DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scrib and PARD3

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	NP_062565.2	Gene:	PARD3 / 56288	HGNCID:	16051	Length:	1356	Species:	Homo sapiens

Alignment Length:	1609	Identity:	316/1609 - (19%)
Similarity:	561/1609 - (34%)	Gaps:	516/1609 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   627 RDTPHHLKNKRVQH----LTDKQASEILANALASQER-----NDTTPQHSLSGKVTSPIEEEEQL 682
            :|..:.::..|::|    :.|  ..:||.:....::|     ::..|.|...|...|
Human    40 KDPNYWIQVHRLEHGDGGILD--LDDILCDVADDKDRLVAVFDEQDPHHGGDGTSAS-------- 94

  Fly   683 EVEQEQQQQQQQHPFDSSL--SPISAGKTAEASTDPDNLDGVTELRLEQYEIHIERTA----AGL 741
                 ....|....|.|.|  :.:||.:..:|:::.:....|....:   .:|:.|::    .||
Human    95 -----STGTQSPEIFGSELGTNNVSAFQPYQATSEIEVTPSVLRANM---PLHVRRSSDPALIGL 151

  Fly   742 GLSIAGGKGST-------PFKGDDDGIFISRVTEAGPADLAGLKVGDKVIKVNGIVVVDADHYQA 799
            ..|::....|:       |.:......|:.:.|...|      |..|:         ...::|::
Human   152 STSVSDSNFSSEEPSRKNPTRWSTTAGFLKQNTAGSP------KTCDR---------KKDENYRS 201

  Fly   800 VQVLKACGAVLVLVVQREVTRLIGHPVFSEDGSVSQISVETRPLVADAPPAASISHERYIPAPIE 864
                          :.|:.:.....  |..|.:.|.:|. :.|:|.                  :
Human   202 --------------LPRDTSNWSNQ--FQRDNARSSLSA-SHPMVG------------------K 231

  Fly   865 IVPQQQHLQQQQQQPIQQVAPT-HSYSG-----NVFATPTAAQTVQPAVSAAPNGLLLNGREAPL 923
            .:.:|:..:...::...:|.|. |:.:|     | |:.....:.|:......|.|
Human   232 WLEKQEQDEDGTEEDNSRVEPVGHADTGLEHIPN-FSLDDMVKLVEVPNDGGPLG---------- 285

  Fly   924 SYIQLHTTLIRDQIGQGLGFSIAGGKGSPPFKDDCDGIFISRITEGGLAYRDGKIMVGDRVMAIN 988
                :|.          :.||..||:..        |:.:.|:.:||.|..:......|.::.||
Human   286 ----IHV----------VPFSARGGRTL--------GLLVKRLEKGGKAEHENLFRENDCIVRIN 328

  Fly   989 GNDMTEAHHDAAVACLTEPQRFVRLVLQREYRGPLEPPTSPRSPAVLNSLSPSGYLANRPANFSR 1053
            ..|:.....:.|               |..:|..:      |:|.:...:.|:   ||:
Human   329 DGDLRNRRFEQA---------------QHMFRQAM------RTPIIWFHVVPA---ANK------ 363

  Fly  1054 SVVEVEQPYKYNTLATTTPTPKPTVPASISNNNNTLPSSKTNGFATAAAATIDSSTGQPVPAPRR 1118
                 ||   |..|             |.|..||...|.     .:..:..||:         |.
Human   364 -----EQ---YEQL-------------SQSEKNNYYSSR-----FSPDSQYIDN---------RS 393

  Fly  1119 TNSVPMGDGDIGAGSTTSGDSGEAQPSSLRPLTSDDFQAMIPAHFLSGGSQHQVHVARPNEVGVS 1183
            .||         ||..|.    :..|....|....|..:.:|            |.|.|:
Human   394 VNS---------AGLHTV----QRAPRLNHPPEQIDSHSRLP------------HSAHPS----- 428

  Fly  1184 AVTVNVNKPQPDLPMFPAAPTELGRVTETITKSTFTETVMTRITDNQLAEPLISEEVVLPKNQGS 1248
                  .||       |:||.       :..::.|:.||.:.....::.:.|   .:.|.|....
Human   429 ------GKP-------PSAPA-------SAPQNVFSTTVSSGYNTKKIGKRL---NIQLKKGTEG 470

  Fly  1249 LGFSI------IGGTDHSCVPFGTREPGIFISHIVPGGIASKCGKLRMGDRILKVNEAD-VSKAT 1306
            |||||      |||:    .|       |::.:|:|.|.|.:.|:|:.|||:::||..| |.|:
Human   471 LGFSITSRDVTIGGS----AP-------IYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKS- 523

  Fly  1307 HQDAVLELLK---------------------------------------PGDEIKLTIQHDPLPP 1332
             |:.|:.||:                                       ..::|.||      |.
Human   524 -QEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNAEPSQMQIPKETKAEDEDIVLT------PD 581

  Fly  1333 GFQEVL-----LSKAEGERLGMHIKGGLNGQRGNPADPSDEGVFVSKINSVGAARRDGRLKVGMR 1392
            |.:|.|     |:.:....||:.:||  |..:.|.|   |.|:||..|.:.|||.:||||:|..:
Human   582 GTREFLTFEVPLNDSGSAGLGVSVKG--NRSKENHA---DLGIFVKSIINGGAASKDGRLRVNDQ 641

  Fly  1393 LLEVNGHSLLGASHQDAVNVLRNA----GNE---IQLVVCKGYDKSNLIHSIGQAGGMSTGFNSS 1450
            |:.|||.||||.::|||:..||.:    ||:   |||:|.:...|.|.:.|.|...|......:
Human   642 LIAVNGESLLGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIET- 705

  Fly  1451 ASCSGGSRQGSRASETGSE-LSQSQS----VSSLDHEEDE-------RLRQDFDVFASQKPDAQQ 1503
             :.....|:.|.:..:|.| |.:|.|    :|.:..|..:       .:.||..|...   |.:.
Human   706 -ALDDRERRISHSLYSGIEGLDESPSRNAALSRIMGESGKYQLSPTVNMPQDDTVIIE---DDRL 766

  Fly  1504 PTGPSVLAAAAAMVHGASSPTPPAATSNITPLPTAAAVASADLT-APDTPAT------------- 1554
            |..|..|:..::   .:|.......|::......||...|||.: :||....
Human   767 PVLPPHLSDQSS---SSSHDDVGFVTADAGTWAKAAISDSADCSLSPDVDPVLAFQREGFGRQSM 828

  Fly  1555 ---QTVALIHAEQQAHQQQQQTQLAPLGQEKSTQEKVLEIVRAADAFTTVPP-----KSPSEHHE 1611
               :|.....|.|....:.::::...||....|:...::..:|......|.|     ||.|....
Human   829 SEKRTKQFSDASQLDFVKTRKSKSMDLGIADETKLNTVDDQKAGSPSRDVGPSLGLKKSSSLESL 893

  Fly  1612 QDKIQKTTTVVISKHTLDTNPTTPTTPAAPLSIAGA---ESANSA---GAPSPAVPASTPG---- 1666
            |..:.:.|          .|...|.....|..|.|.   ||..:|   ....|||.....|
Human   894 QTAVAEVT----------LNGDIPFHRPRPRIIRGRGCNESFRAAIDKSYDKPAVDDDDEGMETL 948

  Fly  1667 ----------------SAPVLPAVAVQTQTQTTSTEKDEEEESQLQSTPASRDGAEEQQEEVRAK 1715
                            :|...|:.:::.|......:.|:.:..:.::....:...::::::::||
Human   949 EEDTEESSRSGRESVSTASDQPSHSLERQMNGNQEKGDKTDRKKDKTGKEKKKDRDKEKDKMKAK 1013

  Fly  1716 PTPTKVPKSVSDKKRFFESAMEDQHKPTQKTDKVFSFLSKDEVEKLRQEEERKIATLR--RDKNS 1778
               ..:.|.:.|..||.:...:|:.:.|.|.....||.|::|..:::||:||..|..|  |::.:
Human  1014 ---KGMLKGLGDMFRFGKHRKDDKIEKTGKIKIQESFTSEEERIRMKQEQERIQAKTREFRERQA 1075

  Fly  1779 RLLDAANDNIDKDAAQQRTKSNSNSSSGDDND-----DSDQEEGIARGDSVDNAALGHFDDAEDM 1838
            |         ::|.|:.:   :.:.:.|.|::     .|..|..:|......:...||..||
Human  1076 R---------ERDYAEIQ---DFHRTFGCDDELMYGGVSSYEGSMALNARPQSPREGHMMDA--- 1125

  Fly  1839 RTAQSLASTMPHAPSKIPKQKLKAKQIESSLPTPT----------------------------AL 1875
                      .:|..|.|:.. |...::|:..||:                            :.
Human  1126 ----------LYAQVKKPRNS-KPSPVDSNRSTPSNHDRIQRLRQEFQQAKQDEDVEDRRRTYSF 1179

  Fly  1876 DPPKPSLLP-----KPKVKVVIPPALQQRLKQQQVQQQQQQH----QQSQPEEPSIPEEEYHQQP 1931
            :.|.|:..|     :..|.|.:....|::.:::..||.|:|:    :||:....|:.::.:.|..
Human  1180 EQPWPNARPATQSGRHSVSVEVQMQRQRQEERESSQQAQRQYSSLPRQSRKNASSVSQDSWEQNY 1244

  Fly  1932 EP--------DSPSAA----------GGSRIPVRTLKAERRALTLAARQSGLSVEEYLKRLETQD 1978
            .|        ::|..:          ||.....|.:...:..|    ||.....|:.:|:   |.
Human  1245 SPGEGFQSAKENPRYSSYQGSRNGYLGGHGFNARVMLETQELL----RQEQRRKEQQMKK---QP 1302

  Fly  1979 DKESPA-----------SPTTPTGKSRSMINAEKRASWRAARLRSLEQG 2016
            ..|.|:           |...|.|..|..:........|..||::.|:|
Human  1303 PSEGPSNYDSYKKVQDPSYAPPKGPFRQDVPPSPSQVARLNRLQTPEKG 1351

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064
		leucine-rich repeat	18..38	CDD:275380
		LRR_8	37..95	CDD:290566
		leucine-rich repeat	39..61	CDD:275380
		leucine-rich repeat	62..84	CDD:275380
		LRR_8	84..138	CDD:290566
		leucine-rich repeat	85..107	CDD:275380
		leucine-rich repeat	108..130	CDD:275380
		LRR_8	129..187	CDD:290566
		leucine-rich repeat	131..153	CDD:275380
		leucine-rich repeat	154..176	CDD:275380
		leucine-rich repeat	177..199	CDD:275380
		LRR_8	198..256	CDD:290566
		leucine-rich repeat	200..222	CDD:275380
		leucine-rich repeat	223..245	CDD:275380
		LRR_8	267..325	CDD:290566
		leucine-rich repeat	269..289	CDD:275380
		leucine-rich repeat	292..314	CDD:275380
		leucine-rich repeat	315..337	CDD:275380
		LRR_4	337..375	CDD:289563
		leucine-rich repeat	361..382	CDD:275380
		PDZ	728..816	CDD:214570	13/98 (13%)
		PDZ_signaling	931..1016	CDD:238492	14/84 (17%)
		PDZ	1239..1329	CDD:214570	33/135 (24%)
		PDZ_signaling	1336..1425	CDD:238492	41/100 (41%)
PARD3	NP_062565.2	DUF3534	1..146	CDD:288873	21/123 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	81..100		4/31 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	154..262		21/157 (13%)
		PDZ_signaling	272..347	CDD:238492	20/121 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	408..448		13/76 (17%)
		PDZ_signaling	465..544	CDD:238492	29/91 (32%)
		PDZ_signaling	588..681	CDD:238492	39/97 (40%)
		Interaction with PRKCI and PRKCZ. /evidence=ECO:0000250\|UniProtKB:Q9Z340	712..936		47/239 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	865..886		3/20 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	932..1025		12/95 (13%)
		Interaction with FRMD4A. /evidence=ECO:0000250\|UniProtKB:Q99NH2	935..1356		83/453 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1129..1356		42/231 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910