DRSC/TRiP Functional Genomics Resources

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Protein Alignment scrib and si:dkey-92j12.5

DIOPT Version :9

Sequence 1:NP_001163746.1 Gene:scrib / 44448 FlyBaseID:FBgn0263289 Length:2585 Species:Drosophila melanogaster
Sequence 2:XP_021332028.1 Gene:si:dkey-92j12.5 / 560912 ZFINID:ZDB-GENE-090313-354 Length:1860 Species:Danio rerio


Alignment Length:1708 Identity:348/1708 - (20%)
Similarity:590/1708 - (34%) Gaps:500/1708 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    69 DNEIGRLPPDIQNFENLVELDVSRNDIPDIPDDIKHLQSLQV--------ADFSSNPIPKLPSGF 125
            |..|| :...|.:.:..::.|.|:.:    |::|..:...||        :...:...|...:.|
Zfish   349 DGHIG-IGGHIISVDGKIQHDCSKRN----PEEILLITGQQVELHLPKKCSPCETQTTPSTSTNF 408

  Fly   126 SQLKNLTVLGLNDMSL--------TTLPADFGSLTQLESLELRENLLKH----------LPETIS 172
            .  :.||.|||....|        ..||.  |.:...|.|:.  |..|.          |.:|.|
Zfish   409 Q--RPLTPLGLLPPPLPPRLPEQKPVLPP--GKVFYTERLDF--NFNKECFRSSQTCCLLSKTES 467

  Fly   173 QLTKLKRLDLGDNEIEDLPPYLGYLPGLHELWLDHNQLQRLPPELGLLTKLTYLDVSENRLEELP 237
            :..|.....|.|:|.:          .|.|.|     ..:|.|:..:|.         .::|:. 
Zfish   468 RNHKSSCCKLSDDEEK----------SLKEKW-----QSKLGPQYEVLV---------TQVEKF- 507

  Fly   238 NEISGL-VSLTDLDLAQNLLEALPDGIAKLSRLTILK-----LDQNRLQRLNDTLGNCENMQELI 296
            .|.||| |||...:....:...||:|  .|.:..|:.     ::.|....:.:|      .:|::
Zfish   508 IESSGLGVSLEAKEGHHYICSILPEG--PLGQTGIIHPGDELIEVNGFSLIGET------HKEVV 564

  Fly   297 LTENFLSELPASIGQM-TKLNNLNVDRN-------ALEYLPLEIGQCA--NL--GVLSLRDNKLK 349
               :.|.|||.::..: ::|....|...       .|:.|..|..:.|  |:  .|.:||:..||
Zfish   565 ---SLLKELPMNVCVVCSRLIPPRVSEEEDDDVQLTLKELLAEFNEKAEQNIFGSVFALREEDLK 626

  Fly   350 KLPPELGNCTVLHVLDVSGNQLLYLPYSLVNLQLKAVWLSENQSQPLLTFQPDTDAETGEQVLSC 414
            ...|.|.:                          :|:|.:|.:...|         :.|:..|..
Zfish   627 SEAPVLSH--------------------------QAMWENEIEVYEL---------QKGDSGLGF 656

  Fly   415 YLLPQQEYQPITPARD-------------------LESDSEPF-EEREPSRTVVKFSEEATQEKE 459
            .:|..|:  |:.|.|.                   |..|...| .:.:.|...:..:....:...
Zfish   657 SILDYQD--PVNPGRTVIVIRSLVPGGLADRDGRLLPGDRLMFVNQTDLSHASLAQAVHVLKSTA 719

  Fly   460 TPFVRQNTPHP---KDLKAKAQKL--KVERSRNEEHANLVTLPEENGTKLAETPTETRTIANNHQ 519
            ...||.....|   .|::....::  ......|.:|:...|                    |:|.
Zfish   720 LGTVRIGVTKPLPENDIQDTGAEITGNCHSEHNHQHSTFQT--------------------NSHS 764

  Fly   520 Q----QPHPVQQP---------IVGVNSKQPVVVGVVTPTTTTVAPTGVQGGS------------ 559
            |    :..||..|         :|..||...:.|..:...:..:..:.|.|||            
Zfish   765 QKSKMEAEPVSIPSSGYERTITVVRGNSSLGMTVSALRDGSGIIIRSVVHGGSISKDGRLAVGDG 829

  Fly   560 ----EGASSTANNVKAATAAVVAELAATVGGSDEVQDDDEQEDEFESDRRVGFQVEGEDDDFYKR 620
                .|.|:|  |:..|.|..:....:.:|....|.   .....|....|..:....|:.:.:..
Zfish   830 IVALNGESTT--NLTNAQARAMLRRHSLIGPDLSVM---YVPAAFLDLHRASYSKSKEEMEIHTP 889

  Fly   621 PPKLHRRDTPHHLKNKRVQHLTDKQA---SEILANALASQERNDTTPQHSLSGKVTSPIEEEEQL 682
            ....||..  .:|..|.::.::::|:   .:.:.....::|.|:...:|       |||::.|..
Zfish   890 AAVQHRHS--QNLPFKPLECISEQQSVVDGKGVNGKTQAEEENERIDEH-------SPIKQRENS 945

  Fly   683 EVEQEQQQQQQQHPFDSSLSPISAGKTAEASTDPDNLDGVTELRLEQYEIHIERTAAG---LGLS 744
            :.....|:.:.:.|...|.:.....:..:...|.....|.......|.. .::.:.||   ||.|
Zfish   946 KRLDRDQKVKNEKPALQSENRHEQEREKDRQRDEKETHGRDHTSWSQPR-RVKLSRAGGTCLGFS 1009

  Fly   745 IAGGKGSTPFKGDDD---GIFISRVTEAGP-ADLAGLKVGDKVIKVNGIVVVDADHYQAVQVLKA 805
            :.||:|......:.:   ||||..:.|..| |..:.||.||::::|.||.|.|..|.:||:.::.
Zfish  1010 VFGGRGMGSRLSNGEMRRGIFIKHIAEDSPAAHNSTLKEGDRILQVQGIDVSDFTHEEAVEAIRR 1074

  Fly   806 CGAVLVLVVQREVTRLIGHPVFS------EDGSVSQISVE------------------------T 840
            .|..:.|:||        .|.||      ||..:|:.:.:                        |
Zfish  1075 AGDRVELLVQ--------SPQFSEPDNYLEDDRISKTNSQNHQESEIPNNLSPTFPFSPIPFKRT 1131

  Fly   841 RPLVADAPPAASISHERYIPAPIEIVPQQQHLQQQQQQPIQQVAPTHSYSGNVFATPTAAQT--- 902
            .......||.::.|..:....|.|  .|...:|:..::|......:|.:||.       .||   
Zfish  1132 EDWKLGKPPHSAPSLLKLPCRPDE--TQTDGVQRLPERPPLPEETSHDHSGQ-------EQTSYW 1187

  Fly   903 --VQPAVSAAPNGLLLNGREAPLSYIQLHTTLIRDQIGQGLGFSIAGGKGSPPFKDDCDG---IF 962
              :|....:.|..||:...:.             ...|.|||..::|.      :|...|   :|
Zfish  1188 SRMQQRYGSLPGELLMFDLDC-------------SSHGSGLGLCLSGN------RDGARGRMSVF 1233

  Fly   963 ISRITEGGLAYRDGKIMVGDRVMAINGNDMTEAHHDAAVACLTEPQRFVRLVLQREYRGPLEPPT 1027
            :|.||..|.|..||::.|||.::.|||..:....|..|.|.:......||::|.|......:..:
Zfish  1234 VSEITADGAAAADGRVRVGDELLEINGQVLYGRSHQNATAIINNAPAKVRILLTRNKAVQKQMTS 1298

  Fly  1028 SPRS-----PAVLNS-------------LSPSGYLANRPANFSRSVVEVEQPYKYNTLATTTPTP 1074
            .|..     |.:..|             ||..|.:.......|||         ..:|....|.|
Zfish  1299 GPEKEMDSCPEIYPSVHIDMIAEDQHSVLSQDGRITREDKLKSRS---------SESLNVGLPAP 1354

  Fly  1075 KPTVPASISNNNNTLPSSKT----------NGFATAAAATIDSS----------------TGQPV 1113
               :.|:.::..:..|:|:|          :|.::|..:|.:.|                :..|:
Zfish  1355 ---INATSNHQASCHPASQTPISRCIPPQSSGISSADESTANQSSRIWPHSTSHRAQCSVSSDPL 1416

  Fly  1114 PA---PRRTNSVPMGDGDIGAGSTTSGDSGEAQPSSLRPLTSDDFQAMIPAHFLS-GGSQHQ--- 1171
            ..   |...|:|.:..|..|.|.:..|.             .:....:|..|.:: .|:.|:   
Zfish  1417 TCPIIPGCINTVDICKGTTGLGLSIVGG-------------CNTLLGVIVIHEVNKDGAAHRDGR 1468

  Fly  1172 ----VHVARPNEVGVSAVTVNVNKPQPDLPMFPAAPTELGRVTETITKSTFTETVMTRITDNQLA 1232
                .|:...|.:.:...|     .:..|.:...:|.   ||..:|.:...||......:.....
Zfish  1469 LWAGDHILEVNGIDLRMAT-----HEEALSVLRLSPQ---RVRLSIYRDHVTEKHSKHTSQKHTP 1525

  Fly  1233 E---PLISEEVVLPKNQGSLGFSIIGGTDHSCVPFGTREPGIFISHIVPGGIASKCGKLRMGDRI 1294
            |   .|.:.|:.|...|| ||..|:|..:         :.|||:|.|..||.|...|:|.:||:|
Zfish  1526 EDMWDLFNVELNLQPRQG-LGLCIVGKMN---------DTGIFVSEITRGGAADVDGRLLLGDQI 1580

  Fly  1295 LKVNEADVSKAT--HQDAVLE------LLKP-----------GDEI--------KLTIQHDPLPP 1332
            |.||..|:..|:  |..|:|:      ||:.           ||::        .....||.:..
Zfish  1581 LSVNGEDIRAASQDHASALLQRCSGSVLLEVARFKASSHYSYGDQVGEVDVPLFSCLNTHDSVDG 1645

  Fly  1333 G--FQEVLLSKAEGERLGMHIKGGLNGQRGNPADPSDEGVFVSKINSVGAARRDGRLKVGMRLLE 1395
            .  .:.|.:.|.|.:.:.:.::..|          ...|:::||:::...|.|.|.|::|.|::.
Zfish  1646 NVDIRTVTVQKHECDSVELRVRDTL----------GHAGMYISKLDASTLAARSGLLQLGSRVIS 1700

  Fly  1396 VNGHSLLGASHQDAVNVLRNAGNEIQLVV----CK-----GYDKSNLIHSI-------------- 1437
            :||......|..:|..:|:|:...:.|.|    |.     ..|:|:||||.              
Zfish  1701 INGTQTERLSVAEASFLLKNSSGAVTLQVMPSGCADGASISTDRSSLIHSSPGLSENYTTHNHQS 1765

  Fly  1438 -----------GQAG-GMST--GFNSS----------------ASCSGGSRQGSRASETGSELSQ 1472
                       |.|| |.|.  ||.||                |...|..|:|.:....     .
Zfish  1766 SPQYQTITLERGSAGLGFSIVGGFGSSHGDLPIYVKNIFPKGAAVEDGRLRRGDQLLTV-----N 1825

  Fly  1473 SQSVSSLDHEED-ERLRQ 1489
            .||:..:.|.|. |.|||
Zfish  1826 GQSLEGVTHSEAVEILRQ 1843

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
scribNP_001163746.1 LRR_RI 13..283 CDD:238064 52/245 (21%)
leucine-rich repeat 18..38 CDD:275380
LRR_8 37..95 CDD:290566 6/25 (24%)
leucine-rich repeat 39..61 CDD:275380
leucine-rich repeat 62..84 CDD:275380 4/14 (29%)
LRR_8 84..138 CDD:290566 13/61 (21%)
leucine-rich repeat 85..107 CDD:275380 4/21 (19%)
leucine-rich repeat 108..130 CDD:275380 4/29 (14%)
LRR_8 129..187 CDD:290566 19/75 (25%)
leucine-rich repeat 131..153 CDD:275380 9/29 (31%)
leucine-rich repeat 154..176 CDD:275380 7/31 (23%)
leucine-rich repeat 177..199 CDD:275380 3/21 (14%)
LRR_8 198..256 CDD:290566 14/58 (24%)
leucine-rich repeat 200..222 CDD:275380 6/21 (29%)
leucine-rich repeat 223..245 CDD:275380 5/22 (23%)
LRR_8 267..325 CDD:290566 10/70 (14%)
leucine-rich repeat 269..289 CDD:275380 3/24 (13%)
leucine-rich repeat 292..314 CDD:275380 5/22 (23%)
leucine-rich repeat 315..337 CDD:275380 6/30 (20%)
LRR_4 337..375 CDD:289563 8/39 (21%)
leucine-rich repeat 361..382 CDD:275380 0/20 (0%)
PDZ 728..816 CDD:214570 31/94 (33%)
PDZ_signaling 931..1016 CDD:238492 26/87 (30%)
PDZ 1239..1329 CDD:214570 34/116 (29%)
PDZ_signaling 1336..1425 CDD:238492 21/92 (23%)
si:dkey-92j12.5XP_021332028.1 L27_2 3..58 CDD:312549
PDZ 137..220 CDD:214570
PDZ 231..312 CDD:214570
PDZ_signaling 509..577 CDD:238492 19/78 (24%)
PDZ_signaling 646..727 CDD:238492 14/91 (15%)
PDZ 782..852 CDD:214570 14/71 (20%)
PDZ_signaling 993..1084 CDD:238492 29/91 (32%)
PDZ_signaling 1210..1286 CDD:238492 26/81 (32%)
MPDZ_u10 1367..1424 CDD:318804 9/56 (16%)
PDZ_signaling 1427..1506 CDD:238492 16/99 (16%)
PDZ_signaling 1531..1612 CDD:238492 32/90 (36%)
PDZ_signaling 1649..1729 CDD:238492 20/89 (22%)
PDZ_signaling 1771..1853 CDD:238492 21/78 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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