DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scrib and lrrc8db

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	NP_001070848.1	Gene:	lrrc8db / 563923	ZFINID:	ZDB-GENE-061013-487	Length:	841	Species:	Danio rerio

Alignment Length:	368	Identity:	105/368 - (28%)
Similarity:	165/368 - (44%)	Gaps:	81/368 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 HC--SLPQVPEEILR-YSRTLEELFLDANHIRDLPKNFFRLHRLRKLGLSDNEIGRLPPDIQNFE 83
            ||  .:.|.....|| :.|.|...|.|   :.::|...:.|..||:|.|    :|.|     |.|
Zfish   505 HCPAKVEQTAFSFLRDHLRCLHVKFTD---VAEIPTWVYMLKNLRELYL----VGNL-----NSE 557

  Fly    84 N--LVELDVSRNDIPDIPDDIKHLQSLQVADFSSNPIPKLPSGFSQLK----------------- 129
            |  ::.|:..|        |::||:.|.:   .|| :.|:|:..:.|.
Zfish   558 NNKMIGLESLR--------DLRHLKVLHL---KSN-LTKIPTNITDLSPHLIKLVVHNDGTKLLV 610

  Fly   130 --------NLTVLGLNDMSLTTLPADFGSLTQLESLELRENLLKHLPETIS--QLTKLKRLDLGD 184
                    ||:.|.|::..|..:|....|||.|:.|:|:.|.::.:.|.||  .|.:|..|.|..
Zfish   611 LNSLKKMMNLSDLELHNCELERIPHAIFSLTNLQELDLKSNNIRTIEEVISFQHLKRLNCLKLWH 675

  Fly   185 NEIEDLPPYLGYLPGLHELWLDHNQLQRLPPELGLLTKLTYLDVSENRLEELPNEISGLVSLTDL 249
            |:|..:|..:.::..|..|:|.||:|:.||..|..|.||.|||||.|.:..:|.|:..|.:|...
Zfish   676 NKIISIPLSISHVKNLEFLYLSHNKLESLPTTLFNLLKLRYLDVSHNSIVVIPPEVGFLQNLQHF 740

  Fly   250 DLAQNLLEALPDGIAKLSRLTILKLDQNRLQRLNDTLGNCENMQELILTENFLSELPASIGQMTK 314
            .:..|.:|.:|..:.|                       |..::.|.|..|.:|.||..|||:.:
Zfish   741 AITGNKVEVVPKQLFK-----------------------CTKLRTLSLGHNCISSLPEKIGQLLQ 782

  Fly   315 LNNLNVDRNALEYLPLEIGQCANL--GVLSLRDNKLKKLPPEL 355
            |.:|.:..|.|:.||.::|||..|  ..|::.|:....||.|:
Zfish   783 LTHLELKGNCLDRLPAQLGQCRLLRRNGLTVEDHLFDSLPLEV 825

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064	80/292 (27%)
		leucine-rich repeat	18..38	CDD:275380	5/18 (28%)
		LRR_8	37..95	CDD:290566	17/59 (29%)
		leucine-rich repeat	39..61	CDD:275380	5/21 (24%)
		leucine-rich repeat	62..84	CDD:275380	7/21 (33%)
		LRR_8	84..138	CDD:290566	16/80 (20%)
		leucine-rich repeat	85..107	CDD:275380	5/21 (24%)
		leucine-rich repeat	108..130	CDD:275380	6/46 (13%)
		LRR_8	129..187	CDD:290566	21/84 (25%)
		leucine-rich repeat	131..153	CDD:275380	7/21 (33%)
		leucine-rich repeat	154..176	CDD:275380	8/23 (35%)
		leucine-rich repeat	177..199	CDD:275380	6/21 (29%)
		LRR_8	198..256	CDD:290566	23/57 (40%)
		leucine-rich repeat	200..222	CDD:275380	10/21 (48%)
		leucine-rich repeat	223..245	CDD:275380	10/21 (48%)
		LRR_8	267..325	CDD:290566	13/57 (23%)
		leucine-rich repeat	269..289	CDD:275380	0/19 (0%)
		leucine-rich repeat	292..314	CDD:275380	9/21 (43%)
		leucine-rich repeat	315..337	CDD:275380	9/21 (43%)
		LRR_4	337..375	CDD:289563	6/21 (29%)
		leucine-rich repeat	361..382	CDD:275380
		PDZ	728..816	CDD:214570
		PDZ_signaling	931..1016	CDD:238492
		PDZ	1239..1329	CDD:214570
		PDZ_signaling	1336..1425	CDD:238492
lrrc8db	NP_001070848.1	Pannexin_like	1..367	CDD:289311
		leucine-rich repeat	498..521	CDD:275380	5/15 (33%)
		leucine-rich repeat	522..541	CDD:275380	5/21 (24%)
		LRR_RI	<544..821	CDD:238064	91/320 (28%)
		leucine-rich repeat	545..572	CDD:275380	12/43 (28%)
		leucine-rich repeat	573..619	CDD:275380	7/49 (14%)
		leucine-rich repeat	597..611	CDD:275380	0/13 (0%)
		leucine-rich repeat	620..642	CDD:275380	7/21 (33%)
		LRR_8	641..701	CDD:290566	20/59 (34%)
		leucine-rich repeat	643..667	CDD:275380	8/23 (35%)
		leucine-rich repeat	668..690	CDD:275380	6/21 (29%)
		LRR_8	689..747	CDD:290566	23/57 (40%)
		LRR_4	689..729	CDD:289563	18/39 (46%)
		leucine-rich repeat	691..713	CDD:275380	10/21 (48%)
		leucine-rich repeat	714..736	CDD:275380	10/21 (48%)
		LRR_8	736..791	CDD:290566	17/77 (22%)
		leucine-rich repeat	737..759	CDD:275380	6/44 (14%)
		leucine-rich repeat	760..782	CDD:275380	9/21 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910