DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scrib and grip2b

DIOPT Version :9

Sequence 1:	NP_001163746.1	Gene:	scrib / 44448	FlyBaseID:	FBgn0263289	Length:	2585	Species:	Drosophila melanogaster
Sequence 2:	XP_021325304.1	Gene:	grip2b / 562290	ZFINID:	ZDB-GENE-070705-172	Length:	1086	Species:	Danio rerio

Alignment Length:	1197	Identity:	248/1197 - (20%)
Similarity:	407/1197 - (34%)	Gaps:	385/1197 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   697 FDSSLSPISAGKTAEASTDPDN-----------LDGVTELRLEQYEIHIERTAAGLGLSIAGGKG 750
            ||.  .|.|.|.  :.||.|:|           |.|||.:.|      |::..:.|||:|:||.
Zfish    13 FDD--GPYSKGN--KDSTGPENSLTSRRQSIPELRGVTLVEL------IKKEGSTLGLTISGGT- 66

  Fly   751 STPFKGDDDGIFISRVTEAGPADLAG----LKVGDKVIKVNGIVVVDADHYQAVQVLKACGAVLV 811
                  |.||  ..||:...|..||.    |.|||.:..||||.:....|.:.:.:||..|..:|
Zfish    67 ------DKDG--KPRVSNLRPGGLAARSDQLNVGDYIKSVNGINLTKLRHDEIISLLKNVGERVV 123

  Fly   812 LVVQREVTRLIGHPVFSEDGSVSQISVETRPLVADAPPAASISHERYIPAPIEIVPQQQHLQQQQ 876
            |.|:.|:                             |.||..|....|...|||..|::
Zfish   124 LEVEYEL-----------------------------PSAAPDSTSGVISKTIEICLQKE------ 153

  Fly   877 QQPIQQVAPTHSYSGNVF--------------ATPTAAQTVQPAVSAAPNGLLLNG-REAPLSYI 926
                          ||.|              :.|.....|:|...|...|.|.:| |...:..:
Zfish   154 --------------GNSFGFVMRGGAHEDWHKSRPLVVTHVRPGGPADREGTLKSGDRILSVDGV 204

  Fly   927 QLHTT------LIRDQIGQGLGF----------SIAGGKG------------------SPPFKDD 957
            .||:.      ::..|.||...|          |:....|                  :.....:
Zfish   205 VLHSATHSDALVVLTQCGQEALFQIEYDVSIMDSVTNASGPLLVEIAKAPGASLGVTLTTALHRN 269

  Fly   958 CDGIFISRITEGGLAYRDGKIMVGDRVMAINGNDMTEAHHDAAVACL-----TEPQRFVRLVLQR 1017
            ...|.|.:|..|.:..|.|.:.|||.:::|:|   |...|.:.:...     |..|..:.::...
Zfish   270 KQAIVIDKIKPGSVVDRSGALHVGDHILSIDG---TSTEHCSLLEATQLLASTSDQTKLEILPAH 331

  Fly  1018 EYRGPLEPPTSPRSPAVLNSLSPSGYLANRPANFSRSVVEVEQPYKYNTLATTTPTPKPTVP--- 1079
            :.|.|.:|..:.:   |..|..|  :..:...|:..|    :.|....|...|:.:..|:..
Zfish   332 QTRLPGKPQDTVK---VQKSDHP--HCWDPCVNYCHS----QHPGHCKTSTWTSASSNPSSSQDY 387

  Fly  1080 -ASISNNNNTLPSSKTNGFATAAAATIDSSTGQPVPAPR-------------RTNSVPMGDGDIG 1130
             .|:..:|.:..|:.|:|..:..::|:..:.  |..:||             :::||.:....:|
Zfish   388 CKSVVCSNFSPGSTTTSGMTSQGSSTLPRAA--PPMSPRNSMLKRRQRKKEHKSSSVSLASSSVG 450

  Fly  1131 -AGSTTSGDSGEAQPSSLR--PLTSDDFQAMIPAHFLSGG--------SQHQVHVARPN------ 1178
             .|.....:|.|.   :||  ||.....|       |.||        :...:....|:
Zfish   451 PGGQIVHTESSEV---TLRGDPLNGFGVQ-------LQGGIFATETLSAPPLIRFIEPDSSAERC 505

  Fly  1179 ---EVGVSAVTVNVNKPQPDLPMFPAAPTELGRVTET---ITKSTFTETVMTRITDNQLAEPLIS 1237
               :||...:::|            ..|||.|.:.|.   :..:.....|...| :..:||.::.
Zfish   506 GLLQVGDRVLSIN------------GIPTEDGTLEEANQLLRDAALANKVSLEI-EFDVAESVVP 557

  Fly  1238 E----EVVLPKNQG-SLGFSIIGGTDHSCVPFGTREPG--IFISHIVPGGIASKCGKLRMGDRIL 1295
            .    .|.|.|.:| .||.:|          ..:::||  :.||.|..|.:|.:.|.|..||::|
Zfish   558 SSGTFHVKLQKKRGVELGITI----------SASKKPGEPLIISDIKKGSMAHRTGTLEPGDKLL 612

  Fly  1296 KVNEADVSKATHQDAVLELLKPGDEIKLTIQHDPLPPGFQE-------VLLSKAEGERLGMHIKG 1353
            .::...:...:.:||...|.:..|.:||.|:.|......||       .:..|..|..||:.|.|
Zfish   613 AIDNIRLENCSMEDAAQILQQSEDLVKLKIRKDEDNSDEQESSGSIIYTVELKRYGGPLGITISG 677

  Fly  1354 GLNGQRGNPADPSDEGVFVSKINSVGAARRDGRLKVGMRLLEVNGHSLLGASHQDAVNVLRNAGN 1418
                 ...|.||    :.:|.:...|.|.|.|.:.||.|:|.:|..||.|....:|:::|:.||.
Zfish   678 -----TEEPFDP----IIISGLTKRGLAERTGAIHVGDRILAINSVSLKGKPLSEAIHLLQMAGE 733

  Fly  1419 EIQLVVCKGYD------KSNLIHSIGQAGGMSTGFNSSASCSGGSRQGSRASETGSELSQSQSVS 1477
            .:.|.:.|..|      |.|.:.                         :..|:...|::.||..:
Zfish   734 TVTLKIKKQADSPDEKNKENDLE-------------------------NDLSDNEDEMTDSQKTN 773

  Fly  1478 SLDHEEDERLRQDFDVFASQKPDAQQP----TGPSV---LAAAAAMVHGA--------------- 1520
            .|.           |::::..|.....    .|..:   .::..|.:|.|
Zfish   774 KLS-----------DIYSTTIPSVDSAMESWDGSGIDAGYSSQGAFIHQAAGIALHPHEWRNTKQ 827

  Fly  1521 -SSPTPPAATSNITPLPTAAAVASADLTAPDTPATQTVALIHAEQQAHQQQQQTQLAPLGQEKST 1584
             :|..||....|........:....|..|..:..|...||:..::.:...|....|...||.
Zfish   828 RNSTPPPTRRKNYPFSDGGFSEDDWDKAAGYSSQTHADALLMEQEDSFWCQALEDLETCGQS--- 889

  Fly  1585 QEKVLEIVRAADAFTTVPPKSPSEHHEQDKIQKTTTVVISKHTLDTNPTTPTTPAAPLSIAGAES 1649
                 |::|..:|                                   :..|..|..|.:.|.:
Zfish   890 -----ELLREIEA-----------------------------------SIMTGSALSLGVEGGK- 913

  Fly  1650 ANSAGAPSPAVPASTPGSAPVLPAVAVQTQTQTTSTEKDEEEESQLQSTPASRDGAEEQQEEVRA 1714
                   :...|.:.|..:|:..:..:..:|:..||.:..|:      |..||...||.|:.:
Zfish   914 -------THVDPVNQPHLSPLRKSPHLFNETKNKSTLRMSEK------TWESRRIKEEIQDIL-- 963

  Fly  1715 KPTPTKVPK--------------SVSD 1727
            .|||.::.|              ||||
Zfish   964 SPTPLELHKVTVMKDPESDDFGFSVSD 990

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrib	NP_001163746.1	LRR_RI	13..283	CDD:238064
		leucine-rich repeat	18..38	CDD:275380
		LRR_8	37..95	CDD:290566
		leucine-rich repeat	39..61	CDD:275380
		leucine-rich repeat	62..84	CDD:275380
		LRR_8	84..138	CDD:290566
		leucine-rich repeat	85..107	CDD:275380
		leucine-rich repeat	108..130	CDD:275380
		LRR_8	129..187	CDD:290566
		leucine-rich repeat	131..153	CDD:275380
		leucine-rich repeat	154..176	CDD:275380
		leucine-rich repeat	177..199	CDD:275380
		LRR_8	198..256	CDD:290566
		leucine-rich repeat	200..222	CDD:275380
		leucine-rich repeat	223..245	CDD:275380
		LRR_8	267..325	CDD:290566
		leucine-rich repeat	269..289	CDD:275380
		leucine-rich repeat	292..314	CDD:275380
		leucine-rich repeat	315..337	CDD:275380
		LRR_4	337..375	CDD:289563
		leucine-rich repeat	361..382	CDD:275380
		PDZ	728..816	CDD:214570	30/91 (33%)
		PDZ_signaling	931..1016	CDD:238492	21/123 (17%)
		PDZ	1239..1329	CDD:214570	26/92 (28%)
		PDZ_signaling	1336..1425	CDD:238492	28/95 (29%)
grip2b	XP_021325304.1	PDZ_signaling	45..127	CDD:238492	32/96 (33%)
		PDZ	144..232	CDD:214570	21/107 (20%)
		PDZ_signaling	245..328	CDD:238492	15/85 (18%)
		PDZ_signaling	462..548	CDD:238492	20/108 (19%)
		PDZ_signaling	561..643	CDD:238492	25/91 (27%)
		PDZ_signaling	659..740	CDD:238492	27/89 (30%)
		Peptidase_S41	672..>841	CDD:321971	43/213 (20%)
		PDZ_signaling	970..1050	CDD:238492	5/21 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910