	CDD:275380
		leucine-rich repeat	154..176	CDD:275380
		leucine-rich repeat	177..199	CDD:275380
		LRR_8	198..256	CDD:290566
		leucine-rich repeat	200..222	CDD:275380
		leucine-rich repeat	223..245	CDD:275380
		LRR_8	267..325	CDD:290566
		leucine-rich repeat	269..289	CDD:275380
		leucine-rich repeat	292..314	CDD:275380
		leucine-rich repeat	315..337	CDD:275380
		LRR_4	337..375	CDD:289563
		leucine-rich repeat	361..382	CDD:275380
		PDZ	728..816	CDD:214570	17/87 (20%)
		PDZ_signaling	931..1016	CDD:238492	6/88 (7%)
		PDZ	1239..1329	CDD:214570	27/93 (29%)
		PDZ_signaling	1336..1425	CDD:238492	23/88 (26%)
apba1b	XP_005155643.1	PTB_X11	579..757	CDD:269919	42/232 (18%)
		PDZ	790..873	CDD:278991	26/89 (29%)
		PDZ_signaling	879..952	CDD:238492	23/90 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910